Fv4 Gene Detail

Summary

• Symbol
  Fv4
• Name
  Friend virus susceptibility 4
• Synonyms
  Akvr-1, Fv-4

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:95598
  NCBI Gene: 14352
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 12, Syntenic
• Mapping Data
  11 experiments

Strain
Comparison

• RFLP
  5

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from 1 allele in 1 genetic background
  1 phenotype from multigenic genotypes
  9 phenotype references
  

• All Mutations and Alleles
  1
• Spontaneous
  1
• Find Mice (IMSR)
  2 strains or lines available

Strain G and wild mice have a dominant resistant allele to AKR and NB-tropic, but not amphotropic, leukemia viruses. DNA of these mice hybridizes to ecotropic env-gene probes suggesting resistance via a gp70 related protein binding to exogenous virus. DBA/2, BALB/c and most inbreds are susceptible.

Expression

• Other Mouse Links
  GEO

Sequences &
Gene Models

• All Sequences
  2
• UniProt
  1

• NCBI Gene
  14352

Representative Sequences			Length	Strain/Species
genomic	AH001894	GenBank | ENA | DDBJ | MGI Sequence Detail	3609	BALB/c (Fu-r-4w) congenic*
polypeptide	P11370	UniProt | EBI | MGI Sequence Detail	679	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• Protein Ontology
  PR:000007741 retrovirus-related Env polyprotein from Fv-4 locus
  (term hierarchy)

Molecular
Reagents

• All nucleic 13

  Genomic 11

  Other 2

Other
Accession IDs

MGD-MRK-1265, MGD-MRK-9898, MGD-MRK-9904

References

• Summaries
  All 33

  Phenotypes 9
• Earliest
  J:5684 Suzuki S, FV-4: a new gene affecting the splenomegaly induction by Friend leukemia virus. Jpn J Exp Med. 1975 Dec;45(6):473-8
• Latest
  J:132592 Ikeda H, et al., Virological properties and nucleotide sequences of Cas-E-type endogenous ecotropic murine leukemia viruses in South Asian wild mice, Mus musculus castaneus. J Virol. 2001 Jun;75(11):5049-58