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B4galt1 Gene Detail
Summary
  • Symbol
    B4galt1
  • Name
    UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
  • Synonyms
    b1,4-Galactosyltransferase I, B-1,4-GalT1, beta 1,4-Galactosyltransferase I, beta-1,4-GalT1, GalT, Ggtb, Ggtb2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95705
    NCBI Gene: 14595
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:40804602-40854005 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 20.46 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1230 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95705
 protein coding gene Chr4:40804602-40855711 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028148
 protein coding gene Chr4:38709940-38760295 (-)
A/J MGP_AJ_G0028106
 protein coding gene Chr4:37249739-37298736 (-)
AKR/J MGP_AKRJ_G0028069
 protein coding gene Chr4:38196555-38250856 (-)
BALB/cJ MGP_BALBcJ_G0028118
 protein coding gene Chr4:37574102-37624420 (-)
C3H/HeJ MGP_C3HHeJ_G0027846
 protein coding gene Chr4:38736239-38787991 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028559
 protein coding gene Chr4:40143061-40192945 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025900
 protein coding gene Chr4:34901447-34948670 (-)
CAST/EiJ MGP_CASTEiJ_G0027302
 protein coding gene Chr4:38394714-38446147 (-)
CBA/J MGP_CBAJ_G0027818
 protein coding gene Chr4:41502848-41558543 (-)
DBA/2J MGP_DBA2J_G0027962
 protein coding gene Chr4:37167053-37216159 (-)
FVB/NJ MGP_FVBNJ_G0027929
 protein coding gene Chr4:36502171-36552099 (-)
LP/J MGP_LPJ_G0028070
 protein coding gene Chr4:38774603-38826730 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027962
 protein coding gene Chr4:44842260-44893366 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028618
 protein coding gene Chr4:38307528-38361483 (-)
PWK/PhJ MGP_PWKPhJ_G0027021
 protein coding gene Chr4:37163805-37214766 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026848
 protein coding gene Chr4:38005781-38056538 (-)
WSB/EiJ MGP_WSBEiJ_G0027378
 protein coding gene Chr4:38257949-38312262 (-)



Homology
more
  • Human Ortholog
    B4GALT1, beta-1,4-galactosyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    B4GALT1, beta-1,4-galactosyltransferase 1
  • Synonyms
    B4GAL-T1, beta4Gal-T1, CDG2D, CLDLFIB, GGTB2, GT1, GTB
  • Links
    NCBI Gene ID: 2683
    neXtProt AC: NX_P15291
    UniProt: P15291

  • Chr Location
    9p21.1; chr9:33104077-33185089 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with B4galt1 mouse models; 2 with human B4GALT1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    79 phenotypes from 4 alleles in 4 genetic backgrounds
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit growth retardation, low viability, excessive epithelial cell proliferation of skin and small intestine, sperm with reduced fertilizing capacity, birthing difficulty, and mammary gland defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    84
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    827
  • Tissues
    110
  • cDNA Data
    173
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028413 Ensembl Gene Model | MGI Sequence Detail 49404 C57BL/6J ±  kb
    transcript ENSMUST00000030121 Ensembl | MGI Sequence Detail 3983 Not Applicable  
    polypeptide ENSMUSP00000030121 Ensembl | MGI Sequence Detail 399 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 182
      Genomic 1
      cDNA 178
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10067, MGI:2140118, MGI:891991
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 27
      Phenotypes 36
    • Earliest
      J:8592 Shaper NL, et al., The gene for galactosyltransferase maps to mouse chromosome 4. Cytogenet Cell Genet. 1987;44(1):18-21
    • Latest
      J:327238 Sun H, et al., Blocking DCIR mitigates colitis and prevents colorectal tumors by enhancing the GM-CSF-STAT5 pathway. Cell Rep. 2022 Aug 2;40(5):111158
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory