Gabpb1 MGI Mouse Gene Detail - MGI:95611 - GA repeat binding protein, beta 1

Symbol

Gabpb1
Name

GA repeat binding protein, beta 1
Synonyms

BABPB2, E4TF1, E4TF1-47, E4TF1-53, E4Tf1B, GABPB1-1, GABPB1-2, NRF2B1, NRF2B2

Feature Type

protein coding gene
IDs

MGI:95611
NCBI Gene: 14391
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:126469362-126518257 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 61.76 cM
Mapping Data

4 experiments

SNPs within 2kb

904 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95611	protein coding gene	Chr2:126469362-126527184 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0026442	protein coding gene	Chr2:129850834-129902974 (-)
A/J	MGP_AJ_G0026405	protein coding gene	Chr2:124591095-124640300 (-)
AKR/J	MGP_AKRJ_G0026381	protein coding gene	Chr2:128160965-128209739 (-)
BALB/cJ	MGP_BALBcJ_G0026417	protein coding gene	Chr2:124858389-124907527 (-)
C3H/HeJ	MGP_C3HHeJ_G0026161	protein coding gene	Chr2:128651047-128702194 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0026863	protein coding gene	Chr2:133981998-134033115 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024240	protein coding gene	Chr2:119313759-119365349 (-)
CAST/EiJ	MGP_CASTEiJ_G0025622	protein coding gene	Chr2:128869819-128920013 (-)
CBA/J	MGP_CBAJ_G0026141	protein coding gene	Chr2:138889173-138941517 (-)
DBA/2J	MGP_DBA2J_G0026275	protein coding gene	Chr2:124002437-124051773 (-)
FVB/NJ	MGP_FVBNJ_G0026239	protein coding gene	Chr2:122660877-122709852 (-)
LP/J	MGP_LPJ_G0026380	protein coding gene	Chr2:130111786-130162665 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026259	protein coding gene	Chr2:142965237-143016991 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026918	protein coding gene	Chr2:128183223-128232071 (-)
PWK/PhJ	MGP_PWKPhJ_G0025358	protein coding gene	Chr2:123542988-123592631 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0025160	protein coding gene	Chr2:127256555-127313316 (-)
WSB/EiJ	MGP_WSBEiJ_G0025696	protein coding gene	Chr2:129064336-129116549 (-)

Human Ortholog

GABPB1, GA binding protein transcription factor subunit beta 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GABPB1, GA binding protein transcription factor subunit beta 1
Synonyms

BABPB2, E4TF1, E4TF1-47, E4TF1-53, E4TF1B, GABPB, GABPB-1, GABPB2, NRF2B1, NRF2B2
Links

HGNC:4074

NCBI Gene ID: 2553

neXtProt AC: NX_Q06547

UniProt: Q06547
Chr Location

15q21.2; chr15:50275389-50355408 (-) GRCh38

MGI Vertebrate Homology

Gabpb1 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: GABPB1
Protein SuperFamily

Integrin-linked_kinase
Gene Tree

Gabpb1

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Phenotype Summary

5 phenotypes from 2 alleles in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

52
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

45
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Gabpb1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

45 strains or lines available

Mice homozygous for a null allele exhibit embryonic lethality by E12.5.

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All GO Annotations

13
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

870
Tissues

100
cDNA Data

178
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gabpb1

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All Sequences

191
RefSeq

114
UniProt

12
CCDS

CCDS16685.1, CCDS16686.1, CCDS71135.1, CCDS71136.1, CCDS71137.1

Ensembl

ENSMUSG00000027361 (Evidence)
NCBI Gene

14391

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027361	Ensembl Gene Model \| MGI Sequence Detail	48896	C57BL/6J	± kb
transcript	ENSMUST00000110425	Ensembl \| MGI Sequence Detail	4153	Not Applicable
polypeptide	ENSMUSP00000106055	Ensembl \| MGI Sequence Detail	383	Not Applicable

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UniProt

12 Sequences
Protein Ontology

PR:000007764 GA-binding protein subunit beta-1

(term hierarchy)
PDB

1AWC
InterPro Domains

IPR002110 Ankyrin repeat

IPR050663 Ankyrin Repeat and SOCS Box

IPR036770 Ankyrin repeat-containing domain superfamily

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All nucleic 188

Genomic 1

cDNA 181

Primer pair 3

Other 3

Microarray probesets 8

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MGD-MRK-9920

Summaries

All 48

Developmental Gene Expression 9

Gene Ontology 5

Phenotypes 11
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:340390 Ihashi S, et al., Incomplete activation of Alyref and Gabpb1 leads to preimplantation arrest in cloned mouse embryos. Life Sci Alliance. 2023 Nov;6(11)

TSS for Gabpb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr26064	Chr2:126518031-126518060 (-)	211 bp
Tssr26063	Chr2:126517983-126518016 (-)	257 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24