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Fgf6 Gene Detail
Summary
  • Symbol
    Fgf6
  • Name
    fibroblast growth factor 6
  • Synonyms
    Fgf-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:95520
    NCBI Gene: 14177
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr6:126992505-127001681 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 61.92 cM, cytoband F3-G1
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    230 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95520
 protein coding gene Chr6:126992505-127005150 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031310
 protein coding gene Chr6:130495476-130508064 (+)
A/J MGP_AJ_G0031281
 protein coding gene Chr6:125539532-125552111 (+)
AKR/J MGP_AKRJ_G0031209
 protein coding gene Chr6:128930862-128946323 (+)
BALB/cJ MGP_BALBcJ_G0031288
 protein coding gene Chr6:125099594-125112260 (+)
C3H/HeJ MGP_C3HHeJ_G0031012
 protein coding gene Chr6:129053727-129067567 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031745
 protein coding gene Chr6:133898996-133913291 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028893
 protein coding gene Chr6:122714615-122727207 (+)
CAST/EiJ MGP_CASTEiJ_G0030393
 protein coding gene Chr6:129249641-129263102 (+)
CBA/J MGP_CBAJ_G0030973
 protein coding gene Chr6:139042265-139057722 (+)
DBA/2J MGP_DBA2J_G0031129
 protein coding gene Chr6:124425910-124438801 (+)
FVB/NJ MGP_FVBNJ_G0031078
 protein coding gene Chr6:123354346-123366964 (+)
LP/J MGP_LPJ_G0031209
 protein coding gene Chr6:130606266-130618807 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031117
 protein coding gene Chr6:143009150-143022849 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031780
 protein coding gene Chr6:128884784-128898129 (+)
PWK/PhJ MGP_PWKPhJ_G0030108
 protein coding gene Chr6:122691519-122704469 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029937
 protein coding gene Chr6:126960434-126973059 (+)
WSB/EiJ MGP_WSBEiJ_G0030478
 protein coding gene Chr6:129244968-129259528 (+)



Homology
more
  • Human Ortholog
    FGF6, fibroblast growth factor 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGF6, fibroblast growth factor 6
  • Synonyms
    HBGF-6, HST2
  • Links
    NCBI Gene ID: 2251
    neXtProt AC: NX_P10767
    UniProt: P10767

  • Chr Location
    12p13.32; chr12:4428155-4445815 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations appear phenotypically normal, but exhibit a defect in skeletal muscle regeneration following injury. Mutant myoblasts show decreased migrational ability.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    19
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1068
  • Tissues
    286
  • cDNA Data
    14
  • Literature Summary
    40
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14177 NCBI Gene Model | MGI Sequence Detail 9177 C57BL/6J ±  kb
    transcript NM_010204 RefSeq | MGI Sequence Detail 1232 ZRU/MplStud  
    polypeptide P21658 UniProt | EBI | MGI Sequence Detail 208 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 16
      cDNA 15
      Primer pair 11
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9765, MGD-MRK-9771
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 40
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:9708 Marics I, et al., Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family. Oncogene. 1989 Mar;4(3):335-40
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory