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Glo1 Gene Detail
Summary
  • Symbol
    Glo1
  • Name
    glyoxalase 1
  • Synonyms
    0610009E22Rik, 1110008E19Rik, 2510049H23Rik, Glo-1, Glo1-r, Glo-1r, Glo1-s, Glo-1s, Qglo
  • Feature Type
    protein coding gene
  • IDs
    MGI:95742
    NCBI Gene: 109801
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:30811835-30831633 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.69 cM
  • Mapping Data
    64 experiments
Strain
Comparison
more
  • SNPs within 2kb
    656 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95742
 protein coding gene Chr17:30803910-30845845 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023476
 protein coding gene Chr17:30229223-30251812 (-)
A/J MGP_AJ_G0023434
 protein coding gene Chr17:29209801-29234189 (-)
AKR/J MGP_AKRJ_G0023399
 protein coding gene Chr17:29452933-29472864 (-)
BALB/cJ MGP_BALBcJ_G0023439
 protein coding gene Chr17:29410771-29432105 (-)
C3H/HeJ MGP_C3HHeJ_G0023200
 protein coding gene Chr17:29860377-29883264 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023881
 protein coding gene Chr17:31342803-31364302 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021355
 protein coding gene Chr17:26460678-26485386 (-)
CAST/EiJ MGP_CASTEiJ_G0022701
 protein coding gene Chr17:29833252-29871225 (-)
CBA/J MGP_CBAJ_G0023175
 protein coding gene Chr17:32628214-32652432 (-)
DBA/2J MGP_DBA2J_G0023305
 protein coding gene Chr17:28682848-28705644 (-)
FVB/NJ MGP_FVBNJ_G0023275
 protein coding gene Chr17:28510260-28531891 (-)
LP/J MGP_LPJ_G0023383
 protein coding gene Chr17:30473448-30494374 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023293
 protein coding gene Chr17:31818054-31839776 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023923
 protein coding gene Chr17:29897336-29916549 (-)
PWK/PhJ MGP_PWKPhJ_G0022451
 protein coding gene Chr17:27538787-27560894 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022269
 protein coding gene Chr17:27903990-27925364 (-)
WSB/EiJ MGP_WSBEiJ_G0022763
 protein coding gene Chr17:29865976-29888318 (-)



Homology
more
  • Human Ortholog
    GLO1, glyoxalase I
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLO1, glyoxalase I
  • Synonyms
    GLOD1, GLYI, HEL-S-74
  • Links
    NCBI Gene ID: 2739
    neXtProt AC: NX_Q04760
    UniProt: Q04760

  • Chr Location
    6p21.2; chr6:38675925-38703145 (-)  GRCh38
Human Diseases
more
  • Diseases
    5 with human GLO1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show accumulation of a methylglyoxal-derived advanced glycation end product in liver and alterations in anxiety- and depression-like behaviors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    852
  • Tissues
    126
  • cDNA Data
    18
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109801 NCBI Gene Model | MGI Sequence Detail 19799 C57BL/6J ±  kb
    transcript NM_025374 RefSeq | MGI Sequence Detail 1958 ZRU/MplStud  
    polypeptide Q9CPU0 UniProt | EBI | MGI Sequence Detail 184 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 19
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-10120, MGD-MRK-10121, MGD-MRK-10122, MGD-MRK-10124, MGD-MRK-10125, MGD-MRK-10126, MGD-MRK-13737, MGI:1913383, MGI:1917563, MGI:1918922, MGI:2147081, MGI:95743, MGI:95744
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 5
      Gene Ontology 13
      Phenotypes 16
    • Earliest
      J:5879 Meo T, et al., Glyoxalase I polymorphism in the mouse: a new genetic marker linked to H-2. Science. 1977 Oct 21;198(4314):311-3
    • Latest
      J:350557 Dobariya P, et al., Deletion of Glyoxalase 1 Exacerbates Acetaminophen-Induced Hepatotoxicity in Mice. Antioxidants (Basel). 2024 May 25;13(6)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory