Dmc Gene Detail

Summary

• Symbol
  Dmc
• Name
  DMCM susceptibility

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:94908
  NCBI Gene: 104147
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome Unknown

Mutations,
Alleles, and
Phenotypes

Using methyl 6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM), an inverse agonist of benzodiazepine, SWR was found to be less susceptible than CBA to DMCM induced seizures. The difference segregated as an autosomal gene, Dmc, distinct from the locus for caffeine susceptibility (see Caf).

Sequences &
Gene Models

• NCBI Gene
  104147

Other
Accession IDs

MGD-MRK-8868

References

• Summaries
  All 2
• Earliest
  J:8861 Seale TW, et al., Different genes specify hyporesponsiveness to seizures induced by caffeine and the benzodiazepine inverse agonist, DMCM. Pharmacol Biochem Behav. 1987 Jul;27(3):451-6