Fos MGI Mouse Gene Detail - MGI:95574 - FBJ osteosarcoma oncogene

Symbol

Fos
Name

FBJ osteosarcoma oncogene
Synonyms

c-fos, cFos, D12Rfj1

Feature Type

protein coding gene
IDs

MGI:95574
NCBI Gene: 14281
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr12:85520664-85524047 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 39.70 cM
Mapping Data

28 experiments

SNPs within 2kb

115 from dbSNP Build 142
Strain Annotations

18
PCR

2
RFLP

11

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95574	protein coding gene	Chr12:85520664-85524048 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019961	protein coding gene	Chr12:86250395-86253782 (+)
A/J	MGP_AJ_G0019918	protein coding gene	Chr12:82976420-82979796 (+)
AKR/J	MGP_AKRJ_G0019894	protein coding gene	Chr12:85225204-85228584 (+)
BALB/cJ	MGP_BALBcJ_G0019898	protein coding gene	Chr12:83319320-83322700 (+)
C3H/HeJ	MGP_C3HHeJ_G0019704	protein coding gene	Chr12:85698730-85702106 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020349	protein coding gene	Chr12:88741461-88744847 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017967	protein coding gene	Chr12:79863165-79866562 (+)
CAST/EiJ	MGP_CASTEiJ_G0019254	protein coding gene	Chr12:80670271-80673658 (+)
CBA/J	MGP_CBAJ_G0019675	protein coding gene	Chr12:92124639-92128015 (+)
DBA/2J	MGP_DBA2J_G0019789	protein coding gene	Chr12:82491708-82495095 (+)
FVB/NJ	MGP_FVBNJ_G0019776	protein coding gene	Chr12:81460731-81464107 (+)
LP/J	MGP_LPJ_G0019863	protein coding gene	Chr12:86120205-86123623 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019815	protein coding gene	Chr12:94985433-94988822 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020382	protein coding gene	Chr12:84828657-84832033 (+)
PWK/PhJ	MGP_PWKPhJ_G0019017	protein coding gene	Chr12:77000518-77003963 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018813	protein coding gene	Chr12:79311599-79314974 (+)
WSB/EiJ	MGP_WSBEiJ_G0019306	protein coding gene	Chr12:85569791-85573167 (+)

Human Ortholog

FOS, Fos proto-oncogene, AP-1 transcription factor subunit

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FOS, Fos proto-oncogene, AP-1 transcription factor subunit
Synonyms

AP-1, C-FOS, p55
Links

HGNC:3796

NCBI Gene ID: 2353

neXtProt AC: NX_P01100

UniProt: P01100
Chr Location

14q24.3; chr14:75278826-75282230 (+) GRCh38

MGI Vertebrate Homology

Fos stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FOS
Gene Tree

Fos

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Phenotype Summary

120 phenotypes from 13 alleles in 14 genetic backgrounds
23 phenotypes from multigenic genotypes
4 images
268 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (other)

1
Endonuclease-mediated

10
Targeted

17
Transgenic

4
Genomic Mutations

1 involving Fos
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Null mutants are growth-retarded, most dying perinatally. Survivors have osteopetrosis and abnormal tooth eruption, gametogenesis, hemopoiesis, behavior and photoreceptor apoptosis. Hippocampal-specific mutants have seizures and highly excitable neurons.

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All GO Annotations

112
GO References

30

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1114
Tissues

268
cDNA Data

13
Literature Summary

117

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fos

ZFIN fosaa, fosab

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All Sequences

39
RefSeq

2
UniProt

3
CCDS

CCDS26059.1

Ensembl

ENSMUSG00000021250 (Evidence)
NCBI Gene

14281

			Length	Strain/Species	Flank
genomic	ENSMUSG00000021250	Ensembl Gene Model \| MGI Sequence Detail	3384	C57BL/6J	± kb
transcript	ENSMUST00000021674	Ensembl \| MGI Sequence Detail	2108	Not Applicable
polypeptide	ENSMUSP00000021674	Ensembl \| MGI Sequence Detail	380	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007597 protein c-Fos

(term hierarchy)
PDB

2WT7
InterPro Domains

IPR000837 AP-1 transcription factor

IPR004827 Basic-leucine zipper domain

IPR046347 Basic-leucine zipper domain superfamily
GlyGen

P01101 3 sites, 1 O-linked glycan (3 sites)

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All nucleic 49

Genomic 10

cDNA 18

Primer pair 16

Other 5

Microarray probesets 3

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MGD-MRK-19548, MGD-MRK-9866

Summaries

All 645

Developmental Gene Expression 117

Gene Ontology 30

Phenotypes 268
Earliest

J:6867 Muller R, et al., Differential expression of cellular oncogenes during pre- and postnatal development of the mouse. Nature. 1982 Oct 14;299(5884):640-4
Latest

J:359036 Lin ZJ, et al., Stimulation of an entorhinal-hippocampal extinction circuit facilitates fear extinction in a post-traumatic stress disorder model. J Clin Invest. 2024 Sep 24;134(22)

TSS for Fos:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114399	Chr12:85520657-85520670 (+)	0 bp
Tssr114400	Chr12:85521076-85521081 (+)	415 bp
Tssr3896	Chr12:85521384-85521408 (+)	732 bp
Tssr114401	Chr12:85521463-85521488 (+)	812 bp
Tssr114402	Chr12:85521491-85521513 (+)	838 bp
Tssr114403	Chr12:85522359-85522370 (+)	1,701 bp
Tssr3897	Chr12:85522564-85522570 (+)	1,903 bp
Tssr114404	Chr12:85523261-85523269 (+)	2,601 bp
Tssr114405	Chr12:85523367-85523423 (+)	2,731 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24