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Gna14 Gene Detail
Summary
  • Symbol
    Gna14
  • Name
    guanine nucleotide binding protein, alpha 14
  • Synonyms
    G alpha 14
  • Feature Type
    protein coding gene
  • IDs
    MGI:95769
    NCBI Gene: 14675
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:16413126-16588184 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 11.29 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5759 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95769
 protein coding gene Chr19:16413031-16590706 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024959
 protein coding gene Chr19:14165166-14367970 (+)
A/J MGP_AJ_G0024936
 protein coding gene Chr19:13358667-13542348 (+)
AKR/J MGP_AKRJ_G0024906
 protein coding gene Chr19:13904496-14085430 (+)
BALB/cJ MGP_BALBcJ_G0024935
 protein coding gene Chr19:13398249-13576591 (+)
C3H/HeJ MGP_C3HHeJ_G0024693
 protein coding gene Chr19:13845662-14032313 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025377
 protein coding gene Chr19:14736510-14926736 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022796
 protein coding gene Chr19:13801597-13965546 (+)
CAST/EiJ MGP_CASTEiJ_G0024161
 protein coding gene Chr19:13424691-13609885 (+)
CBA/J MGP_CBAJ_G0024671
 protein coding gene Chr19:15184312-15394508 (+)
DBA/2J MGP_DBA2J_G0024803
 protein coding gene Chr19:13399012-13575428 (+)
FVB/NJ MGP_FVBNJ_G0024764
 protein coding gene Chr19:13318784-13493777 (+)
LP/J MGP_LPJ_G0024887
 protein coding gene Chr19:14171083-14358226 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024791
 protein coding gene Chr19:15112539-15308077 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025432
 protein coding gene Chr19:13821862-14010898 (+)
PWK/PhJ MGP_PWKPhJ_G0023910
 protein coding gene Chr19:12928942-13096987 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023715
 protein coding gene Chr19:13123657-13298974 (+)
WSB/EiJ MGP_WSBEiJ_G0024229
 protein coding gene Chr19:13849944-14040394 (+)



Homology
more
  • Human Ortholog
    GNA14, G protein subunit alpha 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNA14, G protein subunit alpha 14
  • Synonyms
    HG1I
  • Links
    NCBI Gene ID: 9630
    neXtProt AC: NX_O95837
    UniProt: O95837

  • Chr Location
    9q21.2; chr9:77423079-77648322 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    853
  • Tissues
    74
  • cDNA Data
    33
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024697 Ensembl Gene Model | MGI Sequence Detail 175059 C57BL/6J ±  kb
transcript ENSMUST00000025602 Ensembl | MGI Sequence Detail 3290 Not Applicable  
polypeptide ENSMUSP00000025602 Ensembl | MGI Sequence Detail 355 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008083 guanine nucleotide-binding protein subunit alpha-14
    (term hierarchy)
  • InterPro Domains
    IPR000654 G-protein alpha subunit, group Q
    IPR011025 G protein alpha subunit, helical insertion
    IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
  • GlyGen
    P30677 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 37
    cDNA 34
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-10178, MGI:2147654
References
more
  • Summaries
    All 48
    Developmental Gene Expression 8
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:10067 Strathmann M, et al., Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7407-9
  • Latest
    J:341358 Park R, et al., Tumor-Promoting Role of GNA14 in Colon Cancer Development. Cancers (Basel). 2023 Sep 15;15(18)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory