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Gsr Gene Detail
Summary
  • Symbol
    Gsr
  • Name
    glutathione reductase
  • Synonyms
    D8Ertd238e, Gr-1, Gr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95804
    NCBI Gene: 14782
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:34143266-34188190 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 20.69 cM
  • Mapping Data
    31 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1647 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95804
 protein coding gene Chr8:34142551-34188191 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033526
 protein coding gene Chr8:32112708-32160692 (+)
A/J MGP_AJ_G0033506
 protein coding gene Chr8:30886719-30932737 (+)
AKR/J MGP_AKRJ_G0033430
 protein coding gene Chr8:31854063-31899556 (+)
BALB/cJ MGP_BALBcJ_G0033502
 protein coding gene Chr8:31003741-31052945 (+)
C3H/HeJ MGP_C3HHeJ_G0033214
 protein coding gene Chr8:32175340-32222282 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034018
 protein coding gene Chr8:33346326-33395621 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030967
 protein coding gene Chr8:27688542-27733395 (+)
CAST/EiJ MGP_CASTEiJ_G0032541
 protein coding gene Chr8:31602744-31661437 (+)
CBA/J MGP_CBAJ_G0033192
 protein coding gene Chr8:34657392-34705082 (+)
DBA/2J MGP_DBA2J_G0033345
 protein coding gene Chr8:30865135-30912437 (+)
FVB/NJ MGP_FVBNJ_G0033290
 protein coding gene Chr8:30527056-30572971 (+)
LP/J MGP_LPJ_G0033435
 protein coding gene Chr8:32066239-32119587 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033332
 protein coding gene Chr8:34187774-34238376 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034037
 protein coding gene Chr8:31927820-31975713 (+)
PWK/PhJ MGP_PWKPhJ_G0032253
 protein coding gene Chr8:30379456-30425113 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032084
 protein coding gene Chr8:31211622-31256173 (+)
WSB/EiJ MGP_WSBEiJ_G0032657
 protein coding gene Chr8:32072689-32117943 (+)



Homology
more
  • Human Ortholog
    GSR, glutathione-disulfide reductase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSR, glutathione-disulfide reductase
  • Synonyms
    CNSHA10, GR, GSRD, HEL-75, HEL-S-122m
  • Links
    NCBI Gene ID: 2936
    neXtProt AC: NX_P00390
    UniProt: P00390

  • Chr Location
    8p12; chr8:30678066-30727846 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GSR associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A homozygous mutation disrupting this gene between exon 1-2 results in a decreased retinal artery-to-vein ratio. Another small deletion of exons 2-5 has no phenotypic effect. Electrophoretic alleles designated a (C57BL/6, CE) vs. allele b (SJL, SWR) are known.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    25
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    36
  • cDNA Data
    22
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14782 NCBI Gene Model | MGI Sequence Detail 44925 C57BL/6J ±  kb
transcript NM_010344 RefSeq | MGI Sequence Detail 2692 ZRU/MplStud  
polypeptide P47791 UniProt | EBI | MGI Sequence Detail 500 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000008292 glutathione reductase, mitochondrial
    (term hierarchy)
  • EC
    1.8.1.7
  • InterPro Domains
    IPR016156 FAD/NAD-linked reductase, dimerisation domain superfamily
    IPR023753 FAD/NAD(P)-binding domain
    IPR036188 FAD/NAD(P)-binding domain superfamily
    IPR006322 Glutathione reductase, eukaryote/bacterial
    IPR046952 Glutathione reductase/thioredoxin reductase-like
    IPR001100 Pyridine nucleotide-disulphide oxidoreductase, class I
    IPR012999 Pyridine nucleotide-disulphide oxidoreductase, class I, active site
    IPR004099 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
  • GlyGen
    P47791 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 29
    Genomic 4
    cDNA 23
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10240, MGD-MRK-10241, MGI:1098700, MGI:1196262, MGI:2142510, MGI:2175898
References
more
  • Summaries
    All 94
    Developmental Gene Expression 8
    Gene Ontology 14
    Phenotypes 22
  • Earliest
    J:5572 Nichols EA, et al., Polymorphism and linkage of glutathione reductase in Mus musculus. Biochem Genet. 1975 Jun;13(5-6):323-9
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory