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Grin2a Gene Detail
Summary
  • Symbol
    Grin2a
  • Name
    glutamate receptor, ionotropic, NMDA2A (epsilon 1)
  • Synonyms
    GluN2A, GluRepsilon1, NMDAR2A, NR2A
  • Feature Type
    protein coding gene
  • IDs
    MGI:95820
    NCBI Gene: 14811
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:9385762-9813424 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 5.28 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11499 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95820
 protein coding gene Chr16:9385762-9813744 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022501
 protein coding gene Chr16:6305626-6748053 (-)
A/J MGP_AJ_G0022463
 protein coding gene Chr16:5962515-6391998 (-)
AKR/J MGP_AKRJ_G0022439
 protein coding gene Chr16:6261541-6707383 (-)
BALB/cJ MGP_BALBcJ_G0022467
 protein coding gene Chr16:6094349-6523676 (-)
C3H/HeJ MGP_C3HHeJ_G0022234
 protein coding gene Chr16:6299422-6742563 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022916
 protein coding gene Chr16:6456750-6911800 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020437
 protein coding gene Chr16:6126339-6536053 (-)
CAST/EiJ MGP_CASTEiJ_G0021761
 protein coding gene Chr16:6331256-6767314 (-)
CBA/J MGP_CBAJ_G0022203
 protein coding gene Chr16:6718592-7176741 (-)
DBA/2J MGP_DBA2J_G0022334
 protein coding gene Chr16:5975263-6404572 (-)
FVB/NJ MGP_FVBNJ_G0022310
 protein coding gene Chr16:5960675-6391122 (-)
LP/J MGP_LPJ_G0022402
 protein coding gene Chr16:6274580-6716481 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022332
 protein coding gene Chr16:6472102-6914436 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022929
 protein coding gene Chr16:6203682-6650024 (-)
PWK/PhJ MGP_PWKPhJ_G0021501
 protein coding gene Chr16:6174187-6598550 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021331
 protein coding gene Chr16:6262394-6710254 (-)
WSB/EiJ MGP_WSBEiJ_G0021809
 protein coding gene Chr16:6241951-6695669 (-)



Homology
more
  • Human Ortholog
    GRIN2A, glutamate ionotropic receptor NMDA type subunit 2A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIN2A, glutamate ionotropic receptor NMDA type subunit 2A
  • Synonyms
    EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A
  • Links
    NCBI Gene ID: 2903
    neXtProt AC: NX_Q12879
    UniProt: Q12879

  • Chr Location
    16p13.2; chr16:9753404-10182928 (-)  GRCh38
Human Diseases
more
  • Diseases
    6 with human GRIN2A associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 7 alleles in 8 genetic backgrounds
    10 phenotypes from multigenic genotypes
    126 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit jumpiness, mildly impaired long-term potentiation and spatial learning, increased locomotor activity and metabolism of dopamine and serotonin, and loss of analgesic tolerance after repeated morphine doses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    180
  • GO References
    75
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    993
  • Tissues
    99
  • cDNA Data
    8
  • Literature Summary
    48
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000059003 Ensembl Gene Model | MGI Sequence Detail 427663 C57BL/6J ±  kb
transcript ENSMUST00000032331 Ensembl | MGI Sequence Detail 4395 Not Applicable  
polypeptide ENSMUSP00000032331 Ensembl | MGI Sequence Detail 1464 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008246 glutamate receptor ionotropic, NMDA 2A
    (term hierarchy)
  • InterPro Domains
    IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminal
    IPR015683 Ionotropic glutamate receptor
    IPR001320 Ionotropic glutamate receptor, C-terminal
    IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
    IPR001508 Ionotropic glutamate receptor, metazoa
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
  • GlyGen
    P35436 11 sites, 8 N-linked glycans (9 sites)
Molecular
Reagents
less
  • All nucleic 24
    Genomic 3
    cDNA 10
    Primer pair 2
    Other 9

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10258
References
more
  • Summaries
    All 316
    Developmental Gene Expression 48
    Gene Ontology 75
    Phenotypes 126
  • Earliest
    J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
  • Latest
    J:346087 Lu Y, et al., Differential depletion of GluN2A induces heterogeneous schizophrenia-related phenotypes in mice. EBioMedicine. 2024 Mar 11;102:105045
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory