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Fosb Gene Detail
Summary
  • Symbol
    Fosb
  • Name
    FBJ osteosarcoma oncogene B
  • Feature Type
    protein coding gene
  • IDs
    MGI:95575
    NCBI Gene: 14282
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19036621-19043970 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.56 cM, cytoband A2-B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    193 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95575
 protein coding gene Chr7:19036621-19043976 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031770
 protein coding gene Chr7:17297480-17304801 (-)
A/J MGP_AJ_G0031746
 protein coding gene Chr7:16945672-16952993 (-)
AKR/J MGP_AKRJ_G0031672
 protein coding gene Chr7:17408501-17416186 (-)
BALB/cJ MGP_BALBcJ_G0031751
 protein coding gene Chr7:17148550-17155874 (-)
C3H/HeJ MGP_C3HHeJ_G0031473
 protein coding gene Chr7:17676358-17683679 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032217
 protein coding gene Chr7:18160456-18167782 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029283
 protein coding gene Chr7:18593884-18601237 (-)
CAST/EiJ MGP_CASTEiJ_G0030816
 protein coding gene Chr7:14077376-14084700 (-)
CBA/J MGP_CBAJ_G0031435
 protein coding gene Chr7:18832952-18840273 (-)
DBA/2J MGP_DBA2J_G0031590
 protein coding gene Chr7:16887867-16895406 (-)
FVB/NJ MGP_FVBNJ_G0031542
 protein coding gene Chr7:16749414-16756736 (-)
LP/J MGP_LPJ_G0031673
 protein coding gene Chr7:17613808-17621129 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031578
 protein coding gene Chr7:18682801-18690122 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032245
 protein coding gene Chr7:17016145-17023468 (-)
PWK/PhJ MGP_PWKPhJ_G0030540
 protein coding gene Chr7:13977044-13984450 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030367
 protein coding gene Chr7:11732315-11739650 (-)
WSB/EiJ MGP_WSBEiJ_G0030916
 protein coding gene Chr7:17235501-17242835 (-)



Homology
more
  • Human Ortholog
    FOSB, FosB proto-oncogene, AP-1 transcription factor subunit
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOSB, FosB proto-oncogene, AP-1 transcription factor subunit
  • Synonyms
    AP-1, G0S3, GOS3, GOSB
  • Links
    NCBI Gene ID: 2354
    neXtProt AC: NX_P53539
    UniProt: P53539

  • Chr Location
    19q13.32; chr19:45467995-45475179 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 5 alleles in 7 genetic backgrounds
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show impaired nurturing behavior, altered behavioral tolerance to repeated motor seizures, reduced NMDA-mediated synaptic currents, and altered paradoxical sleep. Aging mice homozygous for another null allele may exhibit occasional tonic-clonic or generalized seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    922
  • Tissues
    191
  • cDNA Data
    17
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14282 NCBI Gene Model | MGI Sequence Detail 7350 C57BL/6J ±  kb
    transcript NM_008036 RefSeq | MGI Sequence Detail 3783 ZRU/MplStud  
    polypeptide P13346 UniProt | EBI | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 18
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9867
    References
    more
    • Summaries
      All 120
      Developmental Gene Expression 18
      Gene Ontology 7
      Phenotypes 50
    • Earliest
      J:15672 Zerial M, et al., The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activity. EMBO J. 1989 Mar;8(3):805-13
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory