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Glud1 Gene Detail
Summary
  • Symbol
    Glud1
  • Name
    glutamate dehydrogenase 1
  • Synonyms
    Gdh-X, Glud
  • Feature Type
    protein coding gene
  • IDs
    MGI:95753
    NCBI Gene: 14661
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:34032684-34066990 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 20.80 cM
  • Mapping Data
    19 experiments
Strain
Comparison
more
  • SNPs within 2kb
    789 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95753
 protein coding gene Chr14:34032684-34067222 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021171
 protein coding gene Chr14:27664443-27701563 (+)
A/J MGP_AJ_G0021119
 protein coding gene Chr14:26591764-26629044 (+)
AKR/J MGP_AKRJ_G0021096
 protein coding gene Chr14:27770739-27806964 (+)
BALB/cJ MGP_BALBcJ_G0021123
 protein coding gene Chr14:26772480-26809870 (+)
C3H/HeJ MGP_C3HHeJ_G0020906
 protein coding gene Chr14:27688595-27727384 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021555
 protein coding gene Chr14:28717458-28757889 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019117
 protein coding gene Chr14:26620606-26653815 (+)
CAST/EiJ MGP_CASTEiJ_G0020431
 protein coding gene Chr14:27509547-27547924 (+)
CBA/J MGP_CBAJ_G0020873
 protein coding gene Chr14:29761526-29802228 (+)
DBA/2J MGP_DBA2J_G0020995
 protein coding gene Chr14:26632384-26665719 (+)
FVB/NJ MGP_FVBNJ_G0020979
 protein coding gene Chr14:26585197-26621640 (+)
LP/J MGP_LPJ_G0021064
 protein coding gene Chr14:27993166-28027001 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021005
 protein coding gene Chr14:28902595-28942099 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021588
 protein coding gene Chr14:27607232-27644932 (+)
PWK/PhJ MGP_PWKPhJ_G0020179
 protein coding gene Chr14:26116688-26150363 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020003
 protein coding gene Chr14:27216619-27251477 (+)
WSB/EiJ MGP_WSBEiJ_G0020486
 protein coding gene Chr14:27662868-27698856 (+)



Homology
more
  • Human Ortholog
    GLUD1, glutamate dehydrogenase 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLUD1, glutamate dehydrogenase 1
  • Synonyms
    GDH, GDH1, GLUD, hGDH1
  • Links
    NCBI Gene ID: 2746
    neXtProt AC: NX_P00367
    UniProt: P00367

  • Chr Location
    10q23.2; chr10:87050202-87094843 (-)  GRCh38
  • Human Ortholog
    GLUD2, glutamate dehydrogenase 2
  • Synonyms
    GDH2, GLUDP1
  • Links
    NCBI Gene ID: 2747
    neXtProt AC: NX_P49448
    UniProt: P49448

  • Chr Location
    Xq24; chrX:121047610-121050094 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human GLUD1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    2 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditionally allele activated in beta cells exhibit reduced glucose-stimulated insulin secretion and disorganization of pancreatic islets.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    857
  • Tissues
    148
  • cDNA Data
    12
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14661 NCBI Gene Model | MGI Sequence Detail 34307 C57BL/6J ±  kb
    transcript NM_008133 RefSeq | MGI Sequence Detail 3158 ZRU/MplStud  
    polypeptide P26443 UniProt | EBI | MGI Sequence Detail 558 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008056 glutamate dehydrogenase 1, mitochondrial
      (term hierarchy)
    • EC
      1.4.1.3
    • InterPro Domains
      IPR046346 Aminoacid dehydrogenase-like, N-terminal domain superfamily
      IPR006095 Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase
      IPR006096 Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, C-terminal
      IPR006097 Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase, dimerisation domain
      IPR033524 Leu/Phe/Val dehydrogenases active site
      IPR033922 NAD(P) binding domain of glutamate dehydrogenase
      IPR036291 NAD(P)-binding domain superfamily
    • GlyGen
      P26443 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 15
      Primer pair 2
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10046, MGD-MRK-10136, MGD-MRK-10139, MGI:2145599
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 7
      Gene Ontology 17
      Phenotypes 24
    • Earliest
      J:8729 Banner C, et al., Isolation of a human brain cDNA for glutamate dehydrogenase. J Neurochem. 1987 Jul;49(1):246-52
    • Latest
      J:353860 Soro-Arnaiz I, et al., GLUD1 determines murine muscle stem cell fate by controlling mitochondrial glutamate levels. Dev Cell. 2024 Aug 2;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory