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Ces1c Gene Detail
Summary
  • Symbol
    Ces1c
  • Name
    carboxylesterase 1C
  • Synonyms
    Ces-N, Ee-1, Es-1, Es1, Es-4, Es-N
  • Feature Type
    protein coding gene
  • IDs
    MGI:95420
    NCBI Gene: 13884
  • Member of
    Ces1 cluster
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:93825643-93857911 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 44.99 cM
  • Mapping Data
    114 experiments
Strain
Comparison
more
  • SNPs within 2kb
    983 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95420
 protein coding gene Chr8:93825643-93857911 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033942
 protein coding gene Chr8:94421185-94448463 (-)
A/J MGP_AJ_G0033925
 protein coding gene Chr8:90705483-90732103 (-)
AKR/J MGP_AKRJ_G0033851
 protein coding gene Chr8:93249065-93275053 (-)
BALB/cJ MGP_BALBcJ_G0033917
 protein coding gene Chr8:90857566-90900862 (-)
C3H/HeJ MGP_C3HHeJ_G0033627
 protein coding gene Chr8:93967131-93991613 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034438
 protein coding gene Chr8:97897064-97929332 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031379
 protein coding gene Chr8:84593993-84651522 (-)
CAST/EiJ MGP_CASTEiJ_G0032959
 protein coding gene Chr8:93496344-93562819 (-)
CBA/J MGP_CBAJ_G0033603
 protein coding gene Chr8:101167408-101194218 (-)
DBA/2J MGP_DBA2J_G0033757
 protein coding gene Chr8:90212192-90290702 (-)
FVB/NJ MGP_FVBNJ_G0033704
 protein coding gene Chr8:89184503-89209277 (-)
LP/J MGP_LPJ_G0033849
 protein coding gene Chr8:94551888-94575537 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033746
 protein coding gene Chr8:103462972-103526990 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034456
 protein coding gene Chr8:93414376-93438994 (-)
PWK/PhJ MGP_PWKPhJ_G0032661
 protein coding gene Chr8:89597781-89605703 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032498
 protein coding gene Chr8:92242012-92267105 (-)
WSB/EiJ MGP_WSBEiJ_G0033071
 protein coding gene Chr8:93829881-93867460 (-)



Homology
more
  • Human Ortholog
    CES1, carboxylesterase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CES1, carboxylesterase 1
  • Synonyms
    ACAT, CE-1, CEH, CES2, hCE-1, HMSE, HMSE1, PCE-1, REH, SES1, TGH
  • Links
    NCBI Gene ID: 1066
    neXtProt AC: NX_P23141
    UniProt: P23141

  • Chr Location
    16q12.2; chr16:55802851-55833337 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CES1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit protection against nerve agents such as chlorpyrifos and chlorpyrifos oxon but increased sensitivity to soman coumarin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    808
  • Tissues
    95
  • cDNA Data
    157
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13884 NCBI Gene Model | MGI Sequence Detail 32269 C57BL/6J ±  kb
    transcript NM_007954 RefSeq | MGI Sequence Detail 1850 ZRU/MplStud  
    polypeptide P23953 UniProt | EBI | MGI Sequence Detail 554 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 160
      cDNA 158
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9303, MGD-MRK-9588, MGD-MRK-9613, MGD-MRK-9620, MGD-MRK-9621
    References
    more
    • Summaries
      All 146
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:13081 POPP RA, et al., Inheritance of serum esterases having different electrophoretic patterns. J Hered. 1962 May-Jun;53:111-4
    • Latest
      J:347555 Feng Y, et al., Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability. Cell Rep. 2023 Nov 28;42(12):113503
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory