Gas1 MGI Mouse Gene Detail - MGI:95655 - growth arrest specific 1

Symbol

Gas1
Name

growth arrest specific 1
Synonyms

Gas-1

Feature Type

protein coding gene
IDs

MGI:95655
NCBI Gene: 14451
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr13:60322219-60325179 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 31.92 cM, cytoband B3-C2
Mapping Data

10 experiments

SNPs within 2kb

99 from dbSNP Build 142
Strain Annotations

18
RFLP

3

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95655	protein coding gene	Chr13:60322219-60325179 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020646	protein coding gene	Chr13:59913595-59916556 (-)
A/J	MGP_AJ_G0020601	protein coding gene	Chr13:57678830-57681793 (-)
AKR/J	MGP_AKRJ_G0020577	protein coding gene	Chr13:59405557-59408519 (-)
BALB/cJ	MGP_BALBcJ_G0020597	protein coding gene	Chr13:57937191-57940154 (-)
C3H/HeJ	MGP_C3HHeJ_G0020394	protein coding gene	Chr13:59191032-59193993 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021031	protein coding gene	Chr13:61727761-61730721 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018613	protein coding gene	Chr13:55560722-55563679 (-)
CAST/EiJ	MGP_CASTEiJ_G0019910	protein coding gene	Chr13:59398245-59401211 (-)
CBA/J	MGP_CBAJ_G0020354	protein coding gene	Chr13:64050382-64053343 (-)
DBA/2J	MGP_DBA2J_G0020478	protein coding gene	Chr13:57210700-57213661 (-)
FVB/NJ	MGP_FVBNJ_G0020456	protein coding gene	Chr13:56707209-56710781 (-)
LP/J	MGP_LPJ_G0020554	protein coding gene	Chr13:60181434-60184397 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020486	protein coding gene	Chr13:63333444-63336408 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021074	protein coding gene	Chr13:59005008-59007969 (-)
PWK/PhJ	MGP_PWKPhJ_G0019665	protein coding gene	Chr13:57257357-57260318 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019492	protein coding gene	Chr13:57902300-57905262 (-)
WSB/EiJ	MGP_WSBEiJ_G0019972	protein coding gene	Chr13:59459852-59462812 (-)

Human Ortholog

GAS1, growth arrest specific 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GAS1, growth arrest specific 1
Links

HGNC:4165

NCBI Gene ID: 2619

neXtProt AC: NX_P54826

UniProt: P54826
Chr Location

9q21.33; chr9:86944362-86947506 (-) GRCh38

MGI Vertebrate Homology

Gas1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GAS1
Gene Tree

Gas1

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Phenotype Summary

87 phenotypes from 2 alleles in 4 genetic backgrounds
66 phenotypes from multigenic genotypes
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

4
Genomic Mutations

1 involving Gas1
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for disruption of this gene experience background sensitive reduction of viability. Developmental defects are found in the eyes, cerebellum and limbs.

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All GO Annotations

64
GO References

21

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1311
Tissues

446
cDNA Data

78
Literature Summary

60

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gas1

ZFIN gas1a

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All Sequences

39
RefSeq

2
UniProt

3
CCDS

CCDS26579.1

Ensembl

ENSMUSG00000052957 (Evidence)
NCBI Gene

14451

			Length	Strain/Species	Flank
genomic	14451	NCBI Gene Model \| MGI Sequence Detail	2961	C57BL/6J	± kb
transcript	NM_008086	RefSeq \| MGI Sequence Detail	2961	ZRU/MplStud
polypeptide	Q01721	UniProt \| EBI \| MGI Sequence Detail	343	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007848 growth arrest-specific protein 1

(term hierarchy)
InterPro Domains

IPR016017 GDNF/GAS1

IPR039596 Growth arrest-specific protein 1
GlyGen

Q01721 2 sites, 1 N-linked glycan (1 site)

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All nucleic 90

Genomic 1

cDNA 78

Primer pair 4

Other 7

Microarray probesets 5

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MGD-MRK-9985, MGD-MRK-9992, MGI:2145453

Summaries

All 117

Developmental Gene Expression 60

Gene Ontology 21

Phenotypes 33
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:351872 Kumari A, et al., Distinct expression patterns of Hedgehog signaling components in mouse gustatory system during postnatal tongue development and adult homeostasis. PLoS One. 2024;19(6):e0294835

TSS for Gas1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr122906	Chr13:60325312-60325388 (-)	-171 bp
Tssr122905	Chr13:60325206-60325213 (-)	-31 bp
Tssr122904	Chr13:60325171-60325187 (-)	0 bp
Tssr122903	Chr13:60324980-60325016 (-)	181 bp
Tssr122902	Chr13:60324932-60324962 (-)	232 bp
Tssr122901	Chr13:60324878-60324897 (-)	291 bp
Tssr122900	Chr13:60324361-60324378 (-)	809 bp
Tssr122899	Chr13:60323863-60323867 (-)	1,314 bp
Tssr122898	Chr13:60323020-60323038 (-)	2,150 bp
Tssr122897	Chr13:60322838-60322852 (-)	2,334 bp
Tssr122896	Chr13:60322801-60322811 (-)	2,373 bp
Tssr122895	Chr13:60322683-60322702 (-)	2,486 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24