Esl1 QTL Detail

Summary

• Symbol
  Esl1
• Name
  early lymphoma of SL 1

• Feature Type
  QTL
• IDs
  MGI:95449
  NCBI Gene: 109902

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 17, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  1 experiment

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 2 alleles in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

SL/Kh is genetically predisposed to spontaneous development of pre-B lymphomas, while NFS/N is not. NFS/N also carries no endogenous ecotropic proviruses. F1 mice develop tumors like SL/Kh and backcrosses showed an allele at Esl1 from SL/Kh was essentialfor early onset pre-B lymphoma development.

Sequences &
Gene Models

• NCBI Gene
  109902

Other
Accession IDs

MGD-MRK-9652

References

• Summaries
  All 6

  Phenotypes 1
• Earliest
  J:16441 Yamada Y, et al., Genetic predisposition to pre-B lymphomas in SL/Kh strain mice. Cancer Res. 1994 Jan 15;54(2):403-7
• Latest
  J:196660 Yang T, et al., E-selectin ligand 1 regulates bone remodeling by limiting bioactive TGF-beta in the bone microenvironment. Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7336-41