fm Gene Detail

Summary

• Symbol
  fm
• Name
  foam cell reticulosis

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:95563
  NCBI Gene: 14259
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome Unknown

Human Diseases

• Diseases
  1 with fm mouse models

Human Disease

Mouse Models

Niemann-Pick disease

IDs

Niemann-Pick disease      

DOID:14504
DOID:0050442
DOID:0050443
DOID:14770
ICD10CM:E75.24
MESH:D009542
NCI:C61269
UMLS_CUI:C0028064

View 1 model

Mouse Models

Human Disease Modeled: Niemann-Pick disease

Allelic Composition	Genetic Background	Reference	Phenotypes
fm/fm	involves: CBA/H	J:5696	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  22 phenotypes from 1 allele in 1 genetic background
  6 phenotype references
  

• All Mutations and Alleles
  1
• Spontaneous
  1
• Find Mice (IMSR)
  0 strains or lines available

Mutations in this gene result in the replacement of lymphoid tissue of the thymus, Peyer's patches, and to a lesser extent other tissues, by lipid-containing foam cells.

Sequences &
Gene Models

• NCBI Gene
  14259

Other
Accession IDs

MGD-MRK-9841

References

• Summaries
  All 7

  Diseases 1

  Phenotypes 6
• Earliest
  J:275 Lyon MF, et al., Foam-cell reticulosis of mice: an inherited condition resembling Gaucher's and Niemann-Pick diseases. J Med Genet. 1965 Jun;2:99-106
• Latest
  J:5696 Adachi M, et al., Animal model of human disease: Niemann-Pick Disease type C. Am J Pathol. 1976 Oct;85(1):229-31