Fgr MGI Mouse Gene Detail - MGI:95527 - FGR proto-oncogene, Src family tyrosine kinase

Symbol

Fgr
Name

FGR proto-oncogene, Src family tyrosine kinase
Synonyms

Ali18, Mhdaali18

Feature Type

protein coding gene
IDs

MGI:95527
NCBI Gene: 14191
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr4:132701406-132729204 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 66.11 cM
Mapping Data

21 experiments

SNPs within 2kb

990 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95527	protein coding gene	Chr4:132701406-132729221 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028884	protein coding gene	Chr4:135182147-135215364 (+)
A/J	MGP_AJ_G0028843	protein coding gene	Chr4:129546280-129576540 (+)
AKR/J	MGP_AKRJ_G0028796	protein coding gene	Chr4:133208886-133238901 (+)
BALB/cJ	MGP_BALBcJ_G0028866	protein coding gene	Chr4:130164163-130191861 (+)
C3H/HeJ	MGP_C3HHeJ_G0028580	protein coding gene	Chr4:133460557-133491116 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029308	protein coding gene	Chr4:140040017-140075466 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026579	protein coding gene	Chr4:122619404-122648170 (+)
CAST/EiJ	MGP_CASTEiJ_G0028013	protein coding gene	Chr4:131553529-131586145 (+)
CBA/J	MGP_CBAJ_G0028546	protein coding gene	Chr4:143653531-143689347 (+)
DBA/2J	MGP_DBA2J_G0028695	protein coding gene	Chr4:129965029-129993783 (+)
FVB/NJ	MGP_FVBNJ_G0028662	protein coding gene	Chr4:128826724-128855308 (+)
LP/J	MGP_LPJ_G0028796	protein coding gene	Chr4:135318015-135346506 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028688	protein coding gene	Chr4:148239869-148269188 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029346	protein coding gene	Chr4:133618421-133652046 (+)
PWK/PhJ	MGP_PWKPhJ_G0027734	protein coding gene	Chr4:126665819-126694885 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027560	protein coding gene	Chr4:129477934-129509078 (+)
WSB/EiJ	MGP_WSBEiJ_G0028093	protein coding gene	Chr4:133790894-133824633 (+)

Human Ortholog

FGR, FGR proto-oncogene, Src family tyrosine kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FGR, FGR proto-oncogene, Src family tyrosine kinase
Synonyms

c-fgr, c-src2, p55c-fgr, p55-Fgr, p58c-fgr, p58-Fgr, SRC2
Links

HGNC:3697

NCBI Gene ID: 2268

neXtProt AC: NX_P09769

UniProt: P09769
Chr Location

1p35.3; chr1:27612064-27635185 (-) GRCh38

MGI Vertebrate Homology

Fgr stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FGR
Gene Tree

Fgr

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Phenotype Summary

19 phenotypes from 3 alleles in 6 genetic backgrounds
7 phenotypes from multigenic genotypes
3 images
68 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

115
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

104
Radiation induced

1
Targeted

3
Genomic Mutations

4 involving Fgr
Incidental Mutations

CvDC
Find Mice (IMSR)

132 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit a partial reduction in hemorrhage following induction of a local Shwartzman reaction, and show enhanced NK-cell receptor-induced IFN-gamma production in natural killer (NK) cells.

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All GO Annotations

54
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

727
Tissues

21
cDNA Data

20
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fgr

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All Sequences

46
RefSeq

6
UniProt

2
CCDS

CCDS18739.1

Ensembl

ENSMUSG00000028874 (Evidence)
NCBI Gene

14191

			Length	Strain/Species	Flank
genomic	14191	NCBI Gene Model \| MGI Sequence Detail	27799	C57BL/6J	± kb
transcript	NM_010208	RefSeq \| MGI Sequence Detail	3353	ZRU/MplStud
polypeptide	P14234	UniProt \| EBI \| MGI Sequence Detail	517	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007510 tyrosine-protein kinase Fgr

(term hierarchy)
EC

2.7.10.2
InterPro Domains

IPR050198 Non-receptor tyrosine kinases involved in cell signaling

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR035693 Tyrosine-protein kinase Fgr, SH2 domain

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All nucleic 27

Genomic 4

cDNA 21

Primer pair 1

Other 1

Microarray probesets 5

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MGD-MRK-9787, MGI:3665435

Summaries

All 131

Developmental Gene Expression 3

Gene Ontology 14

Phenotypes 68
Earliest

J:7829 Parker RC, et al., Isolation of duplicated human c-src genes located on chromosomes 1 and 20. Mol Cell Biol. 1985 Apr;5(4):831-8
Latest

J:335773 Futosi K, et al., Analysis of intracellular tyrosine phosphorylation in circulating neutrophils as a rapid assay for the in vivo effect of oral tyrosine kinase inhibitors. Front Pharmacol. 2023;14:1056154

TSS for Fgr:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39429	Chr4:132699646-132699654 (+)	-1,756 bp
Tssr39430	Chr4:132701404-132701407 (+)	0 bp
Tssr39431	Chr4:132701434-132701466 (+)	44 bp
Tssr39432	Chr4:132701468-132701473 (+)	65 bp
Tssr39433	Chr4:132701483-132701507 (+)	89 bp
Tssr39434	Chr4:132701513-132701528 (+)	115 bp
Tssr39435	Chr4:132705067-132705076 (+)	3,666 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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