Flg MGI Mouse Gene Detail - MGI:95553

Symbol

Flg
Name

filaggrin
Synonyms

fillagrin, ft, profilaggrin

Feature Type

protein coding gene
IDs

MGI:95553
NCBI Gene: 14246
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr3:93180853-93200996 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.16 cM
Mapping Data

28 experiments

SNPs within 2kb

257 from dbSNP Build 142
Strain Annotations

17
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95553	protein coding gene	Chr3:93180830-93200996 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027532	protein coding gene	Chr3:93763341-93770469 (+)
A/J	MGP_AJ_G0027497	protein coding gene	Chr3:90860490-90867271 (+)
AKR/J	MGP_AKRJ_G0027465	protein coding gene	Chr3:92945792-92952545 (+)
BALB/cJ	MGP_BALBcJ_G0027506	protein coding gene	Chr3:90608094-90614883 (+)
C3H/HeJ	MGP_C3HHeJ_G0027244	protein coding gene	Chr3:93170502-93177283 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027949	protein coding gene	Chr3:97335831-97342621 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025297	protein coding gene	Chr3:87444042-87463615 (+)
CAST/EiJ	MGP_CASTEiJ_G0026692	protein coding gene	Chr3:92604257-92613800 (+)
CBA/J	MGP_CBAJ_G0027220	protein coding gene	Chr3:100712888-100721759 (+)
DBA/2J	MGP_DBA2J_G0027357	protein coding gene	Chr3:90152395-90156963 (+)
FVB/NJ	MGP_FVBNJ_G0027326	protein coding gene	Chr3:88281453-88288274 (+)
LP/J	MGP_LPJ_G0027466	protein coding gene	Chr3:94998633-95005417 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027352	protein coding gene	Chr3:106978471-106986223 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028008	protein coding gene	Chr3:92682114-92688900 (+)
PWK/PhJ	no annotation
SPRET/EiJ	MGP_SPRETEiJ_G0026240	protein coding gene	Chr3:91019786-91026533 (+)
WSB/EiJ	MGP_WSBEiJ_G0026774	protein coding gene	Chr3:93056262-93066924 (+)

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Gene Tree

Flg

Diseases

1 with Flg mouse models

Human Disease

Mouse Models

atopic dermatitis 2

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

49 phenotypes from 2 alleles in 7 genetic backgrounds
20 phenotypes from multigenic genotypes
45 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Spontaneous

1
Targeted

2
Genomic Mutations

2 involving Flg
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutations in this gene produce abnormalities in the skin of the ear, tail and dorsal trunk.

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All GO Annotations

7
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

952
Tissues

50
cDNA Data

8
Literature Summary

146

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

61
RefSeq

2
UniProt

11

Ensembl

ENSMUSG00000102439 (Evidence)
NCBI Gene

14246

			Length	Strain/Species	Flank
genomic	14246	NCBI Gene Model \| MGI Sequence Detail	20144	C57BL/6J	± kb
transcript	AK137664	GenBank \| ENA \| DDBJ \| MGI Sequence Detail	4523	C57BL/6J
polypeptide	P11088	UniProt \| EBI \| MGI Sequence Detail	336	Not Applicable

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UniProt

11 Sequences
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR003303 Filaggrin

IPR034325 S-100

IPR013787 S100/CaBP-9k-type, calcium binding, subdomain

IPR001751 S100/Calcium binding protein 7/8-like, conserved site

IPR052503 S100-fused Epidermal Structural Protein

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All nucleic 20

Genomic 3

cDNA 8

Primer pair 7

Other 2

Microarray probesets 3

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MGD-MRK-9823, MGD-MRK-9881, MGI:2139967, MGI:95587

Summaries

All 235

Developmental Gene Expression 146

Diseases 2

Gene Ontology 9

Phenotypes 45
Earliest

J:5286 Lane PW, Two new mutations in linkage group XVI of the house mouse. Flaky tail and varitint-waddler-J. J Hered. 1972 May-Jun;63(3):135-40
Latest

J:355461 Deng Z, et al., Single-cell transcriptomics reveals the cellular identity of a novel progenitor population crucial for murine neural tube closure. Heliyon. 2024 Sep 15;10(17):e37259

TSS for Flg:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30321	Chr3:93180826-93180831 (+)	-24 bp
Tssr30327	Chr3:93186699-93186710 (+)	5,852 bp
Tssr30328	Chr3:93186761-93186821 (+)	5,938 bp
Tssr30329	Chr3:93186833-93186841 (+)	5,984 bp
Tssr30330	Chr3:93186853-93186864 (+)	6,006 bp
Tssr959	Chr3:93186866-93186874 (+)	6,017 bp
Tssr30331	Chr3:93186888-93186914 (+)	6,048 bp
Tssr30332	Chr3:93186915-93186918 (+)	6,064 bp
Tssr30333	Chr3:93187013-93187025 (+)	6,166 bp
Tssr30334	Chr3:93200366-93200373 (+)	19,517 bp
Tssr30335	Chr3:93200386-93200405 (+)	19,543 bp
Tssr30336	Chr3:93200415-93200426 (+)	19,568 bp
Tssr30337	Chr3:93200439-93200454 (+)	19,594 bp
Tssr30338	Chr3:93200473-93200493 (+)	19,630 bp
Tssr30339	Chr3:93200633-93200640 (+)	19,784 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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