Gc MGI Mouse Gene Detail - MGI:95669 - vitamin D binding protein

Symbol

Gc
Name

vitamin D binding protein
Synonyms

DBP, vitamin D binding protein

Feature Type

protein coding gene
IDs

MGI:95669
NCBI Gene: 14473
Alliance

gene page
Transcription Start Sites

23 TSS

Sequence Map

Chr5:89565381-89605757 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 44.32 cM
Mapping Data

6 experiments

SNPs within 2kb

1175 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95669	protein coding gene	Chr5:89565370-89605757 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029715	protein coding gene	Chr5:90431331-90469159 (-)
A/J	MGP_AJ_G0029681	protein coding gene	Chr5:86878006-86912415 (-)
AKR/J	MGP_AKRJ_G0029627	protein coding gene	Chr5:89733271-89768348 (-)
BALB/cJ	MGP_BALBcJ_G0029691	protein coding gene	Chr5:87781757-87816994 (-)
C3H/HeJ	MGP_C3HHeJ_G0029414	protein coding gene	Chr5:90077262-90116223 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0030145	protein coding gene	Chr5:94106828-94140128 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027381	protein coding gene	Chr5:82648304-82685004 (-)
CAST/EiJ	MGP_CASTEiJ_G0028824	protein coding gene	Chr5:89489160-89523070 (-)
CBA/J	MGP_CBAJ_G0029383	protein coding gene	Chr5:97262900-97302986 (-)
DBA/2J	MGP_DBA2J_G0029528	protein coding gene	Chr5:86943618-86976851 (-)
FVB/NJ	MGP_FVBNJ_G0029487	protein coding gene	Chr5:85848847-85890029 (-)
LP/J	MGP_LPJ_G0029616	protein coding gene	Chr5:90834924-90869834 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029516	protein coding gene	Chr5:102278996-102321373 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0030179	protein coding gene	Chr5:89250316-89288227 (-)
PWK/PhJ	MGP_PWKPhJ_G0028543	protein coding gene	Chr5:86003266-86037939 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0028378	protein coding gene	Chr5:88655735-88686394 (-)
WSB/EiJ	MGP_WSBEiJ_G0028903	protein coding gene	Chr5:89659892-89699903 (-)

Human Ortholog

GC, GC vitamin D binding protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GC, GC vitamin D binding protein
Synonyms

DBP, DBP/GC, DBP-maf, Gc-MAF, GcMAF, GRD3, HEL-S-51, VDB, VDBG, VDBP
Links

HGNC:4187

NCBI Gene ID: 2638

neXtProt AC: NX_P02774

UniProt: P02774
Chr Location

4q13.3; chr4:71741693-71805520 (-) GRCh38

MGI Vertebrate Homology

Gc stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GC
Gene Tree

Gc

Diseases

11 with human GC associations

				Human Disease	Mouse Models
				arthritis IDs arthritis DOID:848 ICD10CM:M19.90 MESH:D001168 NCI:C2883 UMLS_CUI:C0003864
				chronic obstructive pulmonary disease IDs chronic obstructive pulmonary disease DOID:3083 DOID:11500 DOID:6144 EFO:0000341 ICD10CM:J44.9 MESH:D029424 NCI:C3199 OMIM:606963 UMLS_CUI:C0024117
				Crohn's disease IDs Crohn's disease DOID:8778 DOID:8784 DOID:8855 DOID:8942 EFO:0000384 ICD10CM:K50.1 ICD9CM:555.1 MESH:D003424 NCI:C37262 UMLS_CUI:C0156147
				Graves' disease IDs Graves' disease DOID:12361 EFO:0004237 ICD10CM:E05.0 MESH:D006111 NCI:C3071 OMIM:275000 UMLS_CUI:C0018213
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				human immunodeficiency virus infectious disease IDs human immunodeficiency virus infectious disease DOID:526 ICD10CM:B20 ICD9CM:042 ICD9CM:042-042.99 MESH:D015658 NCI:C3108 UMLS_CUI:C0019693
				multiple sclerosis IDs multiple sclerosis DOID:2377 ICD10CM:G35 ICD9CM:340 MESH:D009103 NCI:C3243 OMIM:612594 OMIM:612595 OMIM:612596 UMLS_CUI:C0026769
				rheumatic fever IDs rheumatic fever DOID:1586 DOID:1006 DOID:1007 ICD10CM:I00 ICD10CM:I00-I02 ICD9CM_2006:390-392.99 ICD9CM:390 ICD9CM:390-392.99 MESH:D012213 NCI:C34984 UMLS_CUI:C0035436 UMLS_CUI:C0264743
				type 1 diabetes mellitus IDs type 1 diabetes mellitus DOID:9744 ICD10CM:E10 KEGG:04940 MESH:D003922 NCI:C2986 OMIM:222100 UMLS_CUI:C0011854
				ulcerative colitis IDs ulcerative colitis DOID:8577 DOID:8576 DOID:9016 EFO:0000729 ICD10CM:K51 ICD9CM:556 ICD9CM:556.5 ICD9CM:556.9 MESH:D003093 NCI:C2952 UMLS_CUI:C0009324 UMLS_CUI:C0375359
				uveitis IDs uveitis DOID:13141 ICD10CM:H20.9 MESH:D014605 NCI:C26909 UMLS_CUI:C0042164

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Endonuclease-mediated

3
Radiation induced

1
Spontaneous

1
Targeted

5
Genomic Mutations

4 involving Gc
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruption of this gene show an essentially normal phenotype. However, they have an increased sensitivity to vitamin D deficiency in the diet.

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All GO Annotations

15
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

743
Tissues

16
cDNA Data

190
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gc

ZFIN gc

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS19407.1

Ensembl

ENSMUSG00000035540 (Evidence)
NCBI Gene

14473

			Length	Strain/Species	Flank
genomic	ENSMUSG00000035540	Ensembl Gene Model \| MGI Sequence Detail	40377	C57BL/6J	± kb
transcript	ENSMUST00000049209	Ensembl \| MGI Sequence Detail	1801	Not Applicable
polypeptide	ENSMUSP00000046636	Ensembl \| MGI Sequence Detail	476	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007883 vitamin D-binding protein

(term hierarchy)
InterPro Domains

IPR000264 ALB/AFP/VDB

IPR020857 Serum albumin, conserved site

IPR020858 Serum albumin-like

IPR014760 Serum albumin, N-terminal

IPR000213 Vitamin D-binding protein

IPR015247 Vitamin D binding protein, domain III
GlyGen

P21614 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 197

Genomic 2

cDNA 192

Primer pair 3

Microarray probesets 3

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MGD-MRK-10014

Summaries

All 63

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 26
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr51725	Chr5:89605622-89605643 (-)	124 bp
Tssr51724	Chr5:89593253-89593291 (-)	12,485 bp
Tssr51723	Chr5:89593230-89593248 (-)	12,518 bp
Tssr51722	Chr5:89593205-89593225 (-)	12,542 bp
Tssr51721	Chr5:89593176-89593187 (-)	12,575 bp
Tssr51720	Chr5:89591418-89591442 (-)	14,327 bp
Tssr51719	Chr5:89591373-89591394 (-)	14,373 bp
Tssr51718	Chr5:89591332-89591352 (-)	14,415 bp
Tssr51717	Chr5:89589740-89589751 (-)	16,011 bp
Tssr51716	Chr5:89589530-89589550 (-)	16,217 bp
Tssr51715	Chr5:89589511-89589529 (-)	16,237 bp
Tssr51714	Chr5:89589494-89589506 (-)	16,257 bp
Tssr51713	Chr5:89589473-89589491 (-)	16,275 bp
Tssr51712	Chr5:89589454-89589472 (-)	16,294 bp
Tssr51711	Chr5:89589122-89589162 (-)	16,615 bp
Tssr51710	Chr5:89587467-89587505 (-)	18,271 bp
Tssr51709	Chr5:89586301-89586314 (-)	19,449 bp
Tssr51708	Chr5:89586124-89586133 (-)	19,628 bp
Tssr51707	Chr5:89583469-89583507 (-)	22,269 bp
Tssr51706	Chr5:89583436-89583447 (-)	22,315 bp
Tssr51705	Chr5:89582881-89582916 (-)	22,858 bp
Tssr51704	Chr5:89582483-89582517 (-)	23,257 bp
Tssr51703	Chr5:89566908-89566912 (-)	38,847 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24