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Gsta2 Gene Detail
Summary
  • Symbol
    Gsta2
  • Name
    glutathione S-transferase, alpha 2 (Yc2)
  • Synonyms
    Gst2-2, Gstc-2, Gstc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95863
    NCBI Gene: 14858
  • Member of
    Gsta cluster
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:78238300-78254474 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 43.65 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    864 from dbSNP Build 142
  • Strain Annotations
    10
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95863
 protein coding gene Chr9:78238300-78263070 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0035041
 protein coding gene Chr9:76009953-76020825 (+)
AKR/J MGP_AKRJ_G0034970
 protein coding gene Chr9:77773553-77866523 (+)
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0034715
 protein coding gene Chr9:83619264-83643364 (+)
DBA/2J MGP_DBA2J_G0034877
 protein coding gene Chr9:75732798-75761272 (-)
FVB/NJ MGP_FVBNJ_G0034816
 protein coding gene Chr9:74864900-74935057 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0034858
 protein coding gene Chr9:84813821-84837361 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035578
 protein coding gene Chr9:78061367-78088579 (-)
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0033604
 protein coding gene Chr9:78260090-78293971 (-)
WSB/EiJ MGP_WSBEiJ_G0034177
 protein coding gene Chr9:77888578-77908030 (+)



Homology
more
  • Human Ortholog
    GSTA1, glutathione S-transferase alpha 1
  • Vertebrate Orthologs
    9
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSTA1, glutathione S-transferase alpha 1
  • Synonyms
    GST2, GSTA1-1, GST-epsilon, GTH1
  • Links
    NCBI Gene ID: 2938
    neXtProt AC: NX_P08263
    UniProt: P08263

  • Chr Location
    6p12.2; chr6:52791371-52803860 (-)  GRCh38
  • Human Ortholog
    GSTA2, glutathione S-transferase alpha 2
  • Synonyms
    GST2, GSTA2-2, GTA2, GTH2
  • Links
    NCBI Gene ID: 2939
    neXtProt AC: NX_P09210
    UniProt: P09210

  • Chr Location
    6p12.2; chr6:52750087-52763475 (-)  GRCh38
  • Human Ortholog
    GSTA3, glutathione S-transferase alpha 3
  • Synonyms
    GSTA3-3, GTA3
  • Links
    NCBI Gene ID: 2940
    neXtProt AC: NX_Q16772
    UniProt: Q16772

  • Chr Location
    6p12.2; chr6:52896639-52909698 (-)  GRCh38
  • Human Ortholog
    GSTA5, glutathione S-transferase alpha 5
  • Links
    NCBI Gene ID: 221357
    neXtProt AC: NX_Q7RTV2
    UniProt: Q7RTV2

  • Chr Location
    6p12.2; chr6:52831655-52846245 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human GSTA1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    895
  • Tissues
    95
  • cDNA Data
    29
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 14858 NCBI Gene Model | MGI Sequence Detail 16175 C57BL/6J ±  kb
transcript NM_008182 RefSeq | MGI Sequence Detail 855 ZRU/MplStud  
polypeptide P10648 UniProt | EBI | MGI Sequence Detail 222 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • PDB
    1ML6
  • EC
    2.5.1.18
  • InterPro Domains
    IPR003080 Glutathione S-transferase, alpha class
    IPR004046 Glutathione S-transferase, C-terminal
    IPR036282 Glutathione S-transferase, C-terminal domain superfamily
    IPR010987 Glutathione S-transferase, C-terminal-like
    IPR004045 Glutathione S-transferase, N-terminal
    IPR050213 Glutathione S-transferase superfamily
    IPR040079 Glutathione transferase family
    IPR036249 Thioredoxin-like superfamily
Molecular
Reagents
less
  • All nucleic 31
    cDNA 31

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10309, MGD-MRK-10321, MGD-MRK-10322, MGI:95855
References
more
  • Summaries
    All 44
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 10
  • Earliest
    J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
  • Latest
    J:190322 Archambaud C, et al., Impact of lactobacilli on orally acquired listeriosis. Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16684-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory