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Gria4 Gene Detail
Summary
  • Symbol
    Gria4
  • Name
    glutamate receptor, ionotropic, AMPA4 (alpha 4)
  • Synonyms
    Glur-4, Glur4, Gluralpha4, spkw1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95811
    NCBI Gene: 14802
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:4417896-4796234 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9597 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95811
 protein coding gene Chr9:4417893-4796250 (-)
129S1/SvImJ ENSMUSG00200022578
 protein coding gene Chr9:1247314-1619469 (-)
A/J ENSMUSG00195018366
 protein coding gene Chr9:1177019-1555444 (-)
AKR/J ENSMUSG00220018551
 protein coding gene Chr9:1305338-1682455 (-)
BALB/cJ ENSMUSG00180011303
 protein coding gene Chr9:1317649-1696070 (-)
C3H/HeJ ENSMUSG00175023117
 protein coding gene Chr9:1239688-1623473 (-)
C57BL/6NJ ENSMUSG00215005831
 protein coding gene Chr9:1253499-1631961 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031742
 protein coding gene Chr9:901982-1275664 (-)
CAST/EiJ ENSTCUG00005007131
 protein coding gene Chr9:1345188-1719399 (-)
CBA/J ENSMUSG00210010567
 protein coding gene Chr9:1183895-1563887 (-)
DBA/2J ENSMUSG00185005066
 protein coding gene Chr9:1385643-1764021 (-)
FVB/NJ ENSMUSG00205006912
 protein coding gene Chr9:1359636-1738056 (-)
JF1/MsJ ENSUMUG00000005734
 protein coding gene Chr9:1370807-1741868 (-)
LP/J ENSMUSG00230003600
 protein coding gene Chr9:1837862-2216697 (-)
NOD/ShiLtJ ENSMUSG00190021517
 protein coding gene Chr9:1274698-1653703 (-)
NZO/HlLtJ ENSMUSG00225016718
 protein coding gene Chr9:1717827-2096211 (-)
PWK/PhJ ENSLUMG00010006334
 protein coding gene Chr9:1335410-1710412 (-)
SPRET/EiJ ENSMSPG00010005268
 protein coding gene Chr9:1360519-1739259 (-)
WSB/EiJ ENSIUOG00005007363
 protein coding gene Chr9:1162242-1534595 (-)



Homology
more
  • Human Ortholog
    GRIA4, glutamate ionotropic receptor AMPA type subunit 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIA4, glutamate ionotropic receptor AMPA type subunit 4
  • Synonyms
    GluA4, GluA4-ATD, GLUR4, GLUR4C, GLURD, NEDSGA
  • Links
    NCBI Gene ID: 2893
    UniProt: P48058

  • Chr Location
    11q22.3; chr11:105609535-105982090 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GRIA4 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 6 alleles in 10 genetic backgrounds
    4 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation display hyperactivity, decreased thermal nociception, and abnormal sensitivity to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    65
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    965
  • Tissues
    170
  • cDNA Data
    31
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025892 Ensembl Gene Model | MGI Sequence Detail 378339 C57BL/6J ±  kb
    transcript ENSMUST00000212533 Ensembl | MGI Sequence Detail 5207 Not Applicable  
    polypeptide ENSMUSP00000148533 Ensembl | MGI Sequence Detail 902 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000008236 glutamate receptor 4
      (term hierarchy)
    • InterPro Domains
      IPR015683 Ionotropic glutamate receptor
      IPR001320 Ionotropic glutamate receptor, C-terminal
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      Q9Z2W8 7 sites, 10 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 1
      cDNA 36
      Primer pair 2
      Antibodies 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10143, MGD-MRK-10150, MGD-MRK-10249, MGI:3580137
    References
    more
    • Summaries
      All 113
      Developmental Gene Expression 17
      Gene Ontology 14
      Phenotypes 32
    • Earliest
      J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
    • Latest
      J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory