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Gata2 Gene Detail
Summary
  • Symbol
    Gata2
  • Name
    GATA binding protein 2
  • Synonyms
    Gata-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95662
    NCBI Gene: 14461
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr6:88170873-88184014 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 39.20 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    187 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95662
 protein coding gene Chr6:88170873-88184014 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031007
 protein coding gene Chr6:89578982-89594141 (+)
A/J MGP_AJ_G0030973
 protein coding gene Chr6:86127541-86140790 (+)
AKR/J MGP_AKRJ_G0030904
 protein coding gene Chr6:88615001-88628141 (+)
BALB/cJ MGP_BALBcJ_G0030986
 protein coding gene Chr6:86125738-86138876 (+)
C3H/HeJ MGP_C3HHeJ_G0030724
 protein coding gene Chr6:95832739-95847048 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031443
 protein coding gene Chr6:91972700-91988142 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028625
 protein coding gene Chr6:84297524-84306225 (+)
CAST/EiJ MGP_CASTEiJ_G0030095
 protein coding gene Chr6:88702864-88715999 (+)
CBA/J MGP_CBAJ_G0030670
 protein coding gene Chr6:95540986-95554170 (+)
DBA/2J MGP_DBA2J_G0030826
 protein coding gene Chr6:85422075-85435220 (+)
FVB/NJ MGP_FVBNJ_G0030779
 protein coding gene Chr6:84612756-84626619 (+)
LP/J MGP_LPJ_G0030903
 protein coding gene Chr6:89614367-89628247 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030812
 protein coding gene Chr6:99652961-99667075 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031470
 protein coding gene Chr6:88464754-88477891 (+)
PWK/PhJ MGP_PWKPhJ_G0029810
 protein coding gene Chr6:84393654-84406823 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029638
 protein coding gene Chr6:87278585-87291733 (+)
WSB/EiJ MGP_WSBEiJ_G0030176
 protein coding gene Chr6:88918448-88932780 (+)



Homology
more
  • Human Ortholog
    GATA2, GATA binding protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GATA2, GATA binding protein 2
  • Synonyms
    DCML, IMD21, MONOMAC, NFE1B
  • Links
    NCBI Gene ID: 2624
    neXtProt AC: NX_P23769
    UniProt: P23769

  • Chr Location
    3q21.3; chr3:128479422-128493201 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human GATA2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 12 alleles in 11 genetic backgrounds
    4 phenotypes from multigenic genotypes
    103 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants show reduced placental secretion of angiogenic factors, hematopoietic defects, enlarged pericardial sacs, reduced numbers of V2-expressing interneurons of ventral spinal cord, and die by embryonic day 11.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    121
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1794
  • Tissues
    585
  • cDNA Data
    24
  • Literature Summary
    209
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14461 NCBI Gene Model | MGI Sequence Detail 13142 C57BL/6J ±  kb
    transcript NM_008090 RefSeq | MGI Sequence Detail 3258 ZRU/MplStud  
    polypeptide O09100 UniProt | EBI | MGI Sequence Detail 480 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      Genomic 6
      cDNA 28
      Primer pair 21
      Other 8

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10003, MGD-MRK-9999
    References
    more
    • Summaries
      All 378
      Developmental Gene Expression 209
      Gene Ontology 35
      Phenotypes 103
    • Earliest
      J:699 Zon LI, et al., GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem. 1991 Dec 5;266(34):22948-53
    • Latest
      J:357469 Sivori M, et al., The pelvic organs receive no parasympathetic innervation. Elife. 2024;15
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory