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Eif1a Gene Detail
Summary
  • Symbol
    Eif1a
  • Name
    eukaryotic translation initiation factor 1A
  • Synonyms
    Ef1a, Eftu, eIF-1A, Eif4c
  • Feature Type
    protein coding gene
  • IDs
    MGI:95298
    NCBI Gene: 13664
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:46730771-46743292 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 24.68 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    368 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95298
 protein coding gene Chr18:46730768-46749523 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024410
 protein coding gene Chr18:45407257-45423675 (+)
A/J MGP_AJ_G0024377
 protein coding gene Chr18:43778912-43793273 (+)
AKR/J MGP_AKRJ_G0024346
 protein coding gene Chr18:44975076-44990136 (+)
BALB/cJ MGP_BALBcJ_G0024377
 protein coding gene Chr18:43877317-43890897 (+)
C3H/HeJ MGP_C3HHeJ_G0024144
 protein coding gene Chr18:45063662-45077226 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024821
 protein coding gene Chr18:47011889-47025943 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022256
 protein coding gene Chr18:43594839-43607288 (+)
CAST/EiJ MGP_CASTEiJ_G0023618
 protein coding gene Chr18:45013561-45032011 (+)
CBA/J MGP_CBAJ_G0024113
 protein coding gene Chr18:48281538-48294124 (+)
DBA/2J MGP_DBA2J_G0024243
 protein coding gene Chr18:43385252-43398659 (+)
FVB/NJ MGP_FVBNJ_G0024209
 protein coding gene Chr18:42952288-42964679 (+)
LP/J MGP_LPJ_G0024327
 protein coding gene Chr18:45480721-45494269 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024240
 protein coding gene Chr18:49628693-49653912 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024868
 protein coding gene Chr18:44895975-44910747 (+)
PWK/PhJ MGP_PWKPhJ_G0023362
 protein coding gene Chr18:43528827-43543021 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014754
 protein coding gene Chr1:9646838-9649764 (+)
WSB/EiJ MGP_WSBEiJ_G0023681
 protein coding gene Chr18:44790713-44806416 (+)



Homology
more
  • Human Ortholog
    EIF1AX, eukaryotic translation initiation factor 1A X-linked
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF1AX, eukaryotic translation initiation factor 1A X-linked
  • Synonyms
    eIF-1A, EIF1A, EIF1AP1, eIF-4C, EIF4C
  • Links
    NCBI Gene ID: 1964
    neXtProt AC: NX_P47813
    UniProt: P47813

  • Chr Location
    Xp22.12; chrX:20124525-20141838 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Female mice homozygous for a conditional ready, reporter allele are not viable, whereas males are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    22
  • cDNA Data
    21
  • Literature Summary
    19
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13664 NCBI Gene Model | MGI Sequence Detail 12522 C57BL/6J ±  kb
transcript NM_001374654 RefSeq | MGI Sequence Detail 3201 C57BL/6  
polypeptide Q60872 UniProt | EBI | MGI Sequence Detail 144 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000007286 eukaryotic translation initiation factor 1A
    (term hierarchy)
  • InterPro Domains
    IPR012340 Nucleic acid-binding, OB-fold
    IPR006196 RNA-binding domain, S1, IF1 type
    IPR001253 Translation initiation factor 1A (eIF-1A)
    IPR018104 Translation initiation factor 1A (eIF-1A), conserved site
Molecular
Reagents
less
  • All nucleic 34
    cDNA 22
    Primer pair 11
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-33875, MGD-MRK-9310, MGD-MRK-9313, MGD-MRK-9330, MGI:2147394
References
more
  • Summaries
    All 64
    Developmental Gene Expression 19
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:9029 Roth WW, et al., Expression of a gene for mouse eucaryotic elongation factor Tu during murine erythroleukemic cell differentiation. Mol Cell Biol. 1987 Nov;7(11):3929-36
  • Latest
    J:349160 Lamacova L, et al., CPEB3 Maintains Developmental Competence of the Oocyte. Cells. 2024 May 16;13(10)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory