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Gabra4 Gene Detail
Summary
  • Symbol
    Gabra4
  • Name
    gamma-aminobutyric acid type A receptor subunit alpha 4
  • Synonyms
    Gabra-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:95616
    NCBI Gene: 14397
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:71727092-71815651 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 38.08 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2358 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95616
 protein coding gene Chr5:71727077-71815651 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029608
 protein coding gene Chr5:71451591-71543717 (-)
A/J MGP_AJ_G0029576
 protein coding gene Chr5:68776730-68865715 (-)
AKR/J MGP_AKRJ_G0029524
 protein coding gene Chr5:70979986-71068790 (-)
BALB/cJ MGP_BALBcJ_G0029585
 protein coding gene Chr5:69454784-69549682 (-)
C3H/HeJ MGP_C3HHeJ_G0029308
 protein coding gene Chr5:71344454-71443890 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030039
 protein coding gene Chr5:74434581-74537529 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027279
 protein coding gene Chr5:64536499-64625388 (-)
CAST/EiJ MGP_CASTEiJ_G0028716
 protein coding gene Chr5:70474601-70561196 (-)
CBA/J MGP_CBAJ_G0029277
 protein coding gene Chr5:76809409-76913427 (-)
DBA/2J MGP_DBA2J_G0029423
 protein coding gene Chr5:68840091-68938542 (-)
FVB/NJ MGP_FVBNJ_G0029383
 protein coding gene Chr5:68023468-68114609 (-)
LP/J MGP_LPJ_G0029508
 protein coding gene Chr5:71913346-72021971 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029411
 protein coding gene Chr5:80180109-80283239 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030072
 protein coding gene Chr5:70569296-70667245 (-)
PWK/PhJ MGP_PWKPhJ_G0028440
 protein coding gene Chr5:67805143-67900689 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028274
 protein coding gene Chr5:69930527-70028484 (-)
WSB/EiJ MGP_WSBEiJ_G0028796
 protein coding gene Chr5:70821893-70910099 (-)



Homology
more
  • Human Ortholog
    GABRA4, gamma-aminobutyric acid type A receptor subunit alpha4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GABRA4, gamma-aminobutyric acid type A receptor subunit alpha4
  • Links
    NCBI Gene ID: 2557
    neXtProt AC: NX_P48169
    UniProt: P48169

  • Chr Location
    4p12; chr4:46918900-46993581 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GABRA4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    6
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    5
  • Genomic Mutations
    4 involving Gabra4
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    43 strains or lines available
Homozygous mutation of this gene does not appear to result in a phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    859
  • Tissues
    98
  • cDNA Data
    14
  • Literature Summary
    12
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029211 Ensembl Gene Model | MGI Sequence Detail 88560 C57BL/6J ±  kb
transcript ENSMUST00000199357 Ensembl | MGI Sequence Detail 2407 Not Applicable  
polypeptide ENSMUSP00000143675 Ensembl | MGI Sequence Detail 578 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000007769 gamma-aminobutyric acid receptor subunit alpha-4
    (term hierarchy)
  • InterPro Domains
    IPR005434 Gamma-aminobutyric-acid A receptor, alpha 4 subunit
    IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
    IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
    IPR047024 Gamma-aminobutyric acid receptor subunit alpha 1-6, transmembrane domain
    IPR038050 Neuronal acetylcholine receptor
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
  • GlyGen
    Q9D6F4 4 sites, 9 N-linked glycans (3 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 20
    cDNA 16
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-9925, MGD-MRK-9930
References
more
  • Summaries
    All 102
    Developmental Gene Expression 12
    Gene Ontology 10
    Phenotypes 43
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:350003 Zavalin K, et al., Region and layer-specific expression of GABA(A) receptor isoforms and KCC2 in developing cortex. Front Cell Neurosci. 2024;18:1390742
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory