Gpt MGI Mouse Gene Detail - MGI:95802 - glutamic pyruvic transaminase, soluble

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Gpt Gene Detail

Symbol

Gpt
Name

glutamic pyruvic transaminase, soluble
Synonyms

1300007J06Rik, 2310022B03Rik, ALT, Gpt-1, Gpt1

Feature Type

protein coding gene
IDs

MGI:95802
NCBI Gene: 76282
Alliance

gene page
Transcription Start Sites

4 TSS
Candidate for QTL

4 QTL

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Sequence Map

Chr15:76580926-76583875 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 36.28 cM, cytoband D3
Mapping Data

30 experiments

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SNPs within 2kb

119 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_95802	protein coding gene	Chr15:76579916-76583886 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022007	protein coding gene	Chr15:76798851-76801764 (+)
A/J	MGP_AJ_G0021965	protein coding gene	Chr15:73984077-73986961 (+)
AKR/J	MGP_AKRJ_G0021948	protein coding gene	Chr15:75992657-75995558 (+)
BALB/cJ	MGP_BALBcJ_G0021974	protein coding gene	Chr15:74009801-74012725 (+)
C3H/HeJ	MGP_C3HHeJ_G0021746	protein coding gene	Chr15:76039925-76042844 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022414	protein coding gene	Chr15:79660016-79662931 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019943	protein coding gene	Chr15:70642739-70645625 (+)
CAST/EiJ	MGP_CASTEiJ_G0021265	protein coding gene	Chr15:76846281-76849240 (+)
CBA/J	MGP_CBAJ_G0021713	protein coding gene	Chr15:82181646-82184577 (+)
DBA/2J	MGP_DBA2J_G0021838	protein coding gene	Chr15:73521264-73525229 (+)
FVB/NJ	MGP_FVBNJ_G0021818	protein coding gene	Chr15:72580307-72583226 (+)
LP/J	MGP_LPJ_G0021909	protein coding gene	Chr15:76879926-76882877 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021843	protein coding gene	Chr15:87523800-87532215 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022434	protein coding gene	Chr15:76267324-76270277 (+)
PWK/PhJ	MGP_PWKPhJ_G0021006	protein coding gene	Chr15:73687682-73690611 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020846	protein coding gene	Chr15:75962127-75965960 (+)
WSB/EiJ	MGP_WSBEiJ_G0021317	protein coding gene	Chr15:76358540-76361449 (+)

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Human Ortholog

GPT, glutamic--pyruvic transaminase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPT, glutamic--pyruvic transaminase
Synonyms

AAT1, ALT, ALT1, GPT1, SGPT
Links

HGNC:4552

NCBI Gene ID: 2875

neXtProt AC: NX_P24298

UniProt: P24298
Chr Location

8q24.3; chr8:144502973-144507174 (+) GRCh38

MGI Vertebrate Homology

Gpt stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GPT
Gene Tree

Gpt

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References

1 with disease annotations

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Phenotype Summary

29 phenotype references

All Mutations and Alleles

11
Chemically induced (other)

3
Endonuclease-mediated

2
Radiation induced

2
Targeted

4
Genomic Mutations

5 involving Gpt
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

24 strains or lines available

Electrophoretic variants are detected in C57BL/6, BALB/c and DBA/2 (a allele); in MA/J and NZB/Bl (b allele). M. m. molossinus and M. m. castaneus have either the b or c allele. In liver, GPT1 activity rises dramatically at 12-19 days to adult levels.

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All GO Annotations

12
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

847
Tissues

112
cDNA Data

12
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpt

ZFIN gpt

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All Sequences

54
RefSeq

2
UniProt

5
CCDS

CCDS27586.1

Ensembl

ENSMUSG00000022546 (Evidence)
NCBI Gene

76282

Representative Sequences				Length	Strain/Species	Flank
	genomic	76282	NCBI Gene Model \| MGI Sequence Detail	2950	C57BL/6J	± kb
	transcript	NM_182805	RefSeq \| MGI Sequence Detail	1809	ZRU/MplStud
	polypeptide	Q8QZR5	UniProt \| EBI \| MGI Sequence Detail	496	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000008208 alanine aminotransferase 1

(term hierarchy)
EC

2.6.1.2
InterPro Domains

IPR045088 Aminotransferase ALAT1/2-like

IPR004839 Aminotransferase, class I/classII

IPR015424 Pyridoxal phosphate-dependent transferase

IPR015421 Pyridoxal phosphate-dependent transferase, major domain

IPR015422 Pyridoxal phosphate-dependent transferase, small domain
GlyGen

Q8QZR5 1 site, 1 O-linked glycan (1 site)

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All nucleic 12

cDNA 12

Microarray probesets 4

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MGD-MRK-10236, MGD-MRK-10237, MGI:1915263, MGI:1923532

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Summaries

All 79

Developmental Gene Expression 2

Diseases 1

Gene Ontology 8

Phenotypes 29
Earliest

J:5384 Chen SH, et al., The genetics of glutamic-pyruvic transaminase in mice: inheritance, electrophoretic phenotypes, and postnatal changes. Biochem Genet. 1973 Sep;10(1):23-8
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gpt:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131817	Chr15:76579885-76579902 (+)	-1,032 bp
Tssr131818	Chr15:76579965-76579987 (+)	-950 bp
Tssr131819	Chr15:76580925-76580947 (+)	10 bp
Tssr131820	Chr15:76582372-76582421 (+)	1,471 bp

Gpt is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bw11	Chr15, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
Bwtq6	Chr15, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
Dbsty4	Chr15, 41.96 cM	Chr15:87349271-87349416	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
Mobq4	Chr15, 1.84 cM	Chr15:3489694-3489829	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.

*cM position of peak correlated region/marker

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