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Dlk1 Gene Detail
Summary
  • Symbol
    Dlk1
  • Name
    delta like non-canonical Notch ligand 1
  • Synonyms
    DlkI, FA1, Peg9, pG2, pref-1, SCP1, ZOG
  • Feature Type
    protein coding gene
  • IDs
    MGI:94900
    NCBI Gene: 13386
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:109418749-109429262 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 60.17 cM, cytoband E-F1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    58 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94900
 protein coding gene Chr12:109418411-109429262 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020114
 protein coding gene Chr12:111666572-111677079 (+)
A/J MGP_AJ_G0020068
 protein coding gene Chr12:107373853-107384368 (+)
AKR/J MGP_AKRJ_G0020044
 protein coding gene Chr12:110504202-110514707 (+)
BALB/cJ MGP_BALBcJ_G0020054
 protein coding gene Chr12:107827587-107838095 (+)
C3H/HeJ MGP_C3HHeJ_G0019856
 protein coding gene Chr12:110938818-110950515 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020499
 protein coding gene Chr12:115078997-115089655 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018111
 protein coding gene Chr12:103901400-103912042 (+)
CAST/EiJ MGP_CASTEiJ_G0019398
 protein coding gene Chr12:105894736-105906575 (+)
CBA/J MGP_CBAJ_G0019823
 protein coding gene Chr12:119633510-119644022 (+)
DBA/2J MGP_DBA2J_G0019940
 protein coding gene Chr12:106929683-106940493 (+)
FVB/NJ MGP_FVBNJ_G0019925
 protein coding gene Chr12:105716818-105727322 (+)
LP/J MGP_LPJ_G0020015
 protein coding gene Chr12:111500069-111511314 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019963
 protein coding gene Chr12:122777640-122789978 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020528
 protein coding gene Chr12:109983454-109993967 (+)
PWK/PhJ MGP_PWKPhJ_G0019157
 protein coding gene Chr12:101532867-101543541 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018961
 protein coding gene Chr12:104159622-104170165 (+)
WSB/EiJ MGP_WSBEiJ_G0019455
 protein coding gene Chr12:110901304-110911807 (+)



Homology
more
  • Human Ortholog
    DLK1, delta like non-canonical Notch ligand 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLK1, delta like non-canonical Notch ligand 1
  • Synonyms
    Delta1, DLK, DLK-1, FA1, pG2, Pref-1, PREF1, ZOG
  • Links
    NCBI Gene ID: 8788
    neXtProt AC: NX_P80370
    UniProt: P80370

  • Chr Location
    14q32.2; chr14:100725705-100738224 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 5 alleles in 8 genetic backgrounds
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygote null mice have reduced fetal growth and 50% lethality 2 days after birth. Survivors are small but have enlarged fat pad masses. Homozygotes for another null allele have abnormal B cell development. Paternally-inherited null alleles phenocopy homozygotes due to maternal imprinting.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1480
  • Tissues
    333
  • cDNA Data
    32
  • Literature Summary
    152
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000040856 Ensembl Gene Model | MGI Sequence Detail 10514 C57BL/6J ±  kb
    transcript ENSMUST00000056110 Ensembl | MGI Sequence Detail 4653 Not Applicable  
    polypeptide ENSMUSP00000063104 Ensembl | MGI Sequence Detail 385 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      13 Sequences
    • Protein Ontology
      PR:000006521 protein delta homolog 1
      (term hierarchy)
    • InterPro Domains
      IPR001881 EGF-like calcium-binding domain
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR052485 MEGF-related differentiation regulators
    • GlyGen
      Q09163 11 sites, 19 N-linked glycans (3 sites), 6 O-linked glycans (7 sites)
    Molecular
    Reagents
    less
    • All nucleic 92
      Genomic 5
      cDNA 34
      Primer pair 45
      Other 8

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-8856, MGI:2145055
    References
    more
    • Summaries
      All 276
      Developmental Gene Expression 152
      Gene Ontology 14
      Phenotypes 44
    • Earliest
      J:3994 Laborda J, et al., dlk, a putative mammalian homeotic gene differentially expressed in small cell lung carcinoma and neuroendocrine tumor cell line. J Biol Chem. 1993 Feb 25;268(6):3817-20
    • Latest
      J:353308 Teng X, et al., LncRNAs in the Dlk1-Dio3 Domain Are Essential for Mid-Embryonic Heart Development. Int J Mol Sci. 2024 Jul 26;25(15)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory