About   Help   FAQ
Gabra6 Gene Detail
Summary
  • Symbol
    Gabra6
  • Name
    gamma-aminobutyric acid type A receptor subunit alpha 6
  • Synonyms
    alpha6, GABA-ARalpha6, Gabra-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:95618
    NCBI Gene: 14399
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:42197264-42211899 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 25.03 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    368 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95618
 protein coding gene Chr11:42197264-42211977 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018167
 protein coding gene Chr11:40997460-41017272 (-)
A/J MGP_AJ_G0018139
 protein coding gene Chr11:39447445-39461946 (-)
AKR/J MGP_AKRJ_G0018103
 protein coding gene Chr11:40604843-40619738 (-)
BALB/cJ MGP_BALBcJ_G0018108
 protein coding gene Chr11:39629776-39646138 (-)
C3H/HeJ MGP_C3HHeJ_G0017921
 protein coding gene Chr11:40637840-40652944 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018562
 protein coding gene Chr11:42281784-42298438 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016217
 protein coding gene Chr11:37591028-37605414 (-)
CAST/EiJ MGP_CASTEiJ_G0017485
 protein coding gene Chr11:40665408-40681395 (-)
CBA/J MGP_CBAJ_G0017894
 protein coding gene Chr11:44218664-44238311 (-)
DBA/2J MGP_DBA2J_G0018004
 protein coding gene Chr11:39230191-39245019 (-)
FVB/NJ MGP_FVBNJ_G0017998
 protein coding gene Chr11:38959301-38973827 (-)
LP/J MGP_LPJ_G0018076
 protein coding gene Chr11:41249042-41263559 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018022
 protein coding gene Chr11:45792868-45809213 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018601
 protein coding gene Chr11:40724906-40741132 (-)
PWK/PhJ MGP_PWKPhJ_G0017266
 protein coding gene Chr11:39246720-39261619 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017058
 protein coding gene Chr11:40495804-40510330 (-)
WSB/EiJ MGP_WSBEiJ_G0017534
 protein coding gene Chr11:40388439-40404161 (-)



Homology
more
  • Human Ortholog
    GABRA6, gamma-aminobutyric acid type A receptor subunit alpha6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GABRA6, gamma-aminobutyric acid type A receptor subunit alpha6
  • Links
    NCBI Gene ID: 2559
    neXtProt AC: NX_Q16445
    UniProt: Q16445

  • Chr Location
    5q34; chr5:161547063-161702593 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 3 alleles in 4 genetic backgrounds
    12 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile with normal cerebellar cytoarchitecture and normal responses to ethanol, pentobarbital and general anesthetics. Mice homozygous for a reporter allele are behaviorally normal and lack a cochlear phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    754
  • Tissues
    38
  • cDNA Data
    11
  • Literature Summary
    22
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020428 Ensembl Gene Model | MGI Sequence Detail 14636 C57BL/6J ±  kb
transcript ENSMUST00000155218 Ensembl | MGI Sequence Detail 2467 Not Applicable  
polypeptide ENSMUSP00000126114 Ensembl | MGI Sequence Detail 453 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007771 gamma-aminobutyric acid receptor subunit alpha-6
    (term hierarchy)
  • InterPro Domains
    IPR005436 Gamma-aminobutyric-acid A receptor, alpha 6 subunit
    IPR001390 Gamma-aminobutyric-acid A receptor, alpha subunit
    IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
    IPR047024 Gamma-aminobutyric acid receptor subunit alpha 1-6, transmembrane domain
    IPR038050 Neuronal acetylcholine receptor
    IPR006201 Neurotransmitter-gated ion-channel
    IPR018000 Neurotransmitter-gated ion-channel, conserved site
    IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
    IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
    IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
    IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
  • GlyGen
    P16305 3 sites, 3 N-linked glycans (3 sites)
Molecular
Reagents
less
  • All nucleic 13
    cDNA 11
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-9926, MGD-MRK-9932
References
more
  • Summaries
    All 128
    Developmental Gene Expression 22
    Gene Ontology 9
    Phenotypes 44
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:349871 Broersen R, et al., Synaptic mechanisms for associative learning in the cerebellar nuclei. Nat Commun. 2023 Nov 20;14(1):7459
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory