Folr1 MGI Mouse Gene Detail - MGI:95568

Symbol

Folr1
Name

folate receptor alpha
Synonyms

FBP1, folate-binding protein 1, folate receptor [a], Folbp-1, Folbp1

Feature Type

protein coding gene
IDs

MGI:95568
NCBI Gene: 14275
Alliance

gene page
Transcription Start Sites

25 TSS

Sequence Map

Chr7:101507551-101519974 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.67 cM
Mapping Data

4 experiments

SNPs within 2kb

413 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95568	protein coding gene	Chr7:101507538-101519995 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032590	protein coding gene	Chr7:104870039-104884081 (-)
A/J	MGP_AJ_G0032566	protein coding gene	Chr7:102201541-102213934 (-)
AKR/J	MGP_AKRJ_G0032502	protein coding gene	Chr7:104647503-104660100 (-)
BALB/cJ	MGP_BALBcJ_G0032577	protein coding gene	Chr7:101900890-101913390 (-)
C3H/HeJ	MGP_C3HHeJ_G0032291	protein coding gene	Chr7:105020855-105033567 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033074	protein coding gene	Chr7:108820929-108835940 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030068	protein coding gene	Chr7:104557405-104571872 (-)
CAST/EiJ	MGP_CASTEiJ_G0031617	protein coding gene	Chr7:96574999-96587353 (-)
CBA/J	MGP_CBAJ_G0032257	protein coding gene	Chr7:112585904-112600583 (-)
DBA/2J	MGP_DBA2J_G0032409	protein coding gene	Chr7:100529397-100541838 (-)
FVB/NJ	MGP_FVBNJ_G0032365	protein coding gene	Chr7:100310859-100323299 (-)
LP/J	MGP_LPJ_G0032498	protein coding gene	Chr7:106187919-106200321 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032399	protein coding gene	Chr7:113923846-113936832 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033096	protein coding gene	Chr7:103914896-103929333 (-)
PWK/PhJ	MGP_PWKPhJ_G0031335	protein coding gene	Chr7:93640731-93653627 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031179	protein coding gene	Chr7:91200567-91216435 (-)
WSB/EiJ	MGP_WSBEiJ_G0031734	protein coding gene	Chr7:104601965-104614368 (-)

Human Ortholog

FOLR1, folate receptor alpha

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FOLR1, folate receptor alpha
Synonyms

FBP, FOLR, FRalpha, NCFTD
Links

HGNC:3791

NCBI Gene ID: 2348

neXtProt AC: NX_P15328

UniProt: P15328
Chr Location

11q13.4; chr11:72189558-72196323 (+) GRCh38

MGI Vertebrate Homology

Folr1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FOLR1
Gene Tree

Folr1

Diseases

1 with human FOLR1 associations

				Human Disease	Mouse Models
				cerebral folate receptor alpha deficiency IDs cerebral folate receptor alpha deficiency DOID:0050719 OMIM:613068

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

26 phenotypes from 2 alleles in 3 genetic backgrounds
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

293
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

285
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Folr1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

216 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Embryos homozygous for a knock-out allele are growth retarded and malformed, show multiple developmental anomalies, including neural and craniofacial defects, and die by E10. Folate supplementation of pregnant dams reduces embryonic mortality and improves many of the adverse developmental effects.

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All GO Annotations

40
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1001
Tissues

173
cDNA Data

15
Literature Summary

18

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase folr1

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All Sequences

121
RefSeq

40
UniProt

11
CCDS

CCDS21517.1

Ensembl

ENSMUSG00000001827 (Evidence)
NCBI Gene

14275

			Length	Strain/Species	Flank
genomic	14275	NCBI Gene Model \| MGI Sequence Detail	12424	C57BL/6J	± kb
transcript	NM_001412432	RefSeq \| MGI Sequence Detail	1615	C57BL/6
polypeptide	P35846	UniProt \| EBI \| MGI Sequence Detail	255	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000007594 folate receptor alpha

(term hierarchy)
InterPro Domains

IPR004269 Folate receptor

IPR018143 Folate receptor-like
GlyGen

P35846 3 sites, 2 N-linked glycans (2 sites)

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All nucleic 19

cDNA 15

Primer pair 4

Microarray probesets 6

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MGD-MRK-9854, MGD-MRK-9856

Summaries

All 94

Developmental Gene Expression 18

Gene Ontology 12

Phenotypes 37
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Folr1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73880	Chr7:101520008-101520014 (-)	-37 bp
Tssr73879	Chr7:101519985-101519994 (-)	-16 bp
Tssr73878	Chr7:101519973-101519984 (-)	-5 bp
Tssr73877	Chr7:101519918-101519963 (-)	33 bp
Tssr73876	Chr7:101519894-101519914 (-)	70 bp
Tssr73875	Chr7:101519864-101519883 (-)	100 bp
Tssr73874	Chr7:101519838-101519853 (-)	128 bp
Tssr73873	Chr7:101519813-101519819 (-)	158 bp
Tssr73872	Chr7:101518556-101518565 (-)	1,413 bp
Tssr73871	Chr7:101518514-101518551 (-)	1,441 bp
Tssr73870	Chr7:101518499-101518509 (-)	1,470 bp
Tssr73869	Chr7:101518464-101518484 (-)	1,500 bp
Tssr73868	Chr7:101518441-101518463 (-)	1,522 bp
Tssr73867	Chr7:101518413-101518437 (-)	1,549 bp
Tssr73866	Chr7:101518241-101518280 (-)	1,713 bp
Tssr73865	Chr7:101518219-101518230 (-)	1,749 bp
Tssr73864	Chr7:101517931-101517932 (-)	2,042 bp
Tssr73863	Chr7:101517879-101517907 (-)	2,081 bp
Tssr73862	Chr7:101517716-101517729 (-)	2,251 bp
Tssr73861	Chr7:101517654-101517705 (-)	2,294 bp
Tssr73860	Chr7:101516598-101516627 (-)	3,361 bp
Tssr73859	Chr7:101516504-101516545 (-)	3,449 bp
Tssr73858	Chr7:101515977-101515988 (-)	3,991 bp
Tssr73857	Chr7:101513367-101513375 (-)	6,603 bp
Tssr73856	Chr7:101513300-101513363 (-)	6,642 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24