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Fkbp4 Gene Detail
Summary
  • Symbol
    Fkbp4
  • Name
    FK506 binding protein 4
  • Synonyms
    FKBP-52, FKBP52
  • Feature Type
    protein coding gene
  • IDs
    MGI:95543
    NCBI Gene: 14228
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:128407066-128415619 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.00 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    292 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95543
 protein coding gene Chr6:128406698-128415640 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031327
 protein coding gene Chr6:132042848-132051775 (-)
A/J MGP_AJ_G0031298
 protein coding gene Chr6:126974417-126983856 (-)
AKR/J MGP_AKRJ_G0031226
 protein coding gene Chr6:130391023-130400011 (-)
BALB/cJ MGP_BALBcJ_G0031305
 protein coding gene Chr6:126547187-126556134 (-)
C3H/HeJ MGP_C3HHeJ_G0031029
 protein coding gene Chr6:130532315-130542085 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031764
 protein coding gene Chr6:135472608-135481331 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028910
 protein coding gene Chr6:124180615-124189710 (-)
CAST/EiJ MGP_CASTEiJ_G0030410
 protein coding gene Chr6:130827483-130836647 (-)
CBA/J MGP_CBAJ_G0030990
 protein coding gene Chr6:140706047-140716484 (-)
DBA/2J MGP_DBA2J_G0031146
 protein coding gene Chr6:125872893-125881900 (-)
FVB/NJ MGP_FVBNJ_G0031096
 protein coding gene Chr6:124798729-124807811 (-)
LP/J MGP_LPJ_G0031226
 protein coding gene Chr6:132158775-132167745 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031134
 protein coding gene Chr6:144537724-144547622 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031797
 protein coding gene Chr6:130405275-130414210 (-)
PWK/PhJ MGP_PWKPhJ_G0030125
 protein coding gene Chr6:124166192-124175876 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029954
 protein coding gene Chr6:128527144-128538657 (-)
WSB/EiJ MGP_WSBEiJ_G0030495
 protein coding gene Chr6:130804354-130813083 (-)



Homology
more
  • Human Ortholog
    FKBP4, FKBP prolyl isomerase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FKBP4, FKBP prolyl isomerase 4
  • Synonyms
    FKBP51, FKBP52, FKBP59, HBI, Hsp56, p52, PPIase
  • Links
    NCBI Gene ID: 2288
    neXtProt AC: NX_Q02790
    UniProt: Q02790

  • Chr Location
    12p13.33; chr12:2794970-2805423 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Fkbp4 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    61 phenotypes from 3 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    2 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null males show reproductive tissue defects consistent with androgen insensitivity such as ambiguous external genitalia, dysgenic prostate, malformed seminal gland and cryptorchism. Males also exhibit hypospadia and infertility. Females are sterile due to failure of implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    5
  • cDNA Data
    15
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14228 NCBI Gene Model | MGI Sequence Detail 8554 C57BL/6J ±  kb
    transcript NM_010219 RefSeq | MGI Sequence Detail 2212 C57BL/6  
    polypeptide P30416 UniProt | EBI | MGI Sequence Detail 458 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007540 peptidyl-prolyl cis-trans isomerase FKBP4
      (term hierarchy)
    • EC
      5.2.1.8
    • InterPro Domains
      IPR050689 FKBP-type Peptidyl-prolyl cis-trans Isomerase
      IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
      IPR050754 Immunophilin FKBP-type domain-containing protein
      IPR046357 Peptidyl-prolyl cis-trans isomerase domain superfamily
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
      IPR013105 Tetratricopeptide repeat 2
    • GlyGen
      P30416 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9812, MGI:2141664, MGI:2147626
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 14
      Phenotypes 26
    • Earliest
      J:10145 Kuhner MK, et al., DNA sequences of mouse H-2 and Qa genes. Immunogenetics. 1989;30(6):458-64
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory