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Gstm2 Gene Detail
Summary
  • Symbol
    Gstm2
  • Name
    glutathione S-transferase, mu 2
  • Synonyms
    Gstb-2, Gstb2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95861
    NCBI Gene: 14863
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:107889018-107893736 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 46.83 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    245 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95861
 protein coding gene Chr3:107889018-107893769 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027761
 protein coding gene Chr3:109509390-109514357 (-)
A/J MGP_AJ_G0027721
 protein coding gene Chr3:106037888-106042260 (-)
AKR/J MGP_AKRJ_G0027686
 protein coding gene Chr3:108619263-108624001 (-)
BALB/cJ MGP_BALBcJ_G0027733
 protein coding gene Chr3:105727898-105739477 (-)
C3H/HeJ MGP_C3HHeJ_G0027463
 protein coding gene Chr3:108960074-108965999 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028177
 protein coding gene Chr3:113598038-113602410 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025514
 protein coding gene Chr3:102141176-102195911 (-)
CAST/EiJ MGP_CASTEiJ_G0026918
 protein coding gene Chr3:108298664-108348993 (-)
CBA/J MGP_CBAJ_G0027438
 protein coding gene Chr3:117459442-117464137 (-)
DBA/2J MGP_DBA2J_G0027580
 protein coding gene Chr3:105224385-105228757 (-)
FVB/NJ MGP_FVBNJ_G0027548
 protein coding gene Chr3:103106888-103111756 (-)
LP/J MGP_LPJ_G0027687
 protein coding gene Chr3:110930449-110935537 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027578
 protein coding gene Chr3:123521865-123526482 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028232
 protein coding gene Chr3:108215187-108219986 (-)
PWK/PhJ MGP_PWKPhJ_G0026644
 protein coding gene Chr3:104928162-104976721 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026464
 protein coding gene Chr3:106308445-106358280 (-)
WSB/EiJ MGP_WSBEiJ_G0026998
 protein coding gene Chr3:108693633-108746160 (-)



Homology
more
  • Human Ortholog
    GSTM1, glutathione S-transferase mu 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSTM1, glutathione S-transferase mu 1
  • Synonyms
    GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, H-B, MU, MU-1
  • Links
    NCBI Gene ID: 2944
    neXtProt AC: NX_P09488
    UniProt: P09488

  • Chr Location
    1p13.3; chr1:109687814-109709039 (+)  GRCh38
  • Human Ortholog
    GSTM5, glutathione S-transferase mu 5
  • Synonyms
    GSTM5-5, GTM5
  • Links
    NCBI Gene ID: 2949
    neXtProt AC: NX_P46439
    UniProt: P46439

  • Chr Location
    1p13.3; chr1:109711751-109775428 (+)  GRCh38
Human Diseases
more
  • Diseases
    105 with human GSTM1,GSTM5 associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    870
  • Tissues
    159
  • cDNA Data
    302
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 14863 NCBI Gene Model | MGI Sequence Detail 4719 C57BL/6J ±  kb
transcript NM_008183 RefSeq | MGI Sequence Detail 1045 C57BL/6  
polypeptide P15626 UniProt | EBI | MGI Sequence Detail 218 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • EC
    2.5.1.18
  • InterPro Domains
    IPR004046 Glutathione S-transferase, C-terminal
    IPR036282 Glutathione S-transferase, C-terminal domain superfamily
    IPR010987 Glutathione S-transferase, C-terminal-like
    IPR003081 Glutathione S-transferase, Mu class
    IPR004045 Glutathione S-transferase, N-terminal
    IPR050213 Glutathione S-transferase superfamily
    IPR040079 Glutathione transferase family
    IPR036249 Thioredoxin-like superfamily
  • GlyGen
    P15626 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 304
    cDNA 302
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10315, MGD-MRK-10319
References
more
  • Summaries
    All 44
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:10167 Townsend AJ, et al., Isolation, characterization, and expression in Escherichia coli of two murine Mu class glutathione S-transferase cDNAs homologous to the rat subunits 3 (Yb1) and 4 (Yb2). J Biol Chem. 1989 Dec 25;264(36):21582-90
  • Latest
    J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory