Fbp1 MGI Mouse Gene Detail - MGI:95492 - fructose bisphosphatase 1

Symbol

Fbp1
Name

fructose bisphosphatase 1
Synonyms

Fbp-2, Fbp3, FBPase brain isoform, FBPase liver

Feature Type

protein coding gene
IDs

MGI:95492
NCBI Gene: 14121
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr13:63012567-63036096 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 32.74 cM, cytoband B3-C1
Mapping Data

5 experiments

SNPs within 2kb

882 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95492	protein coding gene	Chr13:63012567-63036112 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020667	protein coding gene	Chr13:62794578-62817684 (-)
A/J	MGP_AJ_G0020621	protein coding gene	Chr13:60538676-60561799 (-)
AKR/J	MGP_AKRJ_G0020598	protein coding gene	Chr13:62557489-62581021 (-)
BALB/cJ	MGP_BALBcJ_G0020619	protein coding gene	Chr13:60956221-60979350 (-)
C3H/HeJ	MGP_C3HHeJ_G0020414	protein coding gene	Chr13:62096392-62120670 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021053	protein coding gene	Chr13:64860030-64883553 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018631	protein coding gene	Chr13:58217632-58241282 (-)
CAST/EiJ	MGP_CASTEiJ_G0019930	protein coding gene	Chr13:62082081-62105469 (-)
CBA/J	MGP_CBAJ_G0020374	protein coding gene	Chr13:67349049-67372584 (-)
DBA/2J	MGP_DBA2J_G0020499	protein coding gene	Chr13:60380807-60404695 (-)
FVB/NJ	MGP_FVBNJ_G0020478	protein coding gene	Chr13:59492949-59516472 (-)
LP/J	MGP_LPJ_G0020573	protein coding gene	Chr13:63091615-63115442 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020507	protein coding gene	Chr13:66365640-66388854 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021097	protein coding gene	Chr13:61856326-61880936 (-)
PWK/PhJ	MGP_PWKPhJ_G0019684	protein coding gene	Chr13:59927447-59951558 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019511	protein coding gene	Chr13:60017255-60042696 (-)
WSB/EiJ	MGP_WSBEiJ_G0019991	protein coding gene	Chr13:62363582-62387103 (-)

Human Ortholog

FBP1, fructose-bisphosphatase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBP1, fructose-bisphosphatase 1
Synonyms

FBP
Links

HGNC:3606

NCBI Gene ID: 2203

neXtProt AC: NX_P09467

UniProt: P09467
Chr Location

9q22.32; chr9:94603133-94640263 (-) GRCh38

MGI Vertebrate Homology

Fbp1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FBP1
Protein SuperFamily

FBPtase_SBPase
Gene Tree

Fbp1

Diseases

1 with human FBP1 associations

				Human Disease	Mouse Models
				fructose-1,6-bisphosphatase deficiency IDs fructose-1,6-bisphosphatase deficiency DOID:5204 ICD10CM:E74.19 MESH:D015319 NCI:C128119 OMIM:229700 UMLS_CUI:C0016756

Click on a disease name to see all genes associated with that disease.

less

Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

4
Genomic Mutations

1 involving Fbp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for an ENU-induced allele exhibit reduced fasting glucose levels.

less

All GO Annotations

60
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1050
Tissues

318
cDNA Data

292
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbp1

ZFIN fbp1a

less

All Sequences

54
RefSeq

9
UniProt

3
CCDS

CCDS26590.1

Ensembl

ENSMUSG00000069805 (Evidence)
NCBI Gene

14121

			Length	Strain/Species	Flank
genomic	ENSMUSG00000069805	Ensembl Gene Model \| MGI Sequence Detail	23530	C57BL/6J	± kb
transcript	ENSMUST00000092888	Ensembl \| MGI Sequence Detail	1479	Not Applicable
polypeptide	ENSMUSP00000090564	Ensembl \| MGI Sequence Detail	338	Not Applicable

less

UniProt

3 Sequences
Protein Ontology

PR:000007365 fructose-1,6-bisphosphatase 1

(term hierarchy)
EC

3.1.3.11
InterPro Domains

IPR028343 Fructose-1,6-bisphosphatase

IPR020548 Fructose-1,6-bisphosphatase, active site

IPR000146 Fructose-1,6-bisphosphatase class 1

IPR044015 Fructose-1-6-bisphosphatase class 1, C-terminal

IPR033391 Fructose-1-6-bisphosphatase class I, N-terminal
GlyGen

Q9QXD6 1 site, 1 O-linked glycan (1 site)

less

All nucleic 298

Genomic 3

cDNA 292

Primer pair 3

Microarray probesets 3

less

MGD-MRK-9720, MGD-MRK-9722, MGI:1330236

Summaries

All 64

Developmental Gene Expression 19

Gene Ontology 7

Phenotypes 12
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:353820 Gu L, et al., Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness. Cell Metab. 2023 Apr 12;

TSS for Fbp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122966	Chr13:63036194-63036207 (-)	-105 bp
Tssr122965	Chr13:63035967-63035982 (-)	121 bp
Tssr122964	Chr13:63035941-63035963 (-)	144 bp
Tssr122962	Chr13:63015179-63015199 (-)	20,907 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24