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Epha7 Gene Detail
Summary
  • Symbol
    Epha7
  • Name
    Eph receptor A7
  • Synonyms
    Cek11, Ebk, Ehk3, Hek11, Mdk1, MDK1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95276
    NCBI Gene: 13841
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:28813131-28967499 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 12.42 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4456 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95276
 protein coding gene Chr4:28811840-28969391 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028107
 protein coding gene Chr4:26101051-26264302 (+)
A/J MGP_AJ_G0028065
 protein coding gene Chr4:25283528-25438534 (+)
AKR/J MGP_AKRJ_G0028029
 protein coding gene Chr4:25856779-26016434 (+)
BALB/cJ MGP_BALBcJ_G0028075
 protein coding gene Chr4:25415767-25572080 (+)
C3H/HeJ MGP_C3HHeJ_G0027806
 protein coding gene Chr4:26078031-26236319 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028518
 protein coding gene Chr4:27176082-27341726 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025860
 protein coding gene Chr4:23419087-23571440 (+)
CAST/EiJ MGP_CASTEiJ_G0027260
 protein coding gene Chr4:25804933-26044791 (+)
CBA/J MGP_CBAJ_G0027778
 protein coding gene Chr4:28015982-28201085 (+)
DBA/2J MGP_DBA2J_G0027922
 protein coding gene Chr4:25224166-25380124 (+)
FVB/NJ MGP_FVBNJ_G0027887
 protein coding gene Chr4:24734495-24890857 (+)
LP/J MGP_LPJ_G0028030
 protein coding gene Chr4:26244080-26405312 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027920
 protein coding gene Chr4:30296755-30482536 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028577
 protein coding gene Chr4:25854906-26014568 (+)
PWK/PhJ MGP_PWKPhJ_G0026980
 protein coding gene Chr4:25099696-25264036 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026808
 protein coding gene Chr4:25638520-25807597 (+)
WSB/EiJ MGP_WSBEiJ_G0027337
 protein coding gene Chr4:25880227-26043092 (+)



Homology
more
  • Human Ortholog
    EPHA7, EPH receptor A7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPHA7, EPH receptor A7
  • Synonyms
    EHK-3, EHK3, EK11, HEK11
  • Links
    NCBI Gene ID: 2045
    neXtProt AC: NX_Q15375
    UniProt: Q15375

  • Chr Location
    6q16.1; chr6:93240020-93419687 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Some homozygous mutants display anencephaly. Mutants also exhibit increased proliferation of neural progenitor cells in the lateral ventricle wall of the adult brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    82
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1724
  • Tissues
    508
  • cDNA Data
    87
  • Literature Summary
    97
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028289 Ensembl Gene Model | MGI Sequence Detail 154369 C57BL/6J ±  kb
    transcript ENSMUST00000029964 Ensembl | MGI Sequence Detail 6746 Not Applicable  
    polypeptide ENSMUSP00000029964 Ensembl | MGI Sequence Detail 998 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000007127 ephrin type-A receptor 7
      (term hierarchy)
    • EC
      2.7.10.1
    • InterPro Domains
      IPR001090 Ephrin receptor ligand binding domain
      IPR027936 Ephrin receptor, transmembrane domain
      IPR016257 Ephrin receptor type-A /type-B
      IPR050449 Ephrin receptor tyrosine kinases
      IPR034283 Ephrin type-A receptor 7, ligand binding domain
      IPR003961 Fibronectin type III
      IPR036116 Fibronectin type III superfamily
      IPR008979 Galactose-binding-like domain superfamily
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR001660 Sterile alpha motif domain
      IPR013761 Sterile alpha motif/pointed domain superfamily
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
    • GlyGen
      Q61772 3 sites, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 115
      cDNA 89
      Primer pair 13
      Other 13

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-9291
    References
    more
    • Summaries
      All 151
      Developmental Gene Expression 97
      Gene Ontology 16
      Phenotypes 18
    • Earliest
      J:22410 Ciossek T, et al., Identification of alternatively spliced mRNAs encoding variants of MDK1, a novel receptor tyrosine kinase expressed in the murine nervous system. Oncogene. 1995 Jan 5;10(1):97-108
    • Latest
      J:347974 Zhou B, et al., Identification of signaling pathways that specify a subset of migrating enteric neural crest cells at the wavefront in mouse embryos. Dev Cell. 2024 Apr 15;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory