Fbln2 MGI Mouse Gene Detail - MGI:95488

Symbol

Fbln2
Name

fibulin 2
Synonyms

5730577E14Rik

Feature Type

protein coding gene
IDs

MGI:95488
NCBI Gene: 14115
Alliance

gene page
Transcription Start Sites

20 TSS

Sequence Map

Chr6:91189442-91249522 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 40.42 cM, cytoband D-E
Mapping Data

5 experiments

SNPs within 2kb

1730 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95488	protein coding gene	Chr6:91189437-91249522 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031044	protein coding gene	Chr6:92799754-92859705 (+)
A/J	MGP_AJ_G0031012	protein coding gene	Chr6:89262536-89322755 (+)
AKR/J	MGP_AKRJ_G0030944	protein coding gene	Chr6:91742252-91802287 (+)
BALB/cJ	MGP_BALBcJ_G0031024	protein coding gene	Chr6:89202856-89264964 (+)
C3H/HeJ	MGP_C3HHeJ_G0030684	protein coding gene	Chr6:92638258-92699417 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031483	protein coding gene	Chr6:95216197-95279832 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028651	protein coding gene	Chr6:87242116-87302007 (+)
CAST/EiJ	MGP_CASTEiJ_G0030131	protein coding gene	Chr6:91856446-91917966 (+)
CBA/J	MGP_CBAJ_G0030710	protein coding gene	Chr6:98750824-98810916 (+)
DBA/2J	MGP_DBA2J_G0030863	protein coding gene	Chr6:88446654-88506610 (+)
FVB/NJ	MGP_FVBNJ_G0030817	protein coding gene	Chr6:87653147-87714356 (+)
LP/J	MGP_LPJ_G0030943	protein coding gene	Chr6:92758707-92819035 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030851	protein coding gene	Chr6:102823852-102887081 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031510	protein coding gene	Chr6:91586217-91646256 (+)
PWK/PhJ	MGP_PWKPhJ_G0029847	protein coding gene	Chr6:87395333-87455826 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029676	protein coding gene	Chr6:90490129-90551259 (+)
WSB/EiJ	MGP_WSBEiJ_G0030215	protein coding gene	Chr6:92045946-92107220 (+)

Human Ortholog

FBLN2, fibulin 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBLN2, fibulin 2
Links

HGNC:3601

NCBI Gene ID: 2199

neXtProt AC: NX_P98095

UniProt: P98095
Chr Location

3p25.1; chr3:13549125-13638422 (+) GRCh38

MGI Vertebrate Homology

Fbln2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FBLN2
Gene Tree

Fbln2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
15 phenotype references

All Mutations and Alleles

6
Endonuclease-mediated

4
Spontaneous

1
Targeted

1
Genomic Mutations

1 involving Fbln2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

52 strains or lines available

Mice homozygous for a knock-out alle are viable, fertile and grossly normal with no apparent defects in elastic fiber formation in the aorta and skin.

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All GO Annotations

10
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1129
Tissues

120
cDNA Data

13
Literature Summary

24

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FBLN2

ZFIN fbln2

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All Sequences

62
RefSeq

10
UniProt

6
CCDS

CCDS39566.1, CCDS39567.1

Ensembl

ENSMUSG00000064080 (Evidence)
NCBI Gene

14115

			Length	Strain/Species	Flank
genomic	14115	NCBI Gene Model \| MGI Sequence Detail	60081	C57BL/6J	± kb
transcript	NM_007992	RefSeq \| MGI Sequence Detail	4414	C57BL/6
polypeptide	P37889	UniProt \| EBI \| MGI Sequence Detail	1221	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007359 fibulin-2

(term hierarchy)
PDB

8R5W
InterPro Domains

IPR000020 Anaphylatoxin/fibulin

IPR026823 Complement Clr-like EGF domain

IPR018097 EGF-like calcium-binding, conserved site

IPR001881 EGF-like calcium-binding domain

IPR000742 EGF-like domain

IPR000152 EGF-type aspartate/asparagine hydroxylation site

IPR050751 Extracellular matrix structural protein

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR049883 NOTCH1 EGF-like calcium-binding domain
GlyGen

P37889 5 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 19

cDNA 13

Primer pair 2

Other 4

Microarray probesets 2

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MGD-MRK-9716, MGI:1922089

Summaries

All 80

Developmental Gene Expression 24

Gene Ontology 9

Phenotypes 15
Earliest

J:16328 Pan TC, et al., Structure and expression of fibulin-2, a novel extracellular matrix protein with multiple EGF-like repeats and consensus motifs for calcium binding. J Cell Biol. 1993 Dec;123(5):1269-77
Latest

J:345584 Mohamedi Y, et al., Lung Inflammatory Phenotype in Mice Deficient in Fibulin-2 and ADAMTS-12. Int J Mol Sci. 2024 Feb 7;25(4)

TSS for Fbln2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57703	Chr6:91189769-91189780 (+)	333 bp
Tssr57704	Chr6:91189781-91189826 (+)	362 bp
Tssr57705	Chr6:91189841-91189852 (+)	405 bp
Tssr57706	Chr6:91210192-91210201 (+)	20,755 bp
Tssr57707	Chr6:91210460-91210474 (+)	21,025 bp
Tssr57708	Chr6:91210478-91210489 (+)	21,042 bp
Tssr1937	Chr6:91210524-91210534 (+)	21,087 bp
Tssr57709	Chr6:91210734-91210750 (+)	21,300 bp
Tssr57710	Chr6:91210776-91210788 (+)	21,340 bp
Tssr57711	Chr6:91211000-91211009 (+)	21,563 bp
Tssr57712	Chr6:91211198-91211219 (+)	21,767 bp
Tssr57713	Chr6:91211272-91211283 (+)	21,836 bp
Tssr57714	Chr6:91229555-91229558 (+)	40,115 bp
Tssr57715	Chr6:91242860-91242874 (+)	53,425 bp
Tssr57716	Chr6:91242912-91242919 (+)	53,474 bp
Tssr57717	Chr6:91242928-91242941 (+)	53,493 bp
Tssr57718	Chr6:91242944-91242954 (+)	53,507 bp
Tssr57719	Chr6:91247012-91247036 (+)	57,582 bp
Tssr57720	Chr6:91249083-91249095 (+)	59,647 bp
Tssr57721	Chr6:91249452-91249465 (+)	60,017 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24