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Fcer1a Gene Detail
Summary
  • Symbol
    Fcer1a
  • Name
    Fc receptor, IgE, high affinity I, alpha polypeptide
  • Synonyms
    Fce1a, FcERI, Fcr-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:95494
    NCBI Gene: 14125
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:173048851-173054781 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 80.33 cM
  • Mapping Data
    28 experiments
Strain
Comparison
more
  • SNPs within 2kb
    246 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95494
 protein coding gene Chr1:173048836-173054799 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016803
 protein coding gene Chr1:179134983-179140909 (-)
A/J MGP_AJ_G0016782
 protein coding gene Chr1:171789892-171795820 (-)
AKR/J MGP_AKRJ_G0016748
 protein coding gene Chr1:176981812-176987738 (-)
BALB/cJ MGP_BALBcJ_G0016743
 protein coding gene Chr1:172334688-172340614 (-)
C3H/HeJ MGP_C3HHeJ_G0016567
 protein coding gene Chr1:177551911-177557837 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017205
 protein coding gene Chr1:185041692-185049204 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014911
 protein coding gene Chr1:163440853-163446581 (-)
CAST/EiJ MGP_CASTEiJ_G0016147
 protein coding gene Chr1:176939124-176945054 (-)
CBA/J MGP_CBAJ_G0016541
 protein coding gene Chr1:191680317-191686243 (-)
DBA/2J MGP_DBA2J_G0016648
 protein coding gene Chr1:170722003-170727929 (-)
FVB/NJ MGP_FVBNJ_G0016645
 protein coding gene Chr1:168969631-168975559 (-)
LP/J MGP_LPJ_G0016719
 protein coding gene Chr1:180180428-180186354 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016672
 protein coding gene Chr1:198918278-198927449 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017241
 protein coding gene Chr1:176881438-176887364 (-)
PWK/PhJ MGP_PWKPhJ_G0015933
 protein coding gene Chr1:170106223-170112185 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015715
 protein coding gene Chr1:175808470-175814390 (-)
WSB/EiJ MGP_WSBEiJ_G0016209
 protein coding gene Chr1:177012181-177018108 (-)



Homology
more
  • Human Ortholog
    FCER1A, Fc epsilon receptor Ia
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FCER1A, Fc epsilon receptor Ia
  • Synonyms
    FCE1A, FcERI, FCERIA
  • Links
    NCBI Gene ID: 2205
    neXtProt AC: NX_P12319
    UniProt: P12319

  • Chr Location
    1q23.2; chr1:159283575-159308224 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal mast cell physiology and altered susceptibility to type I hypersensitivity reaction. Mice homozygous for another knock-out allele display altered development of allergic airway inflammation and airway hyperresponsiveness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    44
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    6
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005339 Ensembl Gene Model | MGI Sequence Detail 5931 C57BL/6J ±  kb
    transcript ENSMUST00000049706 Ensembl | MGI Sequence Detail 998 Not Applicable  
    polypeptide ENSMUSP00000056882 Ensembl | MGI Sequence Detail 250 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 21
      cDNA 9
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9724, MGD-MRK-9728, MGD-MRK-9741
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 63
    • Earliest
      J:8867 Kinet JP, et al., A cDNA presumptively coding for the alpha subunit of the receptor with high affinity for immunoglobulin E [published erratum appears in Biochemistry 1988 Nov 15;27(23):8694]. Biochemistry. 1987 Jul 28;26(15):4605-10
    • Latest
      J:343560 Kimura M, et al., A nerve-goblet cell association promotes allergic conjunctivitis through rapid antigen passage. JCI Insight. 2023 Nov 8;8(21)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory