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Erbb2 Gene Detail
Summary
  • Symbol
    Erbb2
  • Name
    erb-b2 receptor tyrosine kinase 2
  • Synonyms
    c-erbB2, c-neu, ErbB-2, HER-2, HER2, l11Jus8, mKIAA3023, Neu, Neu oncogene
  • Feature Type
    protein coding gene
  • IDs
    MGI:95410
    NCBI Gene: 13866
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98303310-98328542 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 61.75 cM, cytoband D
  • Mapping Data
    27 experiments
Strain
Comparison
more
  • SNPs within 2kb
    635 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95410
 protein coding gene Chr11:98303296-98328542 (+)
129S1/SvImJ ENSMUSG00200047770
 protein coding gene Chr11:95558349-95583551 (+)
A/J ENSMUSG00195052092
 protein coding gene Chr11:95273400-95298639 (+)
AKR/J ENSMUSG00220049908
 protein coding gene Chr11:95532511-95557772 (+)
BALB/cJ ENSMUSG00180049608
 protein coding gene Chr11:95545181-95570442 (+)
C3H/HeJ ENSMUSG00175049493
 protein coding gene Chr11:95531959-95557146 (+)
C57BL/6NJ ENSMUSG00215052877
 protein coding gene Chr11:95121469-95146713 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017084
 protein coding gene Chr11:94198025-94223180 (+)
CAST/EiJ ENSTCUG00005045529
 protein coding gene Chr11:94984300-95009656 (+)
CBA/J ENSMUSG00210052999
 protein coding gene Chr11:95235425-95260662 (+)
DBA/2J ENSMUSG00185050537
 protein coding gene Chr11:95581865-95607062 (+)
FVB/NJ ENSMUSG00205048003
 protein coding gene Chr11:95448769-95473974 (+)
JF1/MsJ ENSUMUG00000054352
 protein coding gene Chr11:95887654-95913010 (+)
LP/J ENSMUSG00230046284
 protein coding gene Chr11:96634767-96659967 (+)
NOD/ShiLtJ ENSMUSG00190040400
 protein coding gene Chr11:95623131-95648373 (+)
NZO/HlLtJ ENSMUSG00225051663
 protein coding gene Chr11:98686768-98712953 (+)
PWK/PhJ ENSLUMG00010050709
 protein coding gene Chr11:95439274-95464470 (+)
SPRET/EiJ ENSMSPG00010049888
 protein coding gene Chr11:95931964-95957128 (+)
WSB/EiJ ENSIUOG00005050310
 protein coding gene Chr11:95388398-95413651 (+)



Homology
more
  • Human Ortholog
    ERBB2, erb-b2 receptor tyrosine kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERBB2, erb-b2 receptor tyrosine kinase 2
  • Synonyms
    CD340, c-ERB-2, c-ERB2, HER-2, HER2, HER-2/neu, MLN 19, MLN-19, NEU, NGL, p185(erbB2), TKR1, VSCN2
  • Links
    NCBI Gene ID: 2064
    UniProt: P04626

  • Chr Location
    17q12; chr17:39687914-39730426 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Erbb2 mouse models; 9 with human ERBB2 associations

Human Disease Mouse Models
      
IDs
 View 4 models
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    88 phenotypes from 13 alleles in 15 genetic backgrounds
    46 phenotypes from multigenic genotypes
    128 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit degeneration of motor nerves, an absence of Schwann cells, impairment of junctional folds at the neuromuscular synapse, and cardiac defects that results in lethality by embryonic day 10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    207
  • GO References
    50
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1229
  • Tissues
    254
  • cDNA Data
    89
  • Literature Summary
    93
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13866 NCBI Gene Model | MGI Sequence Detail 25233 C57BL/6J ±  kb
    transcript NM_001003817 RefSeq | MGI Sequence Detail 4998 ZRU/MplStud  
    polypeptide P70424 UniProt | EBI | MGI Sequence Detail 1256 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000002082 receptor tyrosine-protein kinase erbB-2
      (term hierarchy)
    • EC
      2.7.10.1
    • InterPro Domains
      IPR051648 Cell Wall Integrity and Assembly Regulator
      IPR049328 Epidermal growth factor receptor-like, transmembrane-juxtamembrane segment
      IPR006211 Furin-like cysteine-rich domain
      IPR006212 Furin-like repeat
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
      IPR032778 Growth factor receptor domain 4
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR000494 Receptor L-domain
      IPR036941 Receptor L-domain superfamily
      IPR050122 Receptor Tyrosine Kinase
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR016245 Tyrosine protein kinase, EGF/ERB/XmrK receptor
    • GlyGen
      P70424 8 sites, 3 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 3
      cDNA 93
      Primer pair 9
      Other 5
      Antibodies 12

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9571, MGD-MRK-9573, MGI:2671273
    References
    more
    • Summaries
      All 565
      Developmental Gene Expression 93
      Diseases 5
      Gene Ontology 50
      Phenotypes 128
    • Earliest
      J:32779 Schechter AL, et al., The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen. Nature. 1984 Dec 6-12;312(5994):513-6
    • Latest
      J:388026 Zhao H, et al., HER2 deficiency causes a developmental disorder with growth retardation and craniofacial malformations. J Clin Invest. 2026 Jun 15;136(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory