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Erg Gene Detail
Summary
  • Symbol
    Erg
  • Name
    ETS transcription factor
  • Synonyms
    D030036I24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:95415
    NCBI Gene: 13876
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:95160028-95387452 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 56.04 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    841 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95415
 protein coding gene Chr16:95160028-95387452 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023076
 protein coding gene Chr16:96661954-96907409 (-)
A/J MGP_AJ_G0023044
 protein coding gene Chr16:92092847-92320905 (-)
AKR/J MGP_AKRJ_G0023014
 protein coding gene Chr16:94938629-95159924 (-)
BALB/cJ MGP_BALBcJ_G0023046
 protein coding gene Chr16:92639018-92866007 (-)
C3H/HeJ MGP_C3HHeJ_G0022807
 protein coding gene Chr16:95446969-95682051 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023493
 protein coding gene Chr16:99716832-99960319 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020995
 protein coding gene Chr16:89960029-90180515 (-)
CAST/EiJ MGP_CASTEiJ_G0022326
 protein coding gene Chr16:96232805-96463376 (-)
CBA/J MGP_CBAJ_G0022776
 protein coding gene Chr16:103997172-104250944 (-)
DBA/2J MGP_DBA2J_G0022910
 protein coding gene Chr16:91986167-92210392 (-)
FVB/NJ MGP_FVBNJ_G0022884
 protein coding gene Chr16:91147093-91376139 (-)
LP/J MGP_LPJ_G0022980
 protein coding gene Chr16:96293909-96534918 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022905
 protein coding gene Chr16:108311259-108547776 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023511
 protein coding gene Chr16:95451310-95682871 (-)
PWK/PhJ MGP_PWKPhJ_G0022071
 protein coding gene Chr16:92265849-92490155 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021901
 protein coding gene Chr16:94983524-95220773 (-)
WSB/EiJ MGP_WSBEiJ_G0022377
 protein coding gene Chr16:95723238-95946596 (-)



Homology
more
  • Human Ortholog
    ERG, ETS transcription factor ERG
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ERG, ETS transcription factor ERG
  • Synonyms
    erg-3, LMPHM14, p55
  • Links
    NCBI Gene ID: 2078
    neXtProt AC: NX_P11308
    UniProt: P11308

  • Chr Location
    21q22.2; chr21:38367261-38661783 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Erg mouse models; 2 with human ERG associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 7 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    119 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced mutation or a knock-out of isoforms 5 - 7 die during organogenesis and exhibit embryonic growth retardation. Mice homozygous for a knock-out of isoforms 1 - 4 are viable and fertile with no overt abnnormalities. Homozygous knock-out mice develop pulmonary venoocclusive disease, with pancytopenia, pulmonary hemorrhage and hypertension, and heart right ventricle hypertrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1508
  • Tissues
    432
  • cDNA Data
    22
  • Literature Summary
    105
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13876 NCBI Gene Model | MGI Sequence Detail 227425 C57BL/6J ±  kb
    transcript NM_001302152 RefSeq | MGI Sequence Detail 3283 ZRU/MplStud  
    polypeptide P81270 UniProt | EBI | MGI Sequence Detail 486 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 2
      cDNA 22
      Primer pair 5
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9581, MGI:2444253
    References
    more
    • Summaries
      All 270
      Developmental Gene Expression 105
      Diseases 7
      Gene Ontology 9
      Phenotypes 119
    • Earliest
      J:16358 Reddy ES, et al., The erg gene: a human gene related to the ets oncogene. Proc Natl Acad Sci U S A. 1987 Sep;84(17):6131-5
    • Latest
      J:354184 Pineiro-Sabaris R, et al., Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve. Dis Model Mech. 2024 Sep 1;17(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory