Tle5 MGI Mouse Gene Detail - MGI:95806 - TLE family member 5, transcriptional modulator

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Tle5 Gene Detail

Symbol

Tle5
Name

TLE family member 5, transcriptional modulator
Synonyms

Aes, AES, Grg, Grg5

Feature Type

protein coding gene
IDs

MGI:95806
NCBI Gene: 14797
Alliance

gene page
Transcription Start Sites

17 TSS
Candidate for QTL

2 QTL

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Sequence Map

Chr10:81395322-81402196 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 39.72 cM
Mapping Data

5 experiments

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SNPs within 2kb

149 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_95806	protein coding gene	Chr10:81395278-81402205 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017565	protein coding gene	Chr10:82290893-82298111 (+)
A/J	MGP_AJ_G0017543	protein coding gene	Chr10:79366316-79373445 (+)
AKR/J	MGP_AKRJ_G0017504	protein coding gene	Chr10:81541945-81548873 (+)
BALB/cJ	MGP_BALBcJ_G0017505	protein coding gene	Chr10:79591518-79598384 (+)
C3H/HeJ	MGP_C3HHeJ_G0017328	protein coding gene	Chr10:81649922-81658234 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017959	protein coding gene	Chr10:85107923-85116520 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015648	protein coding gene	Chr10:75562166-75569096 (+)
CAST/EiJ	MGP_CASTEiJ_G0016895	protein coding gene	Chr10:81895675-81902528 (+)
CBA/J	MGP_CBAJ_G0017300	protein coding gene	Chr10:88451858-88462951 (+)
DBA/2J	MGP_DBA2J_G0017406	protein coding gene	Chr10:78570417-78577754 (+)
FVB/NJ	MGP_FVBNJ_G0017400	protein coding gene	Chr10:77839304-77846881 (+)
LP/J	MGP_LPJ_G0017477	protein coding gene	Chr10:82739366-82748631 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017426	protein coding gene	Chr10:90274389-90281280 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018000	protein coding gene	Chr10:81562058-81569099 (+)
PWK/PhJ	MGP_PWKPhJ_G0016676	protein coding gene	Chr10:78477249-78484164 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016466	protein coding gene	Chr10:80507720-80514495 (+)
WSB/EiJ	MGP_WSBEiJ_G0016955	protein coding gene	Chr10:81606544-81614824 (+)

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Human Ortholog

TLE5, TLE family member 5, transcriptional modulator

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TLE5, TLE family member 5, transcriptional modulator
Synonyms

AES, AES-1, AES-2, ESP1, GRG, Grg-5, GRG5
Links

HGNC:307

NCBI Gene ID: 166

neXtProt AC: NX_Q08117

UniProt: Q08117
Chr Location

19p13.3; chr19:3052910-3063107 (-) GRCh38

MGI Vertebrate Homology

Tle5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TLE5
Gene Tree

Tle5

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Phenotype Summary

9 phenotypes from 3 alleles in 2 genetic backgrounds
22 phenotypes from multigenic genotypes
27 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

10
Targeted

4
Transgenic

3
Genomic Mutations

1 involving Tle5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele display altered mating frequency, abnormal pituitary gland growth and development, and varying degrees of postnatal growth retardation leading to premature death among severely runted individuals.

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All GO Annotations

29
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

949
Tissues

210
cDNA Data

246
Literature Summary

22

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tle5

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All Sequences

59
RefSeq

5
UniProt

4
CCDS

CCDS24062.1

Ensembl

ENSMUSG00000054452 (Evidence)
NCBI Gene

14797

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000054452	Ensembl Gene Model \| MGI Sequence Detail	6875	C57BL/6J	± kb
	transcript	ENSMUST00000002518	Ensembl \| MGI Sequence Detail	1411	Not Applicable
	polypeptide	ENSMUSP00000002518	Ensembl \| MGI Sequence Detail	197	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000003800 TLE family member 5

(term hierarchy)
InterPro Domains

IPR005617 Groucho/TLE, N-terminal Q-rich domain

IPR009146 Groucho/transducin-like enhancer

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All nucleic 251

Genomic 1

cDNA 247

Primer pair 3

Microarray probesets 3

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MGD-MRK-10244, MGI:2143713, MGI:6286351

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Summaries

All 77

Developmental Gene Expression 22

Gene Ontology 7

Phenotypes 27
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:343425 Andreani C, et al., SIRT6 promotes metastasis and relapse in HER2-positive breast cancer. Sci Rep. 2023 Dec 12;13(1):22000

TSS for Tle5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr94772	Chr10:81395262-81395278 (+)	-52 bp
Tssr94773	Chr10:81395281-81395332 (+)	-15 bp
Tssr94774	Chr10:81395358-81395417 (+)	66 bp
Tssr94775	Chr10:81395420-81395429 (+)	103 bp
Tssr3288	Chr10:81395448-81395453 (+)	129 bp
Tssr94776	Chr10:81397043-81397093 (+)	1,746 bp
Tssr94777	Chr10:81399660-81399679 (+)	4,348 bp
Tssr94778	Chr10:81399919-81399956 (+)	4,616 bp
Tssr94779	Chr10:81400279-81400290 (+)	4,963 bp
Tssr94780	Chr10:81400492-81400524 (+)	5,186 bp
Tssr94781	Chr10:81401371-81401397 (+)	6,062 bp
Tssr94782	Chr10:81401497-81401521 (+)	6,187 bp
Tssr94783	Chr10:81401540-81401567 (+)	6,232 bp
Tssr94784	Chr10:81401571-81401600 (+)	6,264 bp
Tssr94785	Chr10:81401622-81401633 (+)	6,306 bp
Tssr94786	Chr10:81401696-81401712 (+)	6,382 bp
Tssr94787	Chr10:81401792-81401811 (+)	6,480 bp

Tle5 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Igfbp3q2	Chr10, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 10, candidate genes for diabesity QTL Igfp3q2 (46 cM) are Aes (43 cM) and Hsp90b1 (49 cM). Aes shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets while Hsp90b1 shows differential expression between the restricted and unrestricted diets on the A/A background. At another locus, Mdm2 (66 cM) is a candidate gene for diabesity QTL Insq4 (59 cM). Mdm2 shows differential expression between the restricted and unrestricted diets on the A/a background.
Insq4	Chr10, 54.72 cM	Chr10:103909085-103909229	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 10, candidate genes for diabesity QTL Igfp3q2 (46 cM) are Aes (43 cM) and Hsp90b1 (49 cM). Aes shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets while Hsp90b1 shows differential expression between the restricted and unrestricted diets on the A/A background. At another locus, Mdm2 (66 cM) is a candidate gene for diabesity QTL Insq4 (59 cM). Mdm2 shows differential expression between the restricted and unrestricted diets on the A/a background.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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