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Gja4 Gene Detail
Summary
  • Symbol
    Gja4
  • Name
    gap junction protein, alpha 4
  • Synonyms
    Cnx37, connexin 37, Cx37, Gja-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:95715
    NCBI Gene: 14612
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:127205214-127207832 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 61.47 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    169 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95715
 protein coding gene Chr4:127205213-127207832 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028796
 protein coding gene Chr4:129061477-129064095 (-)
A/J MGP_AJ_G0028755
 protein coding gene Chr4:123971469-123974087 (-)
AKR/J MGP_AKRJ_G0028708
 protein coding gene Chr4:127383791-127386409 (-)
BALB/cJ MGP_BALBcJ_G0028778
 protein coding gene Chr4:124536488-124539106 (-)
C3H/HeJ MGP_C3HHeJ_G0028492
 protein coding gene Chr4:127447631-127450249 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029220
 protein coding gene Chr4:133968206-133970824 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026493
 protein coding gene Chr4:117089181-117091784 (-)
CAST/EiJ MGP_CASTEiJ_G0027925
 protein coding gene Chr4:125580174-125582796 (-)
CBA/J MGP_CBAJ_G0028458
 protein coding gene Chr4:137242095-137244713 (-)
DBA/2J MGP_DBA2J_G0028607
 protein coding gene Chr4:124410909-124413527 (-)
FVB/NJ MGP_FVBNJ_G0028574
 protein coding gene Chr4:123074143-123076761 (-)
LP/J MGP_LPJ_G0028708
 protein coding gene Chr4:129349072-129351690 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028600
 protein coding gene Chr4:142217665-142220287 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029258
 protein coding gene Chr4:127751720-127754338 (-)
PWK/PhJ MGP_PWKPhJ_G0027646
 protein coding gene Chr4:120923872-120926501 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027473
 protein coding gene Chr4:123576101-123578721 (-)
WSB/EiJ MGP_WSBEiJ_G0028005
 protein coding gene Chr4:127858580-127861198 (-)



Homology
more
  • Human Ortholog
    GJA4, gap junction protein alpha 4
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GJA4, gap junction protein alpha 4
  • Synonyms
    CX37
  • Links
    NCBI Gene ID: 2701
    neXtProt AC: NX_P35212
    UniProt: P35212

  • Chr Location
    1p34.3; chr1:34792999-34795747 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human GJA4 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutant females are sterile and oocyte development arrests prior to achieving meiotic competence. There is a lack of mature Graafian follicles, failure to ovulate, and formation of premature corpora lutea.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    926
  • Tissues
    147
  • cDNA Data
    35
  • Literature Summary
    60
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000050234 Ensembl Gene Model | MGI Sequence Detail 2619 C57BL/6J ±  kb
    transcript ENSMUST00000053753 Ensembl | MGI Sequence Detail 1685 Not Applicable  
    polypeptide ENSMUSP00000062320 Ensembl | MGI Sequence Detail 333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 1
      cDNA 36
      Primer pair 12
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10081, MGD-MRK-10087, MGI:2140457, MGI:2140606
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 60
      Gene Ontology 4
      Phenotypes 55
    • Earliest
      J:11073 Willecke K, et al., Six genes of the human connexin gene family coding for gap junctional proteins are assigned to four different human chromosomes. Eur J Cell Biol. 1990 Dec;53(2):275-80
    • Latest
      J:354690 Skelin L, et al., Connexin Expression Is Altered in the Eye Development of Yotari Mice: A Preliminary Study. Biomolecules. 2024 Sep 19;14(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory