Gsc MGI Mouse Gene Detail - MGI:95841 - goosecoid homeobox

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Gsc Gene Detail

Symbol

Gsc
Name

goosecoid homeobox
Synonyms

goosecoid

Feature Type

protein coding gene
IDs

MGI:95841
NCBI Gene: 14836
Alliance

gene page
Transcription Start Sites

2 TSS
Candidate for QTL

2 QTL

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Sequence Map

Chr12:104437468-104439495 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 54.32 cM
Mapping Data

3 experiments

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SNPs within 2kb

127 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_95841	protein coding gene	Chr12:104437468-104439589 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020077	protein coding gene	Chr12:106268839-106270961 (-)
A/J	MGP_AJ_G0020031	protein coding gene	Chr12:102231255-102233376 (-)
AKR/J	MGP_AKRJ_G0020008	protein coding gene	Chr12:105183140-105185261 (-)
BALB/cJ	MGP_BALBcJ_G0020017	protein coding gene	Chr12:102645951-102648072 (-)
C3H/HeJ	MGP_C3HHeJ_G0019820	protein coding gene	Chr12:105642307-105644428 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020463	protein coding gene	Chr12:109575758-109577879 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018076	protein coding gene	Chr12:98942082-98944201 (-)
CAST/EiJ	MGP_CASTEiJ_G0019361	protein coding gene	Chr12:100461207-100469675 (-)
CBA/J	MGP_CBAJ_G0019787	protein coding gene	Chr12:113787597-113789718 (-)
DBA/2J	MGP_DBA2J_G0019904	protein coding gene	Chr12:101780612-101782733 (-)
FVB/NJ	MGP_FVBNJ_G0019889	protein coding gene	Chr12:100562464-100564586 (-)
LP/J	MGP_LPJ_G0019979	protein coding gene	Chr12:106139734-106141856 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019927	protein coding gene	Chr12:117264496-117266617 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020492	protein coding gene	Chr12:104607177-104609298 (-)
PWK/PhJ	MGP_PWKPhJ_G0019124	protein coding gene	Chr12:96278250-96286924 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018926	protein coding gene	Chr12:98872263-98874386 (-)
WSB/EiJ	MGP_WSBEiJ_G0019420	protein coding gene	Chr12:105585253-105587375 (-)

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Human Ortholog

GSC, goosecoid homeobox

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GSC, goosecoid homeobox
Synonyms

GSC1, SAMS
Links

HGNC:4612

NCBI Gene ID: 145258

neXtProt AC: NX_P56915

UniProt: P56915
Chr Location

14q32.13; chr14:94768223-94770113 (-) GRCh38

MGI Vertebrate Homology

Gsc stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GSC
Gene Tree

Gsc

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Phenotype Summary

72 phenotypes from 2 alleles in 5 genetic backgrounds
39 phenotypes from multigenic genotypes
24 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Gene trapped

3
Targeted

5
Genomic Mutations

1 involving Gsc
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit craniofacial abnormalities affecting the mandible, nasal cavities and pits, tongue, and inner ear, and skeletal defects involving ribs, sternum, shoulder and hip. Mutants die neonatally.

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All GO Annotations

33
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1523
Tissues

388
cDNA Data

15
Literature Summary

171

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GSC

Xenbase gsc

ZFIN gsc

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS26153.1

Ensembl

ENSMUSG00000021095 (Evidence)
NCBI Gene

14836

Representative Sequences				Length	Strain/Species	Flank
	genomic	14836	NCBI Gene Model \| MGI Sequence Detail	2028	C57BL/6J	± kb
	transcript	NM_010351	RefSeq \| MGI Sequence Detail	1183	ZRU/MplStud
	polypeptide	Q02591	UniProt \| EBI \| MGI Sequence Detail	256	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008278 homeobox protein goosecoid

(term hierarchy)
InterPro Domains

IPR051440 Goosecoid-like homeobox

IPR017970 Homeobox, conserved site

IPR001356 Homeobox domain

IPR009057 Homeobox-like domain superfamily

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All nucleic 60

Genomic 8

cDNA 16

Primer pair 10

Other 26

Microarray probesets 3

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MGD-MRK-10283

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Summaries

All 218

Developmental Gene Expression 171

Gene Ontology 12

Phenotypes 24
Earliest

J:1337 Blum M, et al., Gastrulation in the mouse: the role of the homeobox gene goosecoid. Cell. 1992 Jun 26;69(7):1097-106
Latest

J:347618 Qin T, et al., Ptch1 is essential for cochlear marginal cell differentiation and stria vascularis formation. Cell Rep. 2024 Apr 23;43(4):114083

TSS for Gsc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr117577	Chr12:104439625-104439632 (-)	-134 bp
Tssr117576	Chr12:104439495-104439513 (-)	-9 bp

Gsc is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Dbsty3	Chr12, 50.87 cM	Chr12:100532075-100532224	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 12, Gsc (52 cM) shows differential expression between A/a and A/A animals on the restricted diet. Diabesity QTLs Dbsty3 (48 cM) and Mob3 (53 cM) map near candidate gene Gsc.
Mobq3	Chr12, 57.30 cM	Chr12:106664071-106664351	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 12, Gsc (52 cM) shows differential expression between A/a and A/A animals on the restricted diet. Diabesity QTLs Dbsty3 (48 cM) and Mob3 (53 cM) map near candidate gene Gsc.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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