Gpd1 MGI Mouse Gene Detail - MGI:95679 - glycerol-3-phosphate dehydrogenase 1 (soluble)

Symbol

Gpd1
Name

glycerol-3-phosphate dehydrogenase 1 (soluble)
Synonyms

Gdc-1, Gdc1

Feature Type

protein coding gene
IDs

MGI:95679
NCBI Gene: 14555
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:99615468-99622895 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 56.13 cM, cytoband F1-F3
Mapping Data

72 experiments

SNPs within 2kb

252 from dbSNP Build 142
Strain Annotations

18
PCR

4
RFLP

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95679	protein coding gene	Chr15:99615396-99622895 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022341	protein coding gene	Chr15:101594340-101601829 (+)
A/J	MGP_AJ_G0022299	protein coding gene	Chr15:97533403-97540887 (+)
AKR/J	MGP_AKRJ_G0022275	protein coding gene	Chr15:100538423-100545911 (+)
BALB/cJ	MGP_BALBcJ_G0022305	protein coding gene	Chr15:97718644-97726088 (+)
C3H/HeJ	MGP_C3HHeJ_G0022073	protein coding gene	Chr15:100605492-100612976 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022750	protein coding gene	Chr15:105376374-105383977 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020276	protein coding gene	Chr15:93426057-93433949 (+)
CAST/EiJ	MGP_CASTEiJ_G0021597	protein coding gene	Chr15:101474478-101481826 (+)
CBA/J	MGP_CBAJ_G0022042	protein coding gene	Chr15:108968553-108975997 (+)
DBA/2J	MGP_DBA2J_G0022169	protein coding gene	Chr15:96972002-96979492 (+)
FVB/NJ	MGP_FVBNJ_G0022149	protein coding gene	Chr15:95963264-95970759 (+)
LP/J	MGP_LPJ_G0022240	protein coding gene	Chr15:101738659-101746380 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022169	protein coding gene	Chr15:112851712-112859156 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022765	protein coding gene	Chr15:100654040-100661530 (+)
PWK/PhJ	MGP_PWKPhJ_G0021336	protein coding gene	Chr15:97114880-97122368 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021171	protein coding gene	Chr15:100496918-100504483 (+)
WSB/EiJ	MGP_WSBEiJ_G0021648	protein coding gene	Chr15:101169839-101177329 (+)

Human Ortholog

GPD1, glycerol-3-phosphate dehydrogenase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPD1, glycerol-3-phosphate dehydrogenase 1
Synonyms

GPD-C, GPDH-C, HTGTI
Links

HGNC:4455

NCBI Gene ID: 2819

neXtProt AC: NX_P21695

UniProt: P21695
Chr Location

12q13.12; chr12:50103982-50111313 (+) GRCh38

MGI Vertebrate Homology

Gpd1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GPD1
Protein SuperFamily

Glycerol-3-P_dh
Gene Tree

Gpd1

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References

1 with disease annotations

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Phenotype Summary

9 phenotypes from 3 alleles in 3 genetic backgrounds
32 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

2
Radiation induced

2
Spontaneous

1
Targeted

2
Genomic Mutations

3 involving Gpd1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a spontaneous mutation are viable and phenotypically normal but show loss of glycerol-3-phosphate dehydrogenase 1 activity in adult tissues.

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All GO Annotations

28
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1111
Tissues

340
cDNA Data

178
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GPD1L2

Xenbase gpd1

ZFIN gpd1b

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All Sequences

40
RefSeq

2
UniProt

2
CCDS

CCDS27828.1

Ensembl

ENSMUSG00000023019 (Evidence)
NCBI Gene

14555

			Length	Strain/Species	Flank
genomic	14555	NCBI Gene Model \| MGI Sequence Detail	7428	C57BL/6J	± kb
transcript	NM_010271	RefSeq \| MGI Sequence Detail	2798	ZRU/MplStud
polypeptide	P13707	UniProt \| EBI \| MGI Sequence Detail	349	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008169 glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

(term hierarchy)
EC

1.1.1.8
InterPro Domains

IPR013328 6-phosphogluconate dehydrogenase, domain 2

IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily

IPR006168 Glycerol-3-phosphate dehydrogenase, NAD-dependent

IPR006109 Glycerol-3-phosphate dehydrogenase, NAD-dependent, C-terminal

IPR017751 Glycerol-3-phosphate dehydrogenase, NAD-dependent, eukaryotic

IPR011128 Glycerol-3-phosphate dehydrogenase, NAD-dependent, N-terminal

IPR036291 NAD(P)-binding domain superfamily
GlyGen

P13707 1 site, 1 O-linked glycan (1 site)

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All nucleic 196

Genomic 12

cDNA 180

Primer pair 2

Other 2

Microarray probesets 6

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MGD-MRK-10025, MGD-MRK-10027, MGI:2146056

Summaries

All 127

Developmental Gene Expression 7

Diseases 1

Gene Ontology 14

Phenotypes 32
Earliest

J:5309 Kozak LP, Genetic control of -glycerolphosphate dehydrogenase in mouse brain. Proc Natl Acad Sci U S A. 1972 Nov;69(11):3170-4
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gpd1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr133059	Chr15:99615459-99615475 (+)	-1 bp
Tssr133060	Chr15:99616843-99616846 (+)	1,377 bp
Tssr133061	Chr15:99617004-99617019 (+)	1,544 bp
Tssr133062	Chr15:99617021-99617045 (+)	1,565 bp
Tssr133063	Chr15:99621306-99621323 (+)	5,847 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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