Slc6a13 MGI Mouse Gene Detail - MGI:95629 - solute carrier family 6 (neurotransmitter transporter, GABA), member 13

Symbol

Slc6a13
Name

solute carrier family 6 (neurotransmitter transporter, GABA), member 13
Synonyms

Gabt3, Gat2

Feature Type

protein coding gene
IDs

MGI:95629
NCBI Gene: 14412
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:121277247-121314680 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 57.22 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

1100 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95629	protein coding gene	Chr6:121277186-121314692 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031216	protein coding gene	Chr6:124245007-124283122 (+)
A/J	MGP_AJ_G0031185	protein coding gene	Chr6:119455254-119493097 (+)
AKR/J	MGP_AKRJ_G0031116	protein coding gene	Chr6:122680495-122718585 (+)
BALB/cJ	MGP_BALBcJ_G0031196	protein coding gene	Chr6:119223296-119261088 (+)
C3H/HeJ	MGP_C3HHeJ_G0030914	protein coding gene	Chr6:122708094-122747137 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031654	protein coding gene	Chr6:127417230-127454795 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028814	protein coding gene	Chr6:116361856-116399461 (+)
CAST/EiJ	MGP_CASTEiJ_G0030303	protein coding gene	Chr6:123159662-123198767 (+)
CBA/J	MGP_CBAJ_G0030879	protein coding gene	Chr6:132480220-132524224 (+)
DBA/2J	MGP_DBA2J_G0031035	protein coding gene	Chr6:118346133-118383700 (+)
FVB/NJ	MGP_FVBNJ_G0030987	protein coding gene	Chr6:117490917-117530303 (+)
LP/J	MGP_LPJ_G0031114	protein coding gene	Chr6:124234725-124272710 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031021	protein coding gene	Chr6:136418856-136460603 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031683	protein coding gene	Chr6:122718620-122757949 (+)
PWK/PhJ	MGP_PWKPhJ_G0030018	protein coding gene	Chr6:117388749-117426949 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029847	protein coding gene	Chr6:121453281-121492877 (+)
WSB/EiJ	MGP_WSBEiJ_G0030386	protein coding gene	Chr6:123009438-123052213 (+)

Human Ortholog

SLC6A13, solute carrier family 6 member 13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SLC6A13, solute carrier family 6 member 13
Synonyms

GAT-2, GAT2, GAT3
Links

HGNC:11046

NCBI Gene ID: 6540

neXtProt AC: NX_Q9NSD5

UniProt: Q9NSD5
Chr Location

12p13.33; chr12:220621-262873 (-) GRCh38

MGI Vertebrate Homology

Slc6a13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SLC6A13
Gene Tree

Slc6a13

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

1
Targeted

8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

47 strains or lines available

Mice homozygous for a knock-out allele exhibit reduced taurine levels in the liver and increased taurine levels in the brain.

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All GO Annotations

37
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1123
Tissues

294
cDNA Data

48
Literature Summary

14

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase slc6a13

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All Sequences

58
RefSeq

17
UniProt

5
CCDS

CCDS20490.1

Ensembl

ENSMUSG00000030108 (Evidence)
NCBI Gene

14412

			Length	Strain/Species	Flank
genomic	14412	NCBI Gene Model \| MGI Sequence Detail	37434	C57BL/6J	± kb
transcript	NM_001379107	RefSeq \| MGI Sequence Detail	2293	C57BL/6
polypeptide	P31649	UniProt \| EBI \| MGI Sequence Detail	602	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000015179 sodium- and chloride-dependent GABA transporter 2

(term hierarchy)
InterPro Domains

IPR000175 Sodium:neurotransmitter symporter

IPR002981 Sodium:neurotransmitter symporter, GABA, GAT-2

IPR037272 Sodium:neurotransmitter symporter superfamily
GlyGen

P31649 4 sites

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All nucleic 51

cDNA 48

Primer pair 3

Microarray probesets 3

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MGD-MRK-9949

Summaries

All 51

Developmental Gene Expression 14

Gene Ontology 8

Phenotypes 6
Earliest

J:3704 Liu QR, et al., Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected] [published erratum appers in J Biol Chem 1993 Apr 25;268(12):9156]. J Biol Chem. 1993 Jan 25;268(3):2106-12
Latest

J:345075 Wang XW, et al., Histone methyltransferase Ezh2 coordinates mammalian axon regeneration via regulation of key regenerative pathways. J Clin Invest. 2024 Feb 1;134(3)

TSS for Slc6a13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58590	Chr6:121277239-121277256 (+)	1 bp
Tssr58591	Chr6:121277691-121277714 (+)	456 bp
Tssr58592	Chr6:121295197-121295215 (+)	17,959 bp
Tssr58593	Chr6:121313342-121313367 (+)	36,108 bp
Tssr58594	Chr6:121313759-121313809 (+)	36,537 bp
Tssr58595	Chr6:121313820-121313831 (+)	36,579 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24