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Dsg1a Gene Detail
Summary
  • Symbol
    Dsg1a
  • Name
    desmoglein 1 alpha
  • Synonyms
    Dsg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94930
    NCBI Gene: 13510
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:20443982-20476407 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 11.29 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    892 from dbSNP Build 142
  • Strain Annotations
    7
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94930
 protein coding gene Chr18:20443868-20476407 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J MGP_AKRJ_G0024109
 protein coding gene Chr18:17919283-17979069 (+)
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0024584
 protein coding gene Chr18:18622107-18759491 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022025
 protein coding gene Chr18:16458362-16497398 (+)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0023975
 protein coding gene Chr18:16989117-17025683 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0024002
 protein coding gene Chr18:19969880-20085635 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024631
 protein coding gene Chr18:17649848-17702214 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    DSG1, desmoglein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DSG1, desmoglein 1
  • Synonyms
    CDHF4, DG1, DSG, EPKHE, EPKHIA, PPKS1, SPPK1
  • Links
    NCBI Gene ID: 1828
    neXtProt AC: NX_Q02413
    UniProt: Q02413

  • Chr Location
    18q12.1; chr18:31318160-31359246 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DSG1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    72
  • cDNA Data
    14
  • Literature Summary
    31
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13510 NCBI Gene Model | MGI Sequence Detail 32426 C57BL/6J ±  kb
transcript NM_010079 RefSeq | MGI Sequence Detail 5572 C57BL/6  
polypeptide Q61495 UniProt | EBI | MGI Sequence Detail 1057 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 15
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-8905, MGI:2147383
References
more
  • Summaries
    All 80
    Developmental Gene Expression 31
    Gene Ontology 11
    Phenotypes 6
  • Earliest
    J:4712 Buxton RS, et al., Nomenclature of the desmosomal cadherins. J Cell Biol. 1993 May;121(3):481-3
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory