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Gata3 Gene Detail
Summary
  • Symbol
    Gata3
  • Name
    GATA binding protein 3
  • Synonyms
    Gata-3, jal
  • Feature Type
    protein coding gene
  • IDs
    MGI:95663
    NCBI Gene: 14462
  • Alliance
    gene page
  • Transcription Start Sites
    27 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:9861889-9894845 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 6.69 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    813 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95663
 protein coding gene Chr2:9861889-9894845 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025333
 protein coding gene Chr2:7190687-7226840 (-)
A/J MGP_AJ_G0025310
 protein coding gene Chr2:6869096-6903015 (-)
AKR/J MGP_AKRJ_G0025279
 protein coding gene Chr2:7084390-7118820 (-)
BALB/cJ MGP_BALBcJ_G0025306
 protein coding gene Chr2:6871832-6905455 (-)
C3H/HeJ MGP_C3HHeJ_G0025066
 protein coding gene Chr2:7042168-7075257 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025748
 protein coding gene Chr2:7384694-7421945 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023162
 protein coding gene Chr2:6381660-6414305 (-)
CAST/EiJ MGP_CASTEiJ_G0024529
 protein coding gene Chr2:7062562-7096805 (-)
CBA/J MGP_CBAJ_G0025045
 protein coding gene Chr2:7668863-7710117 (-)
DBA/2J MGP_DBA2J_G0025177
 protein coding gene Chr2:6796470-6835451 (-)
FVB/NJ MGP_FVBNJ_G0025139
 protein coding gene Chr2:6741934-6777201 (-)
LP/J MGP_LPJ_G0025263
 protein coding gene Chr2:7064601-7100449 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025171
 protein coding gene Chr2:7675014-7710154 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025806
 protein coding gene Chr2:7036893-7073255 (-)
PWK/PhJ MGP_PWKPhJ_G0024280
 protein coding gene Chr2:6783932-6817977 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024080
 protein coding gene Chr2:7026149-7060206 (-)
WSB/EiJ MGP_WSBEiJ_G0024599
 protein coding gene Chr2:7136899-7170210 (-)



Homology
more
  • Human Ortholog
    GATA3, GATA binding protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GATA3, GATA binding protein 3
  • Synonyms
    HDR, HDRS
  • Links
    NCBI Gene ID: 2625
    neXtProt AC: NX_P23771
    UniProt: P23771

  • Chr Location
    10p14; chr10:8045333-8075198 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gata3 mouse models; 4 with human GATA3 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    185 phenotypes from 13 alleles in 23 genetic backgrounds
    10 phenotypes from multigenic genotypes
    181 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene causes embryonic lethality and a variety of embryonic defects. Homozygotes for a spontaneous allele show partial hair loss and defects in hair structure and hair growth cycle regulation. Homozygotes for a null allele show severe cardiac outflow tract defects, such as ventricular septal defect, double outlet right ventricle, aortic arch anomalies and persistent truncus arteriosus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    224
  • GO References
    75
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1781
  • Tissues
    539
  • cDNA Data
    85
  • Literature Summary
    313
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14462 NCBI Gene Model | MGI Sequence Detail 32957 C57BL/6J ±  kb
    transcript NM_001417046 RefSeq | MGI Sequence Detail 3321 ZRU/MplStud  
    polypeptide P23772 UniProt | EBI | MGI Sequence Detail 443 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 130
      Genomic 6
      cDNA 89
      Primer pair 16
      Other 19

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10000, MGD-MRK-10004, MGI:2181648
    References
    more
    • Summaries
      All 572
      Developmental Gene Expression 313
      Diseases 2
      Gene Ontology 75
      Phenotypes 181
    • Earliest
      J:699 Zon LI, et al., GATA-binding transcription factors in mast cells regulate the promoter of the mast cell carboxypeptidase A gene. J Biol Chem. 1991 Dec 5;266(34):22948-53
    • Latest
      J:357469 Sivori M, et al., The pelvic organs receive no parasympathetic innervation. Elife. 2024;15
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory