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Dlx2 Gene Detail
Summary
  • Symbol
    Dlx2
  • Name
    distal-less homeobox 2
  • Synonyms
    DII A, Dlx-2, Tes-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94902
    NCBI Gene: 13392
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:71373752-71377095 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 42.65 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    104 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94902
 protein coding gene Chr2:71373752-71377098 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025825
 protein coding gene Chr2:71662760-71666106 (-)
A/J MGP_AJ_G0025803
 protein coding gene Chr2:68857087-68860432 (-)
AKR/J MGP_AKRJ_G0025771
 protein coding gene Chr2:70746800-70750145 (-)
BALB/cJ MGP_BALBcJ_G0025797
 protein coding gene Chr2:69045968-69049314 (-)
C3H/HeJ MGP_C3HHeJ_G0025557
 protein coding gene Chr2:70953598-70956943 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026244
 protein coding gene Chr2:73822234-73825580 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023647
 protein coding gene Chr2:66080707-66084038 (-)
CAST/EiJ MGP_CASTEiJ_G0025021
 protein coding gene Chr2:71146508-71149859 (-)
CBA/J MGP_CBAJ_G0025538
 protein coding gene Chr2:76546621-76549967 (-)
DBA/2J MGP_DBA2J_G0025669
 protein coding gene Chr2:68495468-68498814 (-)
FVB/NJ MGP_FVBNJ_G0025631
 protein coding gene Chr2:67885350-67888695 (-)
LP/J MGP_LPJ_G0025757
 protein coding gene Chr2:71522497-71525843 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025662
 protein coding gene Chr2:78528443-78531788 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026301
 protein coding gene Chr2:70851683-70855029 (-)
PWK/PhJ MGP_PWKPhJ_G0024762
 protein coding gene Chr2:68367625-68371058 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024570
 protein coding gene Chr2:71038526-71041874 (-)
WSB/EiJ MGP_WSBEiJ_G0025089
 protein coding gene Chr2:71286030-71289376 (-)



Homology
more
  • Human Ortholog
    DLX2, distal-less homeobox 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLX2, distal-less homeobox 2
  • Synonyms
    TES-1, TES1
  • Links
    NCBI Gene ID: 1746
    neXtProt AC: NX_Q07687
    UniProt: Q07687

  • Chr Location
    2q31.1; chr2:172099438-172102900 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants show morphogenetic abnormalities in first and second branchial arch-derived proximal skeletal and soft tissue structures; in double mutants with a Dlx1 null allele, maxillary molar teeth are missing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2134
  • Tissues
    611
  • cDNA Data
    45
  • Literature Summary
    355
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13392 NCBI Gene Model | MGI Sequence Detail 3344 C57BL/6J ±  kb
    transcript NM_010054 RefSeq | MGI Sequence Detail 2470 ZRU/MplStud  
    polypeptide P40764 UniProt | EBI | MGI Sequence Detail 332 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 111
      Genomic 2
      cDNA 53
      Primer pair 14
      Other 42

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-8858, MGD-MRK-8862, MGI:2139313
    References
    more
    • Summaries
      All 434
      Developmental Gene Expression 355
      Gene Ontology 18
      Phenotypes 70
    • Earliest
      J:639 Robinson GW, et al., Spatially restricted expression of a member of a new family of murine Distal-less homeobox genes in the developing forebrain. New Biol. 1991 Dec;3(12):1183-94
    • Latest
      J:343718 Sun J, et al., Effects of Dlx2 overexpression on the genes associated with the maxillary process in the early mouse embryo. Front Genet. 2023;14:1085263
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory