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Ddc Gene Detail
Summary
  • Symbol
    Ddc
  • Name
    dopa decarboxylase
  • Synonyms
    Aadc, aromatic L-amino acid decarboxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:94876
    NCBI Gene: 13195
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:11764101-11848144 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 7.09 cM, cytoband A1-A4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2037 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94876
 protein coding gene Chr11:11764101-11848144 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018047
 protein coding gene Chr11:9110352-9197667 (-)
A/J MGP_AJ_G0018020
 protein coding gene Chr11:8789931-8878021 (-)
AKR/J MGP_AKRJ_G0017984
 protein coding gene Chr11:9158122-9246191 (-)
BALB/cJ MGP_BALBcJ_G0017988
 protein coding gene Chr11:8810280-8895119 (-)
C3H/HeJ MGP_C3HHeJ_G0017801
 protein coding gene Chr11:9059338-9149468 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018440
 protein coding gene Chr11:9419789-9515511 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016098
 protein coding gene Chr11:8333972-8417833 (-)
CAST/EiJ MGP_CASTEiJ_G0017363
 protein coding gene Chr11:9071914-9167447 (-)
CBA/J MGP_CBAJ_G0017776
 protein coding gene Chr11:10098069-10192014 (-)
DBA/2J MGP_DBA2J_G0017886
 protein coding gene Chr11:8723699-8807998 (-)
FVB/NJ MGP_FVBNJ_G0017878
 protein coding gene Chr11:8632976-8721314 (-)
LP/J MGP_LPJ_G0017957
 protein coding gene Chr11:9214438-9304590 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017904
 protein coding gene Chr11:9814620-9913469 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018481
 protein coding gene Chr11:9181047-9272096 (-)
PWK/PhJ MGP_PWKPhJ_G0017143
 protein coding gene Chr11:8759288-8848067 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016940
 protein coding gene Chr11:9027958-9113443 (-)
WSB/EiJ MGP_WSBEiJ_G0017417
 protein coding gene Chr11:8941985-9033213 (-)



Homology
more
  • Human Ortholog
    DDC, dopa decarboxylase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDC, dopa decarboxylase
  • Synonyms
    AADC
  • Links
    NCBI Gene ID: 1644
    neXtProt AC: NX_P20711
    UniProt: P20711

  • Chr Location
    7p12.2-p12.1; chr7:50458436-50565405 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ddc mouse models; 5 with human DDC associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypes from 5 alleles in 8 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele exhibit preweaning phenotype. Mice homozygous for a different knock-in allele exhibit partial prenatal lethality, decreased body size, postnatal growth retardation, hypoactivity, increased anxiety, tremors, decreased heart rate and decreased dopamine levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1004
  • Tissues
    159
  • cDNA Data
    55
  • Literature Summary
    61
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13195 NCBI Gene Model | MGI Sequence Detail 84044 C57BL/6J ±  kb
    transcript NM_001417459 RefSeq | MGI Sequence Detail 2066 ZRU/MplStud  
    polypeptide O88533 UniProt | EBI | MGI Sequence Detail 480 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000006342 aromatic-L-amino-acid decarboxylase
      (term hierarchy)
    • EC
      4.1.1.28
    • InterPro Domains
      IPR010977 Aromatic-L-amino-acid decarboxylase
      IPR021115 Pyridoxal-phosphate binding site
      IPR002129 Pyridoxal phosphate-dependent decarboxylase
      IPR015424 Pyridoxal phosphate-dependent transferase
      IPR015421 Pyridoxal phosphate-dependent transferase, major domain
      IPR015422 Pyridoxal phosphate-dependent transferase, small domain
    • GlyGen
      O88533 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 82
      cDNA 60
      Primer pair 16
      Other 6

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-8818
    References
    more
    • Summaries
      All 116
      Developmental Gene Expression 61
      Diseases 1
      Gene Ontology 12
      Phenotypes 24
    • Earliest
      J:1591 Bruneau G, et al., Mapping of the dopa decarboxylase gene to the 11A band of the murine genome. Biochem Biophys Res Commun. 1992 Jul 31;186(2):926-30
    • Latest
      J:358342 Mo C, et al., Dopaminylation of endothelial TPI1 suppresses ferroptotic angiocrine signals to promote lung regeneration over fibrosis. Cell Metab. 2024 Aug 6;36(8):1839-1857.e12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory