Dvl1 MGI Mouse Gene Detail - MGI:94941 - dishevelled segment polarity protein 1

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Dvl1 Gene Detail

Symbol

Dvl1
Name

dishevelled segment polarity protein 1

Feature Type

protein coding gene
IDs

MGI:94941
NCBI Gene: 13542
Alliance

gene page
Transcription Start Sites

2 TSS
Candidate for QTL

5 QTL

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Sequence Map

Chr4:155931859-155943760 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 87.61 cM
Mapping Data

17 experiments

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SNPs within 2kb

490 from dbSNP Build 142
Strain Annotations

18
PCR

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_94941	protein coding gene	Chr4:155931829-155943760 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029233	protein coding gene	Chr4:160217062-160229791 (+)
A/J	MGP_AJ_G0029198	protein coding gene	Chr4:153465418-153477667 (+)
AKR/J	MGP_AKRJ_G0029146	protein coding gene	Chr4:157644521-157656436 (+)
BALB/cJ	MGP_BALBcJ_G0029214	protein coding gene	Chr4:153939446-153951359 (+)
C3H/HeJ	MGP_C3HHeJ_G0028935	protein coding gene	Chr4:158187052-158199069 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029663	protein coding gene	Chr4:165894804-165906705 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026908	protein coding gene	Chr4:145753862-145765891 (+)
CAST/EiJ	MGP_CASTEiJ_G0028347	protein coding gene	Chr4:155658599-155670691 (+)
CBA/J	MGP_CBAJ_G0028897	protein coding gene	Chr4:170909637-170921550 (+)
DBA/2J	MGP_DBA2J_G0029046	protein coding gene	Chr4:153486601-153498514 (+)
FVB/NJ	MGP_FVBNJ_G0029009	protein coding gene	Chr4:152735925-152747839 (+)
LP/J	MGP_LPJ_G0029136	protein coding gene	Chr4:160145326-160157238 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029036	protein coding gene	Chr4:173723342-173735256 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029695	protein coding gene	Chr4:158270580-158282492 (+)
PWK/PhJ	MGP_PWKPhJ_G0028068	protein coding gene	Chr4:149630062-149642224 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027902	protein coding gene	Chr4:152529323-152541246 (+)
WSB/EiJ	MGP_WSBEiJ_G0028427	protein coding gene	Chr4:158444593-158456508 (+)

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Human Ortholog

DVL1, dishevelled segment polarity protein 1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DVL1, dishevelled segment polarity protein 1
Synonyms

DRS2, DVL, DVL1L1, DVL1P1
Links

HGNC:3084

NCBI Gene ID: 1855

neXtProt AC: NX_O14640

UniProt: O14640
Chr Location

1p36.33; chr1:1335276-1349418 (-) GRCh38

Human Ortholog

DVL1P1, dishevelled segment polarity protein 1 pseudogene 1
Synonyms

DSH, DVL, DVL1, DVL1L1, DVL-22, DVL4
Links

HGNC:3085

NCBI Gene ID: 8215
Chr Location

22q11.21,22q11; chr22:19253131-19253469 (-) GRCh38

MGI Vertebrate Homology

Dvl1 stringent orthology
2 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DVL1, DVL1P1
Gene Tree

Dvl1

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Diseases

2 with human DVL1,DVL1P1 associations

				Human Disease	Mouse Models
				autosomal dominant Robinow syndrome 2 IDs autosomal dominant Robinow syndrome 2 DOID:0060765 OMIM:616331 ORDO:3107
				DiGeorge syndrome IDs DiGeorge syndrome DOID:11198 ICD10CM:D82.1 ICD9CM:279.11 MESH:D004062 NCI:C2989 OMIM:188400 UMLS_CUI:C0012236

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
25 phenotypes from multigenic genotypes
26 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available

Homozygous targeted mutants are viable and fertile, but show a number of behavioral changes including deficient nest-building, less huddling contact during sleep, reduced subordinate responses, and other social interaction deficits.

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All GO Annotations

139
GO References

48

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1045
Tissues

189
cDNA Data

81
Literature Summary

36

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA DVL1

Xenbase dvl1

ZFIN dvl1b

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All Sequences

64
RefSeq

16
UniProt

3
CCDS

CCDS19045.1

Ensembl

ENSMUSG00000029071 (Evidence)
NCBI Gene

13542

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000029071	Ensembl Gene Model \| MGI Sequence Detail	11902	C57BL/6J	± kb
	transcript	ENSMUST00000030948	Ensembl \| MGI Sequence Detail	3358	Not Applicable
	polypeptide	ENSMUSP00000030948	Ensembl \| MGI Sequence Detail	695	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006765 segment polarity protein dishevelled homolog DVL-1

(term hierarchy)
PDB

1FSH, 1MC7, 2KAW, 2MX6, 3PZ8
InterPro Domains

IPR000591 DEP domain

IPR024580 Dishevelled C-terminal

IPR008339 Dishevelled family

IPR003351 Dishevelled protein domain

IPR015506 Dishevelled-related protein

IPR001158 DIX domain

IPR038207 DIX domain superfamily

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR029071 Ubiquitin-like domain superfamily

IPR036390 Winged helix DNA-binding domain superfamily

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

P51141 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 94

Genomic 3

cDNA 82

Primer pair 9

Microarray probesets 3

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MGD-MRK-8919

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Summaries

All 144

Developmental Gene Expression 36

Gene Ontology 48

Phenotypes 26
Earliest

J:2643 Beier DR, et al., Mapping genes in the mouse using single-strand conformation polymorphism analysis of recombinant inbred strains and interspecific crosses. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9102-6
Latest

J:355261 Rehmani T, et al., SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP. Life Sci Alliance. 2024 Dec;7(12)

TSS for Dvl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40735	Chr4:155931850-155931924 (+)	28 bp
Tssr40736	Chr4:155931956-155931973 (+)	106 bp

Dvl1 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bglq4	Chr4, 33.96 cM		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.
Dob1	Chr4, syntenic	Chr4:101574601-123127211	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.
Nidd1	Chr4, syntenic		J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.
Tafat	Chr4, 74.75 cM	Chr4:141621281-141621387	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.
Triglq1	Chr4, 10.61 cM	Chr4:25683240-25683429	J:99477	Authors used novel data mining tool ExQuest to identify novel candidate genes for existing diabesity QTLs. Next, candidate gene expression in the liver, adipose, and pancreas of diabesity-prone Tally Ho mice and diabesity-resistant C57BL/6J mice was assessed by quantitative PCR analysis. Several potential candidate genes, some with no previous association to diabesity QTLs, were identified. Since QTL intervals may be large and could contain hundreds or thousands of potential candidate genes, this method allows researchers to focus on those with strong potential as well as identify novel candidate genes. Potential candidate genes for Tafat (80 cM) on mouse Chromosome 4 as identified by ExQuest are Ela2, Ela3b, and Dvl1 (82 cM). Chr 10 locus Ela2 exhibits 55-fold decreased expression in the pancreas of Tally Ho animals compared to C57BL/6J. For QTL Bwq1 (6.3 cM), potential candidate gene Decr1 was identified. For QTLs Triglq1 (6.5 cM) and Bglq4 (6.5 cM), potential candidate genes Ttpa, Bhmt(Chr 13), Baat(22.7 cM), and Aldob (22.3 cM) were identified. For QTLs Nidd1 (48 cM) and Dob1 (50 cM), potential candidate genes Lepr (46.7 cM), Dio1 (48.7 cM), Scp2 (52 cM), Faah (56.5 cM), and Usp1 were identified.

*cM position of peak correlated region/marker

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