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Gbx2 Gene Detail
Summary
  • Symbol
    Gbx2
  • Name
    gastrulation brain homeobox 2
  • Synonyms
    Gbx-2, MMoxA, Stra7
  • Feature Type
    protein coding gene
  • IDs
    MGI:95668
    NCBI Gene: 14472
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr1:89855684-89858898 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 45.06 cM, cytoband C5-E1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95668
 protein coding gene Chr1:89855678-89858901 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016291
 protein coding gene Chr1:91393528-91396751 (-)
A/J MGP_AJ_G0016272
 protein coding gene Chr1:88126227-88129438 (-)
AKR/J MGP_AKRJ_G0016233
 protein coding gene Chr1:90726681-90729894 (-)
BALB/cJ MGP_BALBcJ_G0016228
 protein coding gene Chr1:88284540-88287743 (-)
C3H/HeJ MGP_C3HHeJ_G0016057
 protein coding gene Chr1:90943368-90946575 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016687
 protein coding gene Chr1:94929916-94933127 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014405
 protein coding gene Chr1:82406014-82409187 (-)
CAST/EiJ MGP_CASTEiJ_G0015642
 protein coding gene Chr1:90267758-90270973 (-)
CBA/J MGP_CBAJ_G0016033
 protein coding gene Chr1:97977100-97980307 (-)
DBA/2J MGP_DBA2J_G0016136
 protein coding gene Chr1:87353217-87356426 (-)
FVB/NJ MGP_FVBNJ_G0016135
 protein coding gene Chr1:86369786-86373321 (-)
LP/J MGP_LPJ_G0016207
 protein coding gene Chr1:92527601-92530824 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016160
 protein coding gene Chr1:101250219-101253430 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016727
 protein coding gene Chr1:90754360-90757575 (-)
PWK/PhJ MGP_PWKPhJ_G0015426
 protein coding gene Chr1:86745698-86748981 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015209
 protein coding gene Chr1:89654396-89658986 (-)
WSB/EiJ MGP_WSBEiJ_G0015700
 protein coding gene Chr1:90485640-90488853 (-)



Homology
more
  • Human Ortholog
    GBX2, gastrulation brain homeobox 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GBX2, gastrulation brain homeobox 2
  • Links
    NCBI Gene ID: 2637
    neXtProt AC: NX_P52951
    UniProt: P52951

  • Chr Location
    2q37.2; chr2:236161340-236168386 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    75 phenotypes from 5 alleles in 9 genetic backgrounds
    28 phenotypes from multigenic genotypes
    73 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality associated with vascular, neurological, skeletal, and craniofacial defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1470
  • Tissues
    350
  • cDNA Data
    26
  • Literature Summary
    245
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14472 NCBI Gene Model | MGI Sequence Detail 3215 C57BL/6J ±  kb
    transcript NM_010262 RefSeq | MGI Sequence Detail 2126 ZRU/MplStud  
    polypeptide P48031 UniProt | EBI | MGI Sequence Detail 348 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 5
      cDNA 30
      Primer pair 9
      Other 30

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10011, MGD-MRK-10013, MGD-MRK-36498, MGI:107918
    References
    more
    • Summaries
      All 322
      Developmental Gene Expression 245
      Gene Ontology 10
      Phenotypes 73
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:346138 Assali A, et al., EphB1 controls long-range cortical axon guidance through a cell non-autonomous role in GABAergic cells. Development. 2024 Mar 1;151(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory