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Gnal Gene Detail
Summary
  • Symbol
    Gnal
  • Name
    guanine nucleotide binding protein, alpha stimulating, olfactory type
  • Synonyms
    2610011C15Rik, 9630020G10Rik, G alpha 10, Galphaolf, Gna10, Golf
  • Feature Type
    protein coding gene
  • IDs
    MGI:95774
    NCBI Gene: 14680
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:67221369-67359863 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 39.85 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4504 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95774
 protein coding gene Chr18:67221287-67359863 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024519
 protein coding gene Chr18:67340516-67493245 (+)
A/J MGP_AJ_G0024486
 protein coding gene Chr18:64397253-64544745 (+)
AKR/J MGP_AKRJ_G0024456
 protein coding gene Chr18:66299914-66443717 (+)
BALB/cJ MGP_BALBcJ_G0024485
 protein coding gene Chr18:64567907-64711749 (+)
C3H/HeJ MGP_C3HHeJ_G0024253
 protein coding gene Chr18:66457466-66600175 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024932
 protein coding gene Chr18:69143469-69286802 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022363
 protein coding gene Chr18:63781511-63928062 (+)
CAST/EiJ MGP_CASTEiJ_G0023726
 protein coding gene Chr18:66435239-66586455 (+)
CBA/J MGP_CBAJ_G0024223
 protein coding gene Chr18:71499471-71661418 (+)
DBA/2J MGP_DBA2J_G0024353
 protein coding gene Chr18:64062333-64205198 (+)
FVB/NJ MGP_FVBNJ_G0024319
 protein coding gene Chr18:63433635-63576216 (+)
LP/J MGP_LPJ_G0024437
 protein coding gene Chr18:67207537-67357326 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024348
 protein coding gene Chr18:72796499-72947261 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024979
 protein coding gene Chr18:66460561-66606846 (+)
PWK/PhJ MGP_PWKPhJ_G0023469
 protein coding gene Chr18:64335222-64479112 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023274
 protein coding gene Chr18:66614537-66757312 (+)
WSB/EiJ MGP_WSBEiJ_G0023790
 protein coding gene Chr18:66340269-66484905 (+)



Homology
more
  • Human Ortholog
    GNAL, G protein subunit alpha L
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNAL, G protein subunit alpha L
  • Synonyms
    DYT25, HG1O
  • Links
    NCBI Gene ID: 2774
    neXtProt AC: NX_P38405
    UniProt: P38405

  • Chr Location
    18p11.21; chr18:11689264-11885685 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GNAL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous for a targeted mutation fail to feed, and ~75% die within 2 days after birth. Rare survivors reach sexual maturity and mate but are hyperactive and anosmic, exhibitng severely reduced odor-evoked electrophysical responses and significantly perturbed maternal behaviors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    13
  • cDNA Data
    14
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14680 NCBI Gene Model | MGI Sequence Detail 138495 C57BL/6J ±  kb
    transcript NM_177137 RefSeq | MGI Sequence Detail 5654 ZRU/MplStud  
    polypeptide Q8CGK7 UniProt | EBI | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000008088 guanine nucleotide-binding protein G(olf) subunit alpha
      (term hierarchy)
    • PDB
      8HTG
    • InterPro Domains
      IPR000367 G-protein alpha subunit, group S
      IPR011025 G protein alpha subunit, helical insertion
      IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q8CGK7 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 17
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10174, MGD-MRK-10186, MGI:1919713, MGI:2147266, MGI:2443840, MGI:95765
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 19
      Gene Ontology 11
      Phenotypes 25
    • Earliest
      J:10067 Strathmann M, et al., Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. Proc Natl Acad Sci U S A. 1989 Oct;86(19):7407-9
    • Latest
      J:326068 Aissa HB, et al., Functional abnormalities in the cerebello-thalamic pathways in a mouse model of DYT25 dystonia. Elife. 2022 Jun 14;11:e79135
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory