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Evx1 Gene Detail
Summary
  • Symbol
    Evx1
  • Name
    even-skipped homeobox 1
  • Synonyms
    Evx-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95461
    NCBI Gene: 14028
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:52290483-52295363 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 25.44 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95461
 protein coding gene Chr6:52290483-52295374 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030751
 protein coding gene Chr6:51566831-51571711 (+)
A/J MGP_AJ_G0030720
 protein coding gene Chr6:49150674-49155554 (+)
AKR/J MGP_AKRJ_G0030647
 protein coding gene Chr6:50862947-50867827 (+)
BALB/cJ MGP_BALBcJ_G0030732
 protein coding gene Chr6:49513510-49518390 (+)
C3H/HeJ MGP_C3HHeJ_G0030445
 protein coding gene Chr6:50872965-50877845 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031187
 protein coding gene Chr6:52710002-52714882 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028393
 protein coding gene Chr6:46796755-46801627 (+)
CAST/EiJ MGP_CASTEiJ_G0029848
 protein coding gene Chr6:50688800-50693685 (+)
CBA/J MGP_CBAJ_G0030419
 protein coding gene Chr6:54915490-54920370 (+)
DBA/2J MGP_DBA2J_G0030569
 protein coding gene Chr6:49074610-49079490 (+)
FVB/NJ MGP_FVBNJ_G0030521
 protein coding gene Chr6:48685354-48690234 (+)
LP/J MGP_LPJ_G0030654
 protein coding gene Chr6:51534867-51539747 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030555
 protein coding gene Chr6:57529456-57534336 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031217
 protein coding gene Chr6:50801859-50806739 (+)
PWK/PhJ MGP_PWKPhJ_G0029561
 protein coding gene Chr6:48697178-48702056 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029395
 protein coding gene Chr6:50130819-50135697 (+)
WSB/EiJ MGP_WSBEiJ_G0029925
 protein coding gene Chr6:50807564-50812445 (+)



Homology
more
  • Human Ortholog
    EVX1, even-skipped homeobox 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EVX1, even-skipped homeobox 1
  • Synonyms
    EVX-1
  • Links
    NCBI Gene ID: 2128
    neXtProt AC: NX_P49640
    UniProt: P49640

  • Chr Location
    7p15.2; chr7:27242700-27250493 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a particular targeted mutation are embryonic lethal. Another heritable cre-generated allele exhibits defects of the interneurons of the ventral spinal cord, and rarely, a kinked tail.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1102
  • Tissues
    187
  • cDNA Data
    11
  • Literature Summary
    119
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005503 Ensembl Gene Model | MGI Sequence Detail 4881 C57BL/6J ±  kb
    transcript ENSMUST00000031787 Ensembl | MGI Sequence Detail 2877 Not Applicable  
    polypeptide ENSMUSP00000031787 Ensembl | MGI Sequence Detail 416 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 7
      cDNA 11
      Primer pair 2
      Other 13

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9674, MGD-MRK-9676
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 119
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:10529 Bastian H, et al., A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner [published erratum appears in EMBO J 1991 Dec;10(12):3978]. EMBO J. 1990 Jun;9(6):1839-52
    • Latest
      J:343072 Vermeiren S, et al., Prdm12 represses the expression of the visceral neuron determinants Phox2a/b in developing somatosensory ganglia. iScience. 2023 Dec 15;26(12):108364
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory