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Dlx1 Gene Detail
Summary
  • Symbol
    Dlx1
  • Name
    distal-less homeobox 1
  • Synonyms
    DII B, Dlx, Dlx-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94901
    NCBI Gene: 13390
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr2:71358457-71364325 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 42.61 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94901
 protein coding gene Chr2:71358457-71364325 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025824
 protein coding gene Chr2:71646383-71652251 (+)
A/J MGP_AJ_G0025802
 protein coding gene Chr2:68841312-68847182 (+)
AKR/J MGP_AKRJ_G0025770
 protein coding gene Chr2:70731531-70737401 (+)
BALB/cJ MGP_BALBcJ_G0025796
 protein coding gene Chr2:69029877-69035745 (+)
C3H/HeJ MGP_C3HHeJ_G0025556
 protein coding gene Chr2:70938330-70944192 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026243
 protein coding gene Chr2:73807044-73812912 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023646
 protein coding gene Chr2:66065371-66071258 (+)
CAST/EiJ MGP_CASTEiJ_G0025020
 protein coding gene Chr2:71127095-71132993 (+)
CBA/J MGP_CBAJ_G0025537
 protein coding gene Chr2:76526107-76531975 (+)
DBA/2J MGP_DBA2J_G0025668
 protein coding gene Chr2:68480274-68486144 (+)
FVB/NJ MGP_FVBNJ_G0025630
 protein coding gene Chr2:67869429-67875299 (+)
LP/J MGP_LPJ_G0025756
 protein coding gene Chr2:71505770-71511638 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025661
 protein coding gene Chr2:78513047-78518917 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026300
 protein coding gene Chr2:70835480-70841348 (+)
PWK/PhJ MGP_PWKPhJ_G0024761
 protein coding gene Chr2:68351960-68357851 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024569
 protein coding gene Chr2:71023242-71029116 (+)
WSB/EiJ MGP_WSBEiJ_G0025088
 protein coding gene Chr2:71268834-71274702 (+)



Homology
more
  • Human Ortholog
    DLX1, distal-less homeobox 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLX1, distal-less homeobox 1
  • Links
    NCBI Gene ID: 1745
    neXtProt AC: NX_P56177
    UniProt: P56177

  • Chr Location
    2q31.1; chr2:172084740-172089677 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 2 genetic backgrounds
    13 phenotypes from multigenic genotypes
    76 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants show morphogenetic abnormalities in first and second branchial arch-derived proximal skeletal and soft tissue structures; in double mutants with a Dlx2 null allele, maxillary molar teeth are missing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    59
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1884
  • Tissues
    445
  • cDNA Data
    28
  • Literature Summary
    206
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13390 NCBI Gene Model | MGI Sequence Detail 5869 C57BL/6J ±  kb
    transcript NM_001416985 RefSeq | MGI Sequence Detail 2907 ZRU/MplStud  
    polypeptide Q64317 UniProt | EBI | MGI Sequence Detail 255 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 6
      cDNA 33
      Primer pair 9
      Other 17

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-8857, MGD-MRK-8861
    References
    more
    • Summaries
      All 301
      Developmental Gene Expression 206
      Gene Ontology 18
      Phenotypes 76
    • Earliest
      J:11292 Price M, et al., A mouse gene related to Distal-less shows a restricted expression in the developing forebrain. Nature. 1991 Jun 27;351(6329):748-51
    • Latest
      J:358818 Chen L, et al., Hyperactive mTORC1 in striatum dysregulates dopamine receptor expression and odor preference behavior. Front Neurosci. 2024;18:1461178
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory